Contact dermatitis from tioconazole with cross‐sensitivity to other imidazoles

Fixed‐drug eruption due to metronidazole with positive topical provocation

“…In our patient, topical provocation was positive to metronidazole, but despite its pharmacological similarity, tinidazole was negative on topical provocation. Izu et al (4) described cross‐reactivity between metronidazole (a nitroimidazole) and tioconazole (a phenethyl imidazole), in a patient with contact dermatitis due to tioconazole. In our patient, topical provocation with tioconazole was negative.…”

Allergic contact dermatitis to topical antibiotics: Epidemiology, responsible allergens, and management

“…The authors recommended that patients with contact allergy to any imidazole should be patch tested with other imidazoles because of the possibility of cross-reactivity. 150 Mupirocin. Mupirocin is produced by fermentation of the organism Pseudomonas fluorescens and inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl t-RNA synthetase.…”

Is tioconazole contact dermatitis still a concern? Bringing allergic contact dermatitis caused by topical tioconazole back into the spotlight

“…Publications on allergic contact dermatitis caused by tioconazole became common following its introduction, in the years 1989 to 1996, and many were related to exposure to a medicated nail solution (Table S2). Interestingly, to our knowledge, no cases have been reported since then in the English‐language literature.…”