Contact Dermatitis Reaction to 2-Octyl Cyanoacrylate Following 3 Orthopedic Procedures

Abstract

Two-octyl cyanoacrylate is a popular skin adhesive used for closing surgical incisions. Since Food and Drug Administration approval in 1998, the few reports of adverse reactions following its use have primarily been limited to the nonorthopedic literature. The authors present a case series of contact dermatitis associated with 2-octyl cyanoacrylate following orthopedic surgery and a review of the literature on the diagnosis and treatment of this complication. All 3 patients presented with blistering around their incisions within 2 weeks of surgery and responded to treatment involving removal of the offending agent and use of oral diphenhydramine and hydroxyzine and topical triamcinolone. One case was complicated by a draining hematoma, requiring irrigation and debridement. Complete resolution occurred in all cases. This case series is intended to increase awareness in the orthopedic community of allergic contact dermatitis to 2-octyl cyanoacrylate and its appropriate treatment. [Orthopedics. 2018; 41(2):e289-e291.].

Cyanoacrylate closure for peripheral veins: Consensus document of the Australasian College of Phlebology

“…Reported complication of CAC in its use as an adhesive for wound closure has been limited to contact dermatitis and allergic reactions. 81,82 Treatment protocols…”

Comparison of 2-octyl cyanoacrylate skin adhesive and interrupted polypropylene sutures for wound closure in total ankle arthroplasty

“…These can lead to ACD or wound dehiscence and can cause critical complications such as deep SSI [ 10 , 25 , 27 – 29 , 34 – 37 , 39 – 42 ]. ACD is more likely to develop when the skin is in prolonged contact with the allergen or when the amount of allergen is high [ 36 , 37 , 39 ].…”

Granuloma formation following cyanoacrylate glue injection in peripheral veins and arteriovenous malformation

“…An immune response to n-BCA is not surprising as there are multiple case reports of delayed-type hypersensitivity reactions and in particular, contact dermatitis to CA. [11][12][13][14][15][16][17][18][19][20][21][22] A recent case report described contact dermatitis to Venaseal TM glue, another n-BCA used to treat peripheral veins. 23 Our histological findings are consistent with the published literature demonstrating foreign body granuloma formation as a late tissue reaction to n-BCA.…”