Contact Lenses for Drug Delivery

Ciolino, Joseph B.; Dohlman, Claes H.; Kohane, Daniel S.

doi:10.1080/08820530902802161

Cited by 60 publications

(42 citation statements)

References 31 publications

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“…A system in which the retention of the vehicle itself in the eye is prolonged in order that a drug reservoir can be maintained, as in the case of a contact lens, is therefore a promising potential solution. [20][21][22][23][24][25][26] Furthermore, because of the changing role of optometrists in prescribing drugs to manage eye diseases, 27,28 it is logical to extend optometric technology and practice into the therapeutics field. The increasing availability and clinical use of daily disposable contact lenses provides the platform for the development of viable singleday use drug delivery devices based on existing materials and lenses.…”

Section: Introductionmentioning

confidence: 99%

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

Mahomed

Tighe

2014

J Biomater Appl

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The poor retention and efficacy of instilled drops as a means of delivering drugs to the ophthalmic environment is well-recognised. The potential value of contact lenses as a means of ophthalmic drug delivery and consequent improvement of pre-corneal retention is one obvious route to the development of a more effective ocular delivery system. Furthermore, the increasing availability and clinical use of daily disposable contact lenses provides the platform for the development of viable single-day use drug delivery devices based on existing materials and lenses. In order to provide a basis for the effective design of such devices, a systematic understanding of the factors affecting the interaction of individual drugs with the lens matrix is required. Because a large number of potential structural variables are involved it is necessary to achieve some rationalisation of the parameters and physicochemical properties (such as molecular weight, charge, partition coefficients) that influence drug interactions. Ophthalmic dyes and structurally related compounds based on the same core structure were used to investigate these various factors and the way in which they can be used in concert to design effective release systems for structurally different drugs. Initial studies of passive diffusional release form a necessary precursor to the investigation of the features of the ocular environment that over-ride this simple behaviour. Commercially available contact lenses of differing structural classifications were used to study factors affecting the uptake of the surrogate actives and their release under "passive" conditions. The interaction between active and lens material shows considerable and complex structure dependence which is not simply related to equilibrium water content (EWC). The structure of the polymer matrix itself was found to have the dominant controlling influence on active uptake; hydrophobic interaction with the ophthalmic dye playing a major role.3

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Section: Introductionmentioning

confidence: 99%

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

Mahomed

Tighe

2014

J Biomater Appl

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“…[1][2][3] Owing to the physiologic and anatomic constraints of the eye, achieving the correct therapeutic concentration of a drug at the required site of action can be quite difficult. Eye drops are the most commonly used method of drug delivery to the eye, accounting for approximately 90% of all ophthalmic medical applications.…”

mentioning

confidence: 99%

Development and Efficacy of a Drug-Releasing Soft Contact Lens

Kakisu

Matsunaga²,

Kobayakawa

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The purpose of this study was to investigate the uptake and the release of antibiotics from a newly synthesized drug delivery hydrogel soft contact lens (SCL) using an ion ligand mechanism.METHODS. The antibiotics used were Gatifloxacin (GFLX) and Moxifloxacin (MFLX). The uptake amount and the sustained-release kinetics of antibiotics were investigated in vitro, and were also compared with newly synthesized SCLs, etafilcon A and polymacon. The antibiotic concentrations in the cornea, aqueous humor, and crystalline lens, and the effect against bacterial proliferation were investigated in vivo using rabbit subjects. Additionally the drug release efficacy of the new SCL was compared with that of eye drop administrations.RESULTS. In vitro, antibiotic uptake was increased with the weight percent (wt%) of the anionic group, and the released amount of antibiotics was highest during the initial 1 hour period, which then decreased over the next 72 hours. The released antibiotics volume of the new SCLs was significantly higher throughout 72 hours than that of the other two materials, etafilcon A and polymacon (P < 0.01). Whereas in vivo, the concentrations found in the cornea and aqueous humor were higher than those for the eye drop groups (P < 0.05 or P < 0.01). Antibiotic release at those sites decreased over 72 hours. No bacterial populations were detectable in the group treated with the new SCL presoaked in antibiotics throughout the experimental periods. CONCLUSIONS.The new SCLs released the antibiotics over several days, and showed improved penetration into the eye, along with prevention of bacterial proliferation.

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“…The creation of drug delivery systems such as a contact lens slow release of antibiotic might be a future option to solve this problem (43) . Another point to be addressed is biocompatibility.…”

Section: Future Perspectivesmentioning

confidence: 99%

Boston type I keratoprosthesis: Review

Magalhães

Sousa

Oliveira

2012

Arq. Bras. Oftalmol.

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Regardless of significant progress in the field of corneal transplantation to treat cor neal opacification, some cases of corneal blindness still present a poor prognosis for conventional penetrating keratoplasty. In patients with repeated graft fai lure and/or with severe ocular surface disease, the Boston type I keratoprosthesis (type I BKPro) has become a viable option. Modifications in its design and postoperative management have improved the longterm outcomes of visual acuity, retention, and postoperative infection rates. These advances made the type I BKPro be considered a safe alternative for visual rehabilitation in many patients with corneal pathologies. However, postoperative handle of chronic comorbidities, such as glaucoma, is still critical for preserving the visual gains achieved with BKPro.

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Contact Lenses for Drug Delivery

Cited by 60 publications

References 31 publications

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

Development and Efficacy of a Drug-Releasing Soft Contact Lens

Boston type I keratoprosthesis: Review

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