Contact Dermatitis Sparing the Eruption of Herpes zoster and Its Periphery

Katayama, Hiroshi; Karube, Sachiko; Ueki, Yoko; Yaoita, Hideo

doi:10.1159/000247866

Cited by 16 publications

(17 citation statements)

References 10 publications

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“…For example, some of the numerous reports of zosteriform metastases published in the literature 61-63 might well be typical cases of Wolf's post-herpetic response subsequent to asymptomatic shingles (so-called 'zoster sine herpete', from Latin, meaning zoster without herpes). 58 Alongside the cases of post-herpetic isotopic response, there are also reports of widespread skin disorders (contact dermatitis, 64 cutaneous T-cell lymphoma, 65,66 Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) 66 ) which spared precisely the cutaneous areas that had been the herpes zoster site. These interesting observations, apparently the opposite of Köbner phenomenon (Renbök phenomenon) [34][35][36] and of the isotopic response (thus named isotopic nonresponse by Wolf et al 38 ), show that cutaneous areas previously affected by herpes zoster but healed behave in an unpredictable manner with the passing of time.…”

Section: Herpes-infected Sites (Wolf's Isotopic Response)mentioning

confidence: 99%

The immunocompromised district: a unifying concept for lymphoedematous, herpes‐infected and otherwise damaged sites

Ruocco¹,

Brunetti

Puca

et al. 2009

Acad Dermatol Venereol

206

275

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Systemic immunodeficiency is known to facilitate the onset of opportunistic infections, tumours and immune disorders in any district of the body. There are clinical events, such as chronic lymphoedema, herpetic infections, vaccinations and heterogeneous physical injuries which can selectively damage and immunologically mark the cutaneous district they act upon. After the causing event has disappeared, the affected district may appear clinically normal, but its immune behaviour is often compromised forever. An immunocompromised district becomes a site which is particularly susceptible to subsequent outbreaks of opportunistic infections, tumours and immune disorders confined to the district itself. In this review, there is an ample case-report collection of opportunistic disorders (infectious, neoplastic, immune) which appeared in immunocompromised districts. The cases have been grouped according to the clinical settings responsible for the local immune imbalance: regional chronic lymphoedema; herpes-infected sites, which feature the well-known Wolf's isotopic response; and otherwise damaged areas, comprising sites of vaccination, ionizing or UV radiation, thermal burns and traumas. Whatever the immunocompromising factor, a common denominator which facilitates the occurrence of tumours, infections and dysimmune reactions in an immunocompromised district may reside in locally hampered lymph drainage and/or locally altered neuromediator signalling. In fact, any obstacle to the normal trafficking of immunocompetent cells through lymphatic channels or any interference with the signals that the neuropeptides and neurotransmitters released by peripheral nerves send to cell membrane receptors of immunocompetent cells, can significantly alter the local immune response, thus paving the way for heterogeneous opportunistic disorders in the immunocompromised district.

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Section: Herpes-infected Sites (Wolf's Isotopic Response)mentioning

confidence: 99%

The immunocompromised district: a unifying concept for lymphoedematous, herpes‐infected and otherwise damaged sites

Ruocco¹,

Brunetti

Puca

et al. 2009

Acad Dermatol Venereol

206

275

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“…There has been one report of contact dermatitis sparing the eruption of herpes zoster and its periphery. 13 These authors speculated that a decrease in LC activity in the herpes zoster lesions and their peripheral area was responsible for the observed phenomenon, but no analysis of LC presence or activity was performed. A reduced number or absence of epidermal LC has been demonstrated in several viral lesions, including those caused by the Herpesvirus herpes simplex virus.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous T-cell lymphoma sparing resolving dermatomal herpes zoster lesions: an unusual phenomenon and implications for pathophysiology

Twersky

Nordlund

2004

Journal of the American Academy of Dermatology

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“…Ampicillin and clotrimaxazole-trimethopim were the most noted culprits [2,3,9]. An area subjected to herpes zoster was the often resistant site for the many diseases including leprosy and CTCL [10][11][12][13]. Psoriasis sparing an area of alopecia areata and previously irradiated site was found in three occasions and non occurrence of drug reaction and CTCL in an area exposed to ultra violet light (swimming suit sparing) were documented in two instances [3][4][5]14,15].…”

Section: Literature Review and Summarymentioning

confidence: 99%

“…Irradiation has been reported to induce loss of Langerhans cell and other immunological changes in the subjected skin [18]. Reduction of Langerhans cell number and it's activity in herpes zoster lesion and their peripheral area has recently been documented by Katayama et al and Nikkles et al [10,12,13]. This abnormality in Langerhans cell number could influenced drug reaction, allergic contact dermatitis and CTCL didn't occur in the area affected by irradiation and herpes zoster.…”

Section: Cellular Alterationsmentioning

confidence: 99%

The Sparing Phenomenon. A case series of the inverse Koebner and related phenomena

Kannangara¹,

Fleischer²,

Yosipovitch³

2013

Our Dermatol Online

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Introduction:The sparing of the involvement of a cutaneous disease in a site that has been previously subjected to a skin disease, congenital nevus or physical insult has been reported in literature by various names, including the inverse Koebner phenomenon. Objectives: To review cases that we have seen and to document the reported cases and unify them with a single term, the "Sparing phenomenon". Materials and Methods:We report four new examples of this phenomenon and performed a PubMed literature search on related search terms and summarized the reported cases. Results: We report four new cases of this phenomenon. An additional 16 reported cases of the sparing phenomenon were identified. Herpes zoster was the most reported inflammatory disease site followed by; skin irradiation was the commonly documented physical insult. Drug reactions and psoriasis were the most common diseases that spare these sites. The time gap between first and second insult was highly variable. Conclusions: We proposed the term "Sparing phenomenon" to describe the skin disease sparing on an area which was previously subjected to skin disease or physical insult. By introducing this new term to the dermatology glossary, it would be easy to collect and analysis to understand the immuno-pathophsiology of this skin reaction described in various names.

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Contact Dermatitis Sparing the Eruption of Herpes zoster and Its Periphery

Cited by 16 publications

References 10 publications

The immunocompromised district: a unifying concept for lymphoedematous, herpes‐infected and otherwise damaged sites

The immunocompromised district: a unifying concept for lymphoedematous, herpes‐infected and otherwise damaged sites

Cutaneous T-cell lymphoma sparing resolving dermatomal herpes zoster lesions: an unusual phenomenon and implications for pathophysiology

The Sparing Phenomenon. A case series of the inverse Koebner and related phenomena

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