Contact Line Pinning Is Not Required for Nanobubble Stability on Copolymer Brushes

Bull, David S; Nelson, Natalie; Konetski, Danielle; Bowman, Christopher N.; Schwartz, Daniel K.; Goodwin, Andrew P.

doi:10.1021/acs.jpclett.8b01723

Cited by 27 publications

(26 citation statements)

References 57 publications

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“…Such nuclei may persist within the micro-/ nanoscale structures found on glass surfaces due to contact line pinning and may expand to form cavitation bubbles when mechanical shocks are imposed on the container. 26,27 Based on these observations, we hypothesize that a cavitationresistant surface should have low energy at the water interface, low roughness, and potentially a fluid-like structure to prevent stable contact line pinning. Hydrogels, three-dimensional hydrophilic polymeric networks, represent a material that possesses all of these attributes.…”

Section: Introductionmentioning

confidence: 98%

“…Even when surfaces are treated to increase hydrophilicity, the surface roughness inherent to glass containers allows the heterogeneous nucleation of gas bubbles, which in turn facilitate cavitation and subsequently protein damage and aggregation. Such nuclei may persist within the micro-/nanoscale structures found on glass surfaces due to contact line pinning and may expand to form cavitation bubbles when mechanical shocks are imposed on the container. , …”

Section: Introductionmentioning

confidence: 99%

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Hydrogel Coatings on Container Surfaces Reduce Protein Aggregation Caused by Mechanical Stress and Cavitation

Movafaghi

Daniels

Kelly

et al. 2021

ACS Appl. Bio Mater.

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This work reports the ability of hydrogel coatings to protect therapeutic proteins from cavitation-induced aggregation caused by mechanical stress. Here, we show that polyacrylamide hydrogel coatings on container surfaces suppress mechanical shock-induced cavitation and the associated aggregation of intravenous immunoglobulin (IVIg). First, crosslinked polyacrylamide hydrogels were grown on the surfaces of borosilicate glass vials. Treatment with ultrasound showed that these hydrogel surfaces suppressed cavitation events to levels below those found for unfunctionalized borosilicate glass. Next, IVIg solutions were loaded into these vials and subjected to tumbling, horizontal shaking, and drop testing. Aggregation was quantified by bisANS fluorescence staining and particle counting by flow imaging microscopy (FIM). In all cases, the presence of polyacrylamide hydrogels on the vial surfaces reduced the amount of IVIg aggregation and the number of particulates. In addition, the polyacrylamide appeared to have a protective effect that prevented additional aggregates from forming at extended tumbling times. Finally, drop test studies showed that the polyacrylamide coatings suppressed detectable cavitation. This work reveals how even a simple hydrogel vial coating can have a profound effect on stabilizing protein therapeutics.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Hydrogel Coatings on Container Surfaces Reduce Protein Aggregation Caused by Mechanical Stress and Cavitation

Movafaghi

Daniels

Kelly

et al. 2021

ACS Appl. Bio Mater.

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“…The fact that the surface nanobubble was able to move along on the substrate clearly demonstrated the stability of unpinned nanobubbles. Bull et al showed that the sites of nanobubble nucleation were randomly distributed on polymer brushes with hydrophobic and hydrophilic monomers, 4 indicating no preference for hydrophobicity. Using surface plasmon resonance microscopy, Wang et al 5 demonstrated that the migration of surface nanobubbles occurs after a series of stick−slip events.…”

Section: ■ Introductionmentioning

confidence: 99%

Effects of Gas Adsorption and Surface Conditions on Interfacial Nanobubbles

2021

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Gas aggregation and formation of interfacial nanobubbles (INBs) provide challenges and opportunities in the operation of micro-/nanofluidic devices. In the current study, we used molecular dynamics(MD) simulations to investigate the effects of hydrophobicity and various homogeneous surface conditions on gas aggregation and INB stability with a series of 3D argon–water–solid and water–solid systems. Among various signatures of surface hydrophobicity, the potential of mean force (PMF) minima exhibited the strongest correlation with the water molecular orientation at the liquid–solid interface, compared to the depletion layer width and the droplet contact angle. Our results indicated that argon aggregation on the substrate was a function of hydrophobicity as well as competition between gas–solid and water–solid PMFs. Thus, one precondition for gas aggregation on a surface is that the free energy minima of gas induced by the surface be much lower than that induced by water. We found that although the presence of gas molecules had little effect on the measures of wettability, it enhanced density fluctuations near liquid–solid interfaces. The PMF of gas along the surface tangential plane exhibited a small energy barrier between the epitaxial gas layer (EGL) in the bubble and the gas enrichment layer (GEL) in the liquid, which may benefit nanobubble stability. Much lower PMF in the EGL compared to that in the GEL indicated that gas molecules could migrate from the GEL to the nanobubble basement. However, density fluctuations enhanced by the GEL could reduce the energy barrier, thus reducing the stability of INBs.

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“…In this paper, we report a unique contrast agent that is designed to induce cavitation on the surface at low laser fluence and thus impart a nonlinear PA response while also maintaining a strong PA response in the linear regime. Previously, we showed that hydrophobically modified mesoporous silica nanoparticles facilitate acoustic cavitation by stabilizing the formation of gas pockets on the surface. − Here, gold nanorods with plasmon resonance in the near infrared (NIR) were coated first with silica and then covalently modified with hydrophobic alkyl chains. To impart dispersibility in aqueous solvents, the nanoparticles were resuspended with a monolayer of phospholipids (Figure ).…”

Section: Introductionmentioning

confidence: 99%

Hydrophobically Modified Silica-Coated Gold Nanorods for Generating Nonlinear Photoacoustic Signals

Mueller

Kuriakose

Ganguly

et al. 2021

ACS Appl. Nano Mater.

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In this work, we report that not only do gold nanorods coated with hydrophobically modified mesoporous silica shells enhance the photoacoustic (PA) signal over unmodified mesoporous silica-coated gold nanorods but also that the relationship between the PA amplitude and the input laser fluence is strongly nonlinear. Mesoporous silica shells of ∼14 nm thickness with ∼3 nm pores were grown on gold nanorods showing nearinfrared absorption. The silica shell was rendered hydrophobic with addition of dodecyltrichlorosilane and then resuspended in aqueous media with a lipid monolayer. Analysis of the PA signal revealed not only an enhancement of the PA signal compared to mesoporous silica-coated gold nanorods at lower laser fluences but also a nonlinear relationship between the PA signal and the laser fluence. We attribute each effect to the entrapment of solvent vapor in the mesopores: the vapor has both a larger expansion coefficient and a larger thermal resistance than silica that enhances conversion to acoustic energy, and the hydrophobic porous surface is able to promote a phase transition at the surface, leading to a nonlinear PA response even at fluences as low as 5 mJ cm −2 . At 21 mJ cm −2 , the highest laser fluence tested, the PA enhancement was >12-fold over mesoporous silica-coated gold nanorods.

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Contact Line Pinning Is Not Required for Nanobubble Stability on Copolymer Brushes

Cited by 27 publications

References 57 publications

Hydrogel Coatings on Container Surfaces Reduce Protein Aggregation Caused by Mechanical Stress and Cavitation

Hydrogel Coatings on Container Surfaces Reduce Protein Aggregation Caused by Mechanical Stress and Cavitation

Effects of Gas Adsorption and Surface Conditions on Interfacial Nanobubbles

Hydrophobically Modified Silica-Coated Gold Nanorods for Generating Nonlinear Photoacoustic Signals

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