A driveshaft is a small spring coil less than 1mm in diameter, composed of several stainless-steel wire filaments. In intervention, the driveshaft is used to transmit force and motion to the inside body through the existing micro channels (such as arteries, veins, and gastrointestinal tract). The performance of the driveshaft determines the efficiency, stability, and accuracy of force and motion transitions, the ability to pass through tortuous microchannels, and the damage to healthy tissues. To determine the influence of fabrication parameters (filament, wire diameter, and outer diameter) on the mechanical properties (such as bending stiffness and natural frequency) of the driveshaft, a simulation was established in ABAQUS to calculate the deformation displacement under 0.0098N and first-order natural frequency. Then, the bending stiffness is calculated. The results show that the bending stiffness and the first-order natural frequency of the driveshaft increase with the increase of the filament number and wire diameter, and with the outer diameter of the driveshaft increases, the bending stiffness increases, while the first-order natural frequency decreases. Finally, the simulation model is verified by measuring the deformation displacement in the experiment. This study provides a methodology for designing and selecting the driveshaft in Interventional therapy.