Contact dermatitis to parthenium weed treated with methotrexate and triamcinolone acetonide

Abstract

The authors present a case of contact dermatitis due to contact with parthenium weed (CDP) treated with intralesional injection of triamcinolone acetonide and methtotrexate 7.5 mg/week for 4 weeks. Discussion about CDP is mentioned in short.

Methotrexate use in allergic contact dermatitis: a retrospective study

“…Fifty per cent of the improvement in the methotrexate group was seen in the first month, and there was a sustained decrease in the dermatitis score with continuation for 6 months . Another study showed that methotrexate, both alone and in combination with a topical corticosteroid, is a useful option in severe P. hysterophorus dermatitis that is unresponsive to conventional treatment (, ). Methotrexate has also shown better efficacy than azathioprine in the treatment of atopic dermatitis in multiple studies (, ).…”

“…A variety of medications for use in the treatment of allergic contact dermatitis have been reported in controlled trials, case series, and reviews (2)(3)(4)(5)(6)(7)(8). These medications fall under the categories of corticosteroids, non-steroidal drugs, immunomodulators, barrier creams, and emollients.…”

“…showed that methotrexate is as efficacious as azathioprine in the treatment of Parthenium hysterophorus allergic contact dermatitis, but with a shorter treatment time . Additionally, methotrexate may be useful in treating severe P. hysterophorus dermatitis that is unresponsive to conventional treatment (, ).…”