Contact Lens Safety for the Correction of Refractive Error in Healthy Eyes

Rhee, Michelle K.; Jacobs, Deborah S.; Dhaliwal, Deepinder K.; Szczotka-Flynn, Loretta; Prescott, Christina; Jhanji, Vishal; Steinemann, Thomas L.; Koffler, Bruce H.; Jeng, Bennie H.

doi:10.1097/icl.0000000000000938

Cited by 12 publications

(5 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 Reports of infection risks associated with unregulated and unsupervised decorative lenses galvanized ophthalmic societies (American Academy of Ophthalmology, American Academy of Optometry, and Contact Lens Association of Ophthalmologists) led by Thomas L. Steinemann, MD, to work with the FDA to create an amendment to the Federal Food, Drug, and Cosmetic Act to include decorative plano lenses as an FDA-regulated medical device. 2…”

Section: Contact Lenses and Decorative Contact Lensesmentioning

confidence: 99%

Unregulated Decorative Lenses: A Brief Definitive Review

Han,

Rhee

2024

Cornea

Self Cite

View full text Add to dashboard Cite

Contact lenses are US Food and Drug Administration-regulated medical devices that are a safe and effective method for the correction of refractive error. They are worn by an estimated 45 million Americans. Decorative contact lenses (DCLs) can be used for patients with medical conditions such as failed corneas or aniridia. However, DCLs have also gained popularity in the young, contact lens-naïve population. DCL users often buy lenses through unregulated sources without a clinical examination and education on proper use by an eye care professional. These lenses have a significantly higher risk of infection when compared with contact lenses for the correction of refractive error. To reduce the incidence of microbial keratitis, regulators and eye care professionals must make coordinated efforts to generate and disseminate prevention messages to all contact lens users. In addition, physician and patient reporting of contact lens-related complications to regulatory agencies enhances the pathway to risk reduction. This article reviews DCL use and supply, with a specific focus on the increased risk of contact lens-related complications in unsupervised DCL use.

show abstract

Section: Contact Lenses and Decorative Contact Lensesmentioning

confidence: 99%

Unregulated Decorative Lenses: A Brief Definitive Review

Han,

Rhee

2024

Cornea

Self Cite

View full text Add to dashboard Cite

show abstract

“…They are constantly exposed to several risk factors, including allergens, debris, pathogens, desiccation, cosmetics, injury, and rubbing [1]. Recently, in the eye care field, the use of contact lenses (CLs) has become a safe, effective, and preferred method for correcting refractive errors or for cosmetic purposes [2]. In addition, CL wear also significantly enhances the risk of ocular complications like microbial keratitis, CL-related peripheral ulcer, cornea-conjunctival neovascularization, superior limbic keratoconjunctivitis, dry eye, and CL discomfort [3,4].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Nilavembu Choornam–Gold Nanoparticles on Antibiotic-Resistant Bacterial Susceptibility and Contact Lens Contamination-Associated Infectious Pathogenicity

Almutleb,

Ramachandran,

Khan

et al. 2024

IJMS

View full text Add to dashboard Cite

Antibiotic-resistant bacterial colonies mitigate rapid biofilm formation and have complex cell wall fabrications, making it challenging to penetrate drugs across their biofilm barriers. The objective of this study was to investigate the antibacterial susceptibility of antibiotic-resistant bacteria and contact lens barrenness. Nilavembu Choornam–Gold Nanoparticles (NC–GNPs) were synthesized using NC polyherbal extract and characterized by UV-visible spectrophotometer, SEM-EDX, XRD, Zeta sizer, FTIR, and TEM analysis. Contact lenses with overnight cultures of antibiotic-resistant bacteria K. pneumoniae and S. aureus showed significant differences in growth, biofilm formation, and infection pathogenicity. The NC–GNPs were observed in terms of size (average size is 57.6 nm) and surface chemistry. A zone of inhibition was calculated for K. pneumoniae 18.8 ± 1.06, S. aureus 23.6 ± 1.15, P. aeruginosa 24.16 ± 0.87, and E. faecalis 24.5 ± 1.54 mm at 24 h of NC–GNPs alone treatment. In electron microscopy studies, NC–GNP-treated groups showed nuclear shrinkage, nuclear disintegration, degeneration of cell walls, and inhibited chromosomal division. In contrast, normal bacterial colonies had a higher number of cell divisions and routinely migrated toward cell multiplications. NC–GNPs exhibited antibacterial efficacy against antibiotic-resistant bacteria when compared to NC extract alone. We suggest that NC–GNPs are highly valuable to the population of hospitalized patients and other people to reduce the primary complications of contact lens contamination-oriented microbial infection and the therapeutic efficiency of antibiotic-resistant bacterial pathogenicity.

show abstract

“…Contact lenses are worn by over 150 million people worldwide to correct their refractive impairments [1]. Yet, extensive use of these lenses provides a wide range of complications, from superficial punctate keratitis to potentially blinding infectious keratitis [2]. The major cause of infectious keratitis is poor hygiene and contaminated contact lens cases [3].…”

Section: Introductionmentioning

confidence: 99%

Multi-Target Effect of Aloeresin-A against Bacterial and Host Inflammatory Targets Benefits Contact Lens-Related Keratitis: A Multi-Omics and Quantum Chemical Investigation

Roshni,

Ahmad,

Wani

et al. 2023

Molecules

View full text Add to dashboard Cite

Contact lens-mediated microbial keratitis caused by Pseudomonas aeruginosa and Streptococcus pneumoniae provokes corneal damage and vision loss. Recently, natural phytochemicals have become complementary medicines for corneal destruction. Herein, we aimed to identify multi-targeting Aloe vera-derived phytochemicals capable of inhibiting bacterial and host targets of keratitis through ADME (absorption, distribution, metabolism, and excretion), docking, molecular dynamics (MD) simulation, MMGBSA (molecular mechanics generalized Born surface area) and density functional theory (DFT) investigations. An extensive literature search revealed ExoU, ExoS, ExoT, ExoY, and PLY as virulent bacterial targets. Simultaneously, differential gene expression (DGE) and pathway enrichment analysis-specified host transcription factor (SPI1) influences keratitis pathogenesis. Molecular docking analysis uncovered aloeresin-A as a promising inhibitor against bacterial and host targets, demonstrating strong binding energies ranging from −7.59 to −6.20 kcal/mol. Further, MMGBSA and MD simulation analysis reflect higher binding free energies and stable interactions of aloeresin-A with the targets. In addition, DFT studies reveal the chemical reactiveness of aloeresin-A through quantum chemical calculations. Hence, our findings show aloeresin-A to be a promising candidate for effectively inhibiting keratitis. However, additional research is imperative for potential integration into lens care solutions.

show abstract

Contact Lens Safety for the Correction of Refractive Error in Healthy Eyes

Cited by 12 publications

References 67 publications

Unregulated Decorative Lenses: A Brief Definitive Review

Unregulated Decorative Lenses: A Brief Definitive Review

Synergistic Effect of Nilavembu Choornam–Gold Nanoparticles on Antibiotic-Resistant Bacterial Susceptibility and Contact Lens Contamination-Associated Infectious Pathogenicity

Multi-Target Effect of Aloeresin-A against Bacterial and Host Inflammatory Targets Benefits Contact Lens-Related Keratitis: A Multi-Omics and Quantum Chemical Investigation

Contact Info

Product

Resources

About