Contact allergy to metlpranolol

Allergic Contact Dermatitis Due to ?-blockers in Eye Drops: a Retrospective Analysis of Multicentre Surveillance Data 1993-2004

“…Moreover, allergic reactions to ophthalmic drugs are probably more frequent than described in the literature so far. Diagnostic efforts to identify an alternative agent tolerated by the patient allergic to one P-blocker, led to the observation of delayed-type cross-reactivity between levobunol and carteolol, levobunol and timolol, levobunol and befunolol, befunolol and metipranolol, metipranolol and 1-penbutolol, and befunolol and carteolol in several cases, the development of cross-reactions so far not being predictable (11)(12)(13)(14)(15)(16)(17)(18)(19). Furthermore, it is a question if previous exposure to the "cross-reacting" compound (and concomitant sensitization) was excluded in every case of assumed cross-reaction.…”

Contact allergy to beta‐blocking agents in ophthalmic preparations

“…Contact allergy to topically applied beta-adenergic receptor blocking agents is a recognized but infrequently reported side-effect of glaucoma treatment. Sensitization may involve a single agent, e.g., timolol (4-6), befunolol (7,8), metipranolol (8), and levobunolol (9), or to > 1 beta blocker in a single patient (10,11). The 3 patients of Van Joost et al (10), allergic to metoprolol, each reacted to 1 other beta-blocker (propranolol, practolol, timolol).…”

Contact dermatitis to topical drugs for glaucoma

“…11,28,29 Using a standard series of test solutions, Lernia et al 23 showed positive patch test reactions to levobunolol in 1 patient that had negative reactions in 5 test subjects. This was similarly observed by Sanchez-Perez et al, 27 with 1 patient with a positive patch test reaction to carteolol, of which the test solutions were negative in 23 control patients.…”