Contact Lens Sensor Human Trial and Conceptual in-vivo Validation of Rate-Based Classification Method for Normal Tension Glaucoma (NTG)

Karunaratne, I.K.; Lee, C. H. C.; Wei, Yifan; Zhang, Y.; Yu, Minbin; Lam, David Chuen Chun

doi:10.1109/gmepe/pahce50215.2021.9434865

2021 Global Medical Engineering Physics Exchanges/Pan American Health Care Exchanges (GMEPE/PAHCE) 2021

DOI: 10.1109/gmepe/pahce50215.2021.9434865

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Contact Lens Sensor Human Trial and Conceptual in-vivo Validation of Rate-Based Classification Method for Normal Tension Glaucoma (NTG)

I.K. Karunaratne

C. H. C. Lee

Yifan Wei

et al.

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“…Three inductor-capacitor resonant circuits were embedded in a silicone elastomer contact lens, which detects corneal curvature deformation. [12][13][14] Signals generated from the sensor are calibrated and transformed into IOP values. Previous studies demonstrated that the sensor can conformally track the IOP fluctuation of a silicone rubber model eye.…”

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A New Contact Lens Sensor System for Continuous Intraocular Pressure Monitoring: Evaluation of Safety and Tolerability

Zhang

Wei

Karunaratne

et al. 2022

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Purpose:To assess the safety and tolerability of a new contact lens sensor (CLS) system for continuous 3- and 24-hr intraocular pressure (IOP) monitoring in human eyes.Methods:Twenty-five subjects were recruited for 3-hr IOP measurement by CLS. Corneal fluorescein staining (CFS) scores were evaluated before and after measurement. Then, 30 participants (10 normal subjects and 20 glaucoma patients) were recruited for 24-hr IOP monitoring. Ocular surface disease index (OSDI) was assessed before and one day after measurement. Contact lens dry eye questionnaire-8 was assessed immediately after measurement. Visual analog scale of discomfort was measured before, immediately after, and one day after measurement. Best-corrected visual acuity (BCVA), tear break-up time (TBUT), and CFS were assessed before, immediately after, and 1 day after measurement.Results:All participants completed 3- or 24-hr IOP measurement by CLS. Corneal fluorescein staining increased from 0.6±0.7 to 2.4±1.5 after 3-hr IOP measurement (P<0.001). For participants undergoing 24-hr IOP monitoring, OSDI increased from 9.1±9.7 to 18.0±12.4 (P=0.001). CLDEQ-8 score was 11.6±5.8. Visual analog scale increased from 11.1±14.2 to 35.2±21.8 after measurement (P<0.001) and decreased to 26.7±18.4 one day later (P<0.001 compared with baseline). BCVA decreased from 1.0±0.01 to 0.8±0.1 (P<0.001) and returned to 0.9±0.1 after one day (P<0.001 compared with baseline). TBUT decreased from 5.1±3.9 to 2.6±1.5 s (P=0.001) and returned to 4.8±2.5 s (P=0.465 compared with baseline). Corneal fluorescein staining increased from 0.7±0.9 to 4.3±0.8 (P<0.001) and dropped to 0.8±0.7 (P=0.599 compared with baseline). No significant difference was found for all variations of indicators between normal subjects and glaucoma patients (P>0.1 for all comparisons).Conclusions:The CLS shows a great potential for a safe and tolerable 24-hr IOP monitoring in normal subjects and glaucoma patients. Clinical attention to the worsening signs and symptoms after measurement is required.

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mentioning

confidence: 99%

A New Contact Lens Sensor System for Continuous Intraocular Pressure Monitoring: Evaluation of Safety and Tolerability

Zhang

Wei

Karunaratne

et al. 2022

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

Self Cite

View full text Add to dashboard Cite

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Contact Lens Sensor Human Trial and Conceptual in-vivo Validation of Rate-Based Classification Method for Normal Tension Glaucoma (NTG)

Cited by 1 publication

References 9 publications

A New Contact Lens Sensor System for Continuous Intraocular Pressure Monitoring: Evaluation of Safety and Tolerability

A New Contact Lens Sensor System for Continuous Intraocular Pressure Monitoring: Evaluation of Safety and Tolerability

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