Abstract. We obtain a basic inequality involving the Laplacian of the warping function and the squared mean curvature of any warped product isometrically immersed in a Riemannian manifold (cf. Theorem 2.2). Applying this general theory, we obtain basic inequalities involving the Laplacian of the warping function and the squared mean curvature of C-totally real warped product submanifolds of (κ, µ)-space forms, Sasakian space forms and non-Sasakian (κ, µ)-manifolds. Then we obtain obstructions to the existence of minimal isometric immersions of C-totally real warped product submanifolds in (κ, µ)-space forms, non-Sasakian (κ, µ)-manifolds and Sasakian space forms. In the last, we obtain an example of a warped product C-totally real submanifold of a non-Sasakian (κ, µ)-manifold, which satisfies the equality case of the basic inequality.