Contact Allergy to Topical Drugs

Goossens, An; Gonçalo, Margarida

doi:10.1007/978-3-030-36335-2_38

Cited by 2 publications

(4 citation statements)

References 247 publications

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“…9 Multiple authors have published on the most common allergens responsible for ACD in patients with VLU, with variations in rates of sensitization based in part on local prescribing patterns. 30,31 The most common by far is fragrance; however, adhesives, rubber allergens, lanolin, topical antimicrobials, anesthetics, and topical corticosteroids, are close contenders. 2,[32][33][34][35] Fragrances are well-known sensitizers, and because they are often a hidden component of skin cleansers, wound-dressing products, moisturizers, and topical antimicrobials, it is not surprising that they top the list.…”

Section: Diagnosing Acdmentioning

confidence: 99%

“…37 Although most of these haptens can be tested using regional standard series, it is always prudent to test using the patient's own products whenever possible. 31 There are some restrictions to PT. The testing field requires a large expanse of normal skin that is free of eczema and tattoos.…”

Section: Diagnosing Acdmentioning

confidence: 99%

“…Multiple authors have published on the most common allergens responsible for ACD in patients with VLU, with variations in rates of sensitization based in part on local prescribing patterns 30,31 . The most common by far is fragrance; however, adhesives, rubber allergens, lanolin, topical antimicrobials, anesthetics, and topical corticosteroids, are close contenders 2,32-35 .…”

Section: Diagnosing Acdmentioning

confidence: 99%

“…Self-adhering dressings need adhesives, and colophony and acrylates are the most likely to cause ACD 37 . Although most of these haptens can be tested using regional standard series, it is always prudent to test using the patient’s own products whenever possible 31 …”

Section: Diagnosing Acdmentioning

confidence: 99%

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What Is the Role of Allergic Contact Dermatitis in Patients with Lower Leg Ulcers?

Parsons

2023

Adv Skin Wound Care

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Lower leg ulcers are a common clinical presentation to wound care clinics. They are often associated with the presence of dermatitis on the periwound skin, which can be a factor in delayed wound healing. Correctly diagnosing the underlying etiology is critical to reversing the breakdown in the skin barrier function. The author discusses allergic contact dermatitis as an etiology and describes the most common allergens, fragrances, and preservatives identified from a limited literature review. Patch testing is the criterion standard for the diagnosis of allergic contact dermatitis and is the most appropriate means of identifying causative allergens. An algorithm for the identification and treatment of lower leg dermatitis is provided to simplify the process. GENERAL PURPOSE To analyze the relationship between contact dermatitis and delayed wound healing, discuss the diagnosis and treatment of lower leg contact dermatitis, and provide an algorithm for the patient with a red leg and delayed wound healing. TARGET AUDIENCE This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES After participating in this educational activity, the participant will: 1. Describe the nature of contact dermatitis. 2. Distinguish between allergic and irritant contact dermatitis and the other major differential diagnoses of delayed wound healing in this clinical scenario. 3. Outline the steps in the diagnosis of allergic contact dermatitis and irritant contact dermatitis and identify common haptens responsible for allergic contact dermatitis in patients with venous leg ulcers. 4. Apply the algorithm for delayed wound healing on a background of lower leg dermatitis.

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Section: Diagnosing Acdmentioning

confidence: 99%

Section: Diagnosing Acdmentioning

confidence: 99%

Section: Diagnosing Acdmentioning

confidence: 99%

Section: Diagnosing Acdmentioning

confidence: 99%

See 2 more Smart Citations

What Is the Role of Allergic Contact Dermatitis in Patients with Lower Leg Ulcers?

Parsons

2023

Adv Skin Wound Care

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Allergic Contact Dermatitis

Orton,

Stone

2024

Rook's Textbook of Dermatology

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Allergic contact dermatitis is considered to be a prototype of delayed hypersensitivity reactions requiring two phases – induction and elicitation. The amount of allergen per skin surface area is the key factor that determines the risk of induction. Exposure‐related factors that influence the elicitation phase include allergen concentration (dose), duration and frequency of exposure, the matrix, the presence of irritants and the region of application. A diagnosis of allergic contact dermatitis requires careful evaluation of a patient's clinical history when the suspicion is aroused, physical examination, and various types of skin testing (patch testing, photopatch testing and repeat open application tests. During the last few decades much effort has been put into standardisation of allergens, vehicles, test concentrations and the scoring of test reactions. This chapter provides information on the diagnosis and management of allergic contact dermatitis and information on the major allergens involved in regional dermatitis.

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Contact Allergy to Topical Drugs

Cited by 2 publications

References 247 publications

What Is the Role of Allergic Contact Dermatitis in Patients with Lower Leg Ulcers?

What Is the Role of Allergic Contact Dermatitis in Patients with Lower Leg Ulcers?

Allergic Contact Dermatitis

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