Contact Dermatitis From Neomycin and Framycetin

Kirton, V.

doi:10.1016/s0140-6736(65)91094-9

Cited by 39 publications

(10 citation statements)

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“…21 We have known about very high framycetin sensitisation in leg ulcer patients for decade. 22,23 A number of antibiotic-and antiseptic-impregnated dressings are also used in ulcer management. 24 Eosin sensitisation has been reported in 2 studies.…”

Section: Discussionmentioning

confidence: 99%

“…In spite of lack of evidences of the efficacy of framycetin or other antibiotics, the practice of topical antibiotic usage widely prevails in wound care . We have known about very high framycetin sensitisation in leg ulcer patients for decade . A number of antibiotic‐ and antiseptic‐impregnated dressings are also used in ulcer management .…”

Section: Discussionmentioning

confidence: 99%

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Contact sensitivity in patients with venous leg ulcer: A multi‐centric Indian study

Rai

Shenoy

Viswanath

et al. 2018

International Wound Journal

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Venous leg ulcers are the most common form of non-healing leg ulcers. They are subjected to treatments such as topical medications, dressings, and compression therapies. This can lead to exposure to a number of allergens with subsequent sensitisation and contact dermatitis of the regional skin. This may contribute to the poor ulcer healing. To detect the various contact sensitisers in patients with venous leg ulcers through patch testing, patients from 6 centres across India with venous leg ulcers of longer than 6 weeks duration were enrolled for the study. They were patch tested using a special parch test kit with 27 antigens. A total of 172 patients were included in the study; 82 (48.2%) tested positive for at least 1 antigen. Among them, polyvalent sensitisation was noted in 71% of patients. Wood tar mix (10.4%) and the framycetin (8.7%) were the most common allergens. There is a high frequency of allergic sensitisation to various ingredients of topical therapies used in the venous ulcer management, which may interfere with wound healing. Avoiding them can help obtain a better therapeutic outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Contact sensitivity in patients with venous leg ulcer: A multi‐centric Indian study

Rai

Shenoy

Viswanath

et al. 2018

International Wound Journal

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“…Contact allergy to the aminoglycosides in chronic inflammatory ear disease has been well reported throughout the last 3 decades, with most authors recommending avoidance of routine or prolonged use in such conditions. Kirton and Munro‐Ashman (5) and Jensen et al (6) brought the problem to the attention of general physicians. The overall percentages of patients with allergic patch test reactions in our series to neomycin (21%), framycetin (16%) and gentamicin (8%) are similar to the mean figures from previous studies (Table 5), emphasizing that the trends are found within our sample, not by comparing it to other samples in other countries.…”

Section: Discussionmentioning

confidence: 99%

Changing patterns of contact allergy in chronic inflammatory ear disease

Millard

Orton

2004

Contact Dermatitis

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Chronic inflammatory ear disease comprises a wide range of conditions. Although contact allergy to topical medicaments is common in such conditions, the causes of these reactions have not been examined in a large series for over a decade. Our aim was to investigate the major sensitizers recorded in 179 patients over the last 17 years. Medicament contact allergic dermatitis was diagnosed in 45 patients (25%), of whom 34 (76%) demonstrated a relevant allergy to neomycin, 28 (62%) to framycetin, 11 (31%) to gentamicin, 8 (18%) to quinoline mix and 5 (11%) to caine mix. Of all neomycin-allergic patients, 28 (76%) were also allergic to framycetin and 12 (43%) to gentamicin. Comparing the first 60 patients (1985-94) to the most recent 60 (1998-2002) identified a significant recent reduction in the number of patients allergic to neomycin (P = 0.002) and framycetin (P = 0.050), with a non-significant reduction in the total number diagnosed as medicament-allergic (P = 0.066). We have therefore demonstrated a high frequency of medicament contact allergy in chronic inflammatory ear disease, supporting the routine use of patch testing in these patients. We have also shown a significant recent reduction in the number of such patients with allergy to neomycin and framycetin.

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“…The allergic sensitivity to neomycin may not be readily suspected since neomycin dermatitis is slow to develop, slow to spread and often is dry and scaly, rather than eczematous and oozing. The onset is insidious and it runs a very protracted course (Epstein, 1966 ;Kirton et al, 1965).…”

Section: Antibiotic Agentsmentioning

confidence: 99%