Contact Behavior of Microcrystalline Cellulose Pellets Depending on their Water Content

Grohn, Philipp; Weis, Dominik; Thommes, Markus; Heinrich, Stefan; Antonyuk, Sergiy

doi:10.1002/ceat.201900517

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…In contrast, the result of the simulation was affected strongly by the coefficient of restitution. An increase in e caused a higher degree of interaction between the particles, which is in accordance with experimentally determined literature data 33, 34.…”

Section: Methodssupporting

confidence: 92%

Simulation of Powder Flow Behavior in an Artificial Feed Frame Using an Euler‐Euler Model

et al. 2022

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The Eulerian approach is an alternative numerical method to the traditionally used discreet particle techniques for modeling powder flow, avoiding limitations on particle number and diameter. The feasibility of an Euler-Euler simulation in a pharmaceutical application was investigated. In two-and three-dimensional flow simulations, computational fluid dynamics models and parameters were determined and verified based on comparison with experiments. Residence time distributions were calculated to show the applicability of the Eulerian model with two granular phases under the constraint of a continuous setup. Finally, this model was implemented to improve the process understanding of the powder flow in an artificial feed frame of a rotary tablet press.

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Section: Methodssupporting

confidence: 92%

Simulation of Powder Flow Behavior in an Artificial Feed Frame Using an Euler‐Euler Model

et al. 2022

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“…Material attributes include, for example, knowledge of the mechanical properties of the pellets [41] or surface roughness, which may also affect the quality of the polymer coating.…”

Section: Layering and Coating Processes Of Inert Coresmentioning

confidence: 99%

Review on Starter Pellets: Inert and Functional Cores

et al. 2022

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A significant proportion of pharmaceuticals are now considered multiparticulate systems. Modified-release drug delivery formulations can be designed with engineering precision, and patient-centric dosing can be accomplished relatively easily using multi-unit systems. In many cases, Multiple-Unit Pellet Systems (MUPS) are formulated on the basis of a neutral excipient core which may carry the layered drug surrounded also by functional coating. In the present summary, commonly used starter pellets are presented. The manuscript describes the main properties of the various nuclei related to their micro- and macrostructure. In the case of layered pellets formed based on different inert pellet cores, the drug release mechanism can be expected in detail. Finally, the authors would like to prove the industrial significance of inert cores by presenting some of the commercially available formulations.

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“…The particle properties needed for the DEM simulations were obtained by several experimental setups. The coefficient of the restitution was measured with a free-fall device, as described in the work of Grohn et al [2]. The Young's modulus was determined with a Nanoindenter (Hysitron TI Premier, Bruker Corporation, Billerica, MA, USA), and the friction coefficients with a Texture Analyser ® (TA.XTplus, Stable Micro Systems, London, UK).…”

Section: Simulation Parametersmentioning

confidence: 99%

“…While agglomeration is encouraged in some processes, it should be avoided in others. Especially in the pharmaceutical industry, round, coated pellets are needed for oral drug delivery [2]. The fluidized bed rotor granulator was developed in order to be able to carry out the individual process steps of spheronization, coating, and drying in one apparatus.…”

Section: Introductionmentioning

confidence: 99%

CFD-DEM Simulation of a Coating Process in a Fluidized Bed Rotor Granulator

et al. 2020

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Coating of particles is a widely used technique in order to obtain the desired surface modification of the final product, e.g., specific color or taste. Especially in the pharmaceutical industry, rotor granulators are used to produce round, coated pellets. In this work, the coating process in a rotor granulator is investigated numerically using computational fluid dynamics (CFD) coupled with the discrete element method (DEM). The droplets are generated as a second particulate phase in DEM. A liquid bridge model is implemented in the DEM model to take the capillary and viscous forces during the wet contact of the particles into account. A coating model is developed, where the drying of the liquid layer on the particles, as well as the particle growth, is considered. The simulation results of the dry process compared to the simulations with liquid injection show an important influence of the liquid on the particle dynamics. The formation of liquid bridges and the viscous forces in the liquid layer lead to an increase of the average particle velocity and contact time. Changing the injection rate of water has an influence on the contact duration but no significant effect on the particle dynamics. In contrast, the aqueous binder solution has an important influence on the particle movement.

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Contact Behavior of Microcrystalline Cellulose Pellets Depending on their Water Content

Cited by 10 publications

References 24 publications

Simulation of Powder Flow Behavior in an Artificial Feed Frame Using an Euler‐Euler Model

Simulation of Powder Flow Behavior in an Artificial Feed Frame Using an Euler‐Euler Model

Review on Starter Pellets: Inert and Functional Cores

CFD-DEM Simulation of a Coating Process in a Fluidized Bed Rotor Granulator

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