Contact allergy to spearmint oil in a patient with oral lichen planus

Clayton, Rima; Orton, David

doi:10.1111/j.0105-1873.2004.0459f.x

Cited by 22 publications

(13 citation statements)

References 4 publications

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“…Carvone is considered a weak sensitizer (6) and the prevalence of contact allergy in patch-tested cohorts has been estimated to be 1.6-2.8% (7,8). A few papers on patients' adverse reactions to carvone or spearmint oil have reported both perioral and intraoral lesions from oral healthcare products, with intraoral lesions described as stomatitis or erosions associated with oral lichen planus (OLP) (9)(10)(11)(12)(13). Studies on patients with OLP or oral lichenoid lesions (OLL) have shown an association with carvone or spearmint contact allergy (14)(15)(16).…”

mentioning

confidence: 99%

Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Kroona¹,

Isaksson²,

Ahlgren³

et al. 2018

Acta Derm Venerol

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Carvone (l-carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen planus, but studies are sparse. The prevalence of patch test reactions to carvone and relevant findings from the positive group were investigated. Records for patch-tested patients at the Malmö clinic, for the period 1996 to 2016, were studied. Carvone-positive and carvone-negative patients were compared regarding patch test data from baseline series and dental series. Dental series-tested carvone-positive patients were also compared with a matched group. A total of 147 out of 4,221 referred patients had a positive patch test to carvone. Sensitized patients had higher mean age and were primarily women; 73% had oral signs and 57% had oral lichen. Concomitant patch test reactions to gold, nickel and mercury were common. In the matched group-comparison carvone-positive patients had a higher frequency of oral lichen, but no difference was found in sensitization to gold and mercury.

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mentioning

confidence: 99%

Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Kroona¹,

Isaksson²,

Ahlgren³

et al. 2018

Acta Derm Venerol

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“…Exposure to derivatives of cinnamon acid contained in toothpaste, chewing gum and sweets leads to lichenoid changes on the buccal mucosa and tongue 11 . Menthol and peppermint found in oral hygiene products, as well as in teas, liquors, gum, etc may induce intraoral erosions and lichenoid changes 31 . Eugenol from clove oil, popular in stomatology for its disinfecting and aromatizing qualities may have a similar effect on the mucosa 32 .…”

mentioning

confidence: 99%

Oral Lichenoid Lesions and Allergy to Dental Materials

Ditrichová¹,

Kaprálová²,

Tichý³

et al. 2007

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background: Dental materials, oral hygiene products and food additives may cause contact allergic reactions in the mouth with varied clinical presentation. Oral lichenoid lesions (lichen planus-like lesions) can be induced by hypersensitivity to dental restorative metals, acrylates, fl avorings and other substances.Aim: The aim of this study was to demonstrate contact allergy to dental materials in patients with oral lichenoid lesions using patch tests.Patients and methods: Routine patch tests with two sets of allergens -"European Standard" and "Dental Screening" (Chemotechnique Diagnostics, Sweden) supplemented with pulverized amalgam, iridium, indium, menthol, sorbic acid and platinum were done on a set of 25 patients with lichenoid lesions located on the buccal mucosa, tongue and lips. Application and interpretation of the tests were conducted according to ICDRG (International Contact Dermatitis Research Group).Results: 15 (60 %) patients showed sensitization to 1 or more allergens, with a total of 31 positive reactions. The greatest frequency of positive reactions was to dental metals, with a total of 27 positive reactions. The order of tested metals according to frequency of positive reactions was mercury (6/25/24 %), amalgam (6/25/24 %), nickel (4/25/16 %), palladium (4/25/16 %), cobalt (3/25/12 %), gold (2/25/8 %), chrome (1/25/4 %), indium (1/25/4 %). The clinical relevance of the results with regard to the material's presence in the mouth was demonstrated in 11 (44 %) patients. In 9 patients, replacement of the positively tested materials led to healing or to signifi cant regression of mucosal changes. Conclusions:The results of the patch tests showed the possible contribution of contact sensitization in the pathogenesis of lichenoid manifestations in the oral cavity. Due to the premalignant character of these lesions, replacement of positively tested materials and follow up of these patients is advised.

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“…The oral and perioral allergic reactions seen in paper III were similar to those reported in the literature (1,6,7,(73)(74)(75)(76)(77)(78)(79). Contact cheilitis and perioral contact dermatitis developed where there were no previous lesions.…”

Section: Defining Oral Contact Allergy To Carvonesupporting

confidence: 86%

“…cheilitis or perioral dermatitis. Oral findings were diffusely described as 'oral involvement' or 'oral erosions in a patient with OLP' (1,(74)(75)(76)(77)(78)(79). Ahlgren et al found that patients with oral lichen had a higher frequency of l-carvone sensitisation compared to dermatitis patients, 12.1 % versus 1.2% (6).…”

Section: Contact Allergy To Carvonementioning

confidence: 99%

Oral contact allergy to carvone : with a focus on oral lichen

Kroona¹

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This thesis examines carvone (l-carvone), a mint flavour, and contact allergy to carvone with a focus on oral lichen. Carvone is a constituent of spearmint oil and is used to flavour toothpaste and food. Like many flavours and fragrances, carvone may cause contact allergy, but the prevalence is low, between 1.6 and 2.8%. Affected patients often have perioral or oral signs. A couple of studies have shown that patients with oral lichen planus or oral lichenoid lesions often have contact allergy to carvone but it is not known if these lichenoid lesions are a manifestation of contact allergy or part of the auto-immune disease, oral lichen planus. In paper I, the amount of carvone was measured in 66 toothpastes and the ingredient lists were studied. Carvone was detected in all toothpastes with flavour, even fruit flavoured toothpaste, in up to 0.35%. The measured concentrations were all within the safe use level estimated to not induce contact allergy, but carvone concentrations over 0.1% are high enough to elicit a reaction in already allergic individuals. The regulation of carvone as a constituent in toothpaste was discussed. Registry data (age, sex, referring information and patch tests results) on patients with a positive patch test reaction to carvone was studied in paper II. Data was retrieved from 1996 to 2016 and was compared with other patch tested groups not allergic to carvone. A matched comparison was also made between carvone-positive and carvone-negative patients tested with the same test series. Patients with contact allergy to carvone had a high mean age and were often women. According to the referrals, they often had oral signs and

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Contact allergy to spearmint oil in a patient with oral lichen planus

Cited by 22 publications

References 4 publications

Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study

Oral Lichenoid Lesions and Allergy to Dental Materials

Oral contact allergy to carvone : with a focus on oral lichen

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