Contact Microradiographic Analysis of Feline Tooth Resorptive Lesions.

Ohba, Shigeo; Kiba, Hideo; Kuwabara, Masato; Yoshida, Hitoo; Koide, Fusaoki; Takeishi, Masatoshi

doi:10.1292/jvms.55.329

Cited by 9 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These are the sites where TR arises most commonly. 6 The outer surface of the tooth root and the associated alveolar bone are hydroxyapatite-rich. Periodontal bone is more labile than any other bone in the body 29 and, therefore, may be a site of greater deposition of and subsequent local availability of alendronate in hydroxyapatite.…”

Section: Discussionmentioning

confidence: 99%

“…Areas of TR are often well vascularized due to the invasion of granulation tissue and, thus, should be accessible to blood-borne alendronate. 6 [Butyl-4-14 C-]-alendronate concentrations measured by combustion were surprisingly high in whole teeth as compared to bone. The vascularized nature of bone allows broad distribution of the drug throughout the entire mass of the hard tissue.…”

Section: Progressingmentioning

confidence: 99%

“…Cats were dosed at 9AM, and food was restored at 1PM. Drug-treated animals received alendronate once weekly at a rate of 3.0 mg/kg from Week 0 through Week 22 as a solution in water by orogastric tube (Weeks 0-3) or as a solid tablet (Weeks [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Due to increasing resistance to dosing the cats, from Week 23 to the end of the study, the drug was formulated in tuna water and delivered by voluntary consumption.…”

Section: Inhibition Of Tooth Resorptionmentioning

confidence: 99%

See 2 more Smart Citations

Alendronate Binds to Tooth Root Surfaces and Inhibits Progression of Feline Tooth Resorption: A Pilot Proof-of-Concept Study

et al. 2009

View full text Add to dashboard Cite

Tissue distribution, bioavailability, and efficacy of alendronate in preventing progression of resorption of teeth were evaluated in cats. [Butyl-4-14C-]-alendronate accumulates on subgingival tooth and alveolar bone surfaces adjacent to vascularized tissue resulting in concentration of the drug around tooth roots. Three cats were treated with a 0.03 mg/kg i.v. bolus of [butyl-4-14C-]-alendronate followed by blood, urine, and feces collection and euthanasia 24-hours later. Drug tissue distribution was accessed by autoradiography and sample combustion. To assess bioavailability, 12 cats were administered alendronate orally (3.0 or 9.0 mg/kg in water or 9.0 mg/kg in tuna water) and urine was collected for 24-hours. In these formulations, alendronate oral bioavailability in cats was approximately 3%. In addition, 10 cats with radiographic evidence of pre-existing tooth resorption (14 affected teeth) were treated with vehicle or 3.0 mg/kg alendronate per os once weekly for 22-weeks and, then, 9.0 mg/kg per os twice weekly for 27-weeks in a random, masked study. Radiographic area of resorption was measured and progression scored every 3 to 4-months. In placebo-treated cats, resorption progressed in five of six teeth (+ 97% average increase in area of resorption), whereas progression of resorption was seen in only three of eight affected teeth in alendronate-treated cats with a -22% average change (decrease) in area (P < 0.01 difference in number of teeth showing progression; P < 0.001 difference in area of resorption). Alendronate accumulated preferentially on subgingival tooth surfaces and adjacent alveolar bone and, at a dose of 9 mg/kg twice weekly, effectively slowed or arrested the progression of resorption.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Progressingmentioning

confidence: 99%

Section: Inhibition Of Tooth Resorptionmentioning

confidence: 99%

See 1 more Smart Citation

Alendronate Binds to Tooth Root Surfaces and Inhibits Progression of Feline Tooth Resorption: A Pilot Proof-of-Concept Study

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Sasaki et al [8] demonstrated that various multinucleated odontoclasts appeared only in the deep/round lacunae root resorption in human deciduous teeth. In cats, however, odontoclasts were detected only at the peritubular areas but not in the deep of the resorption lacunae [4,5], and neither mononuclear cell nor cementoblasts were present on the surface of resirption area, being different from human deciduous teeth [8,9,11]. From the present findings some specific mineralization process was suggested for repairing of the dental root resorption area in feline cases, and the major resorption lesions might be located at the neck and not at in the root region of the permanent teeth in cats.…”

mentioning

confidence: 95%

“…We previously repoted in feline cases that numerous odontoclasts were assembled along the margin of resorption lacunae [4] and that resorption area was covered with fresh granulation tissue with infiltration of odontoclasts and capillary vessels [5]. Since few reports dealt with fine morphology of the superficial lesions of root resorption of feline teeth, this note is to see the lesions of permanent teeth in cats by scanning electron microscopy.…”

mentioning

confidence: 99%

Scanning Electron Microscopy of Root Resorption of Feline Teeth

Ohba

Kuwabara

Kamata

et al. 2004

The Journal of Veterinary Medical Science

Self Cite

View full text Add to dashboard Cite

ABSTRACT. Scanning electron microscopy was carried out on 10 feline extracted permanent teeth from 3 cases with root resorption. Various-sized resorption lacunae were well defined, showing an etched pattern and configuration as shown in human deciduous teeth. In cats, regardless of the shape and depth of lacunae, the resorption lacunae showed opening dentinal tubules in the wall with or without cement matrix apperring only in the deep and round lacunae of human cases. Some specific process of mineralization for repairing dental root resorption was suggested in cats. KEY WORDS: feline tooth, root resorption, SEM.

show abstract