Contact sensitization in children with atopic dermatitis

Özçeker, Deniz; Haşlak, Fatih; Dilek, Fatih; Sipahi, Sevgi; Yücel, Esra; Güler, Nermin; Tamay, Zeynep

doi:10.1016/j.aller.2018.06.002

Cited by 17 publications

(13 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most prevalent allergens in AT patients were found to be nickel sulphate, fragrance mix (I) 8%, balsam of Peru, thiomersal, and cobalt chloride. This finding was in agreement with previous studies which reported that nickel sulphate was also the most prevalent allergen in patient cohorts [ 38 – 40 ]. Similar results have been also previously reported for fragrance mix [ 41 – 43 ], balsam of Peru [ 44 – 47 ], thiomersal [ 48 ], and cobalt chloride [ 44 , 49 , 50 ].…”

Section: Discussionsupporting

confidence: 94%

The Effect of Atopy in the Prevalence of Contact Sensitization: The Experience of a Greek Referral Center

Tagka

Lambrou

Nicolaidou

et al. 2020

Dermatology Research and Practice

View full text Add to dashboard Cite

Contact dermatitis is a well-known skin condition, which is related to stimuli and environmental exposure to chemicals, affecting all ages as well as both genders. In the present work, we attempt to investigate the patterns of contact sensitization, with respect to the personal history of atopy (AT), in Greece in a large number of allergens, using patch testing. The retrospective analysis included clinical routine data of 1978 patients collected from 2014 to 2016 in the Laboratory of Patch Testing, National Referral Centre of Occupational Dermatoses. Sensitization, in all cases, was tested with 28 allergens of the European baseline series as adjusted to our local circumstances and clinical experience. A total population of 1978 patients was evaluated, with a male-to-female ratio of 0.45 (1359 females/619 males). From our patient cohort, 693 (35%) patients were evaluated with a history of atopy, while 1285 (65%) were nonatopic. The five most prevalent allergens in the total population without AT were nickel sulphate 5% (15.47%), fragrance mix (I) 8% (9.10%), balsam of Peru (6.47%), cobalt chloride 1% (4.70%), and thiomersal 0.1% (4.10%). Respectively, in the total population with AT, the five most prevalent allergens were nickel sulphate 5% (10.36%), fragrance mix (I) 8% (5.11%), balsam of Peru (3.29%), thiomersal 0.1% (3.03%), and cobalt chloride 1% (2.78%). Contact dermatitis surveillance is of great importance towards the clinical and systematic understanding of the disease. Further studies should be directed towards that end, in order to facilitate more effective health policies.

show abstract

Section: Discussionsupporting

confidence: 94%

The Effect of Atopy in the Prevalence of Contact Sensitization: The Experience of a Greek Referral Center

Tagka

Lambrou

Nicolaidou

et al. 2020

Dermatology Research and Practice

View full text Add to dashboard Cite

show abstract

“…Frequent use of emollients and topical medications were also recognized as a significant clinical problem in both children and adults with AD [35][36][37], including methylchloroisothiazolinone (wet wipes! ), cocamidopropyl betaine and wool alcohols (lanolin, Amerchol L-101), and fragrances [33,38,39]. These are also chemicals for which irritant patch test reactions are possible though.…”

Section: Allergic Contact Dermatitis and Atopymentioning

confidence: 99%

Contact Allergy in Children

Goossens

Morren

2020

Contact Dermatitis

View full text Add to dashboard Cite

Contact allergy in children is more frequent than previously suspected. Metals, ingredients of pharmaceutical and cosmetic products, preservatives/biocides, para-phenylenediamine, rubber additives, plastics and resins, and plants are known sensitizers in them. In adolescents, occupation-induced allergens may be involved as well. Sometimes unusual clinical presentations of allergic contact dermatitis can be observed. If there is a suspicion by history and clinical picture, or there is an unexplained eczema at particular body sites, patch testing should be performed at all ages. Patch testing in children is safe, but false-positive (as false-negative) reactions are, of course, possible. Patch test reactions must be interpreted carefully, particularly in atopic subjects, since their skin is readily irritated; this is especially the case for metals. An abbreviated baseline series, supplemented with relevant allergens from other test series, as well as contacted products and respective ingredients suggested by the history, should be patch tested.

show abstract

“…Лікування алергодерматозів передбачає: дотримання режиму дня та дієти, контроль за довкіллям щодо елімінації алергенних та неалергенних факторів, лікувально косметич ний догляд за шкірою, фармакотерапія систем на і місцева, фототерапія, фізіотерапія, лікуван ня супутніх захворювань, навчання пацієнтів, реабілітація і профілактика загострень [2,4,5,10,12].…”

Section: он мочульская тм косовскаяunclassified

“…Мембраностабілізуючі засоби, кротони (кромоглікат натрію, недокромил натрію) антимедіаторні препарати широкого спектра дії, які досить часто використовуються в ліку ванні алергодерматозів. Кромони стабілізують мембрани опасистих клітин і гальмують надхо дження іонів кальцію до клітин, унаслідок чого блокується розвиток алергічної реакції, зумо вленої взаємодією антитіла з антигеном, а також усувають гемокоагуляційні порушення та порушення мікроциркуляції [1,2,8,9,12]. Мембраностабілізуючі препарати признача ються як у комплексі з основними методами лікування, так і як профілактичне лікування в реабілітаційному періоді на тривалий термін протягом кількох тижнів і навіть місяців [2,4,10].…”

Section: он мочульская тм косовскаяunclassified

“…Імуносупресивна терапія, зокрема, цитос татичні засоби (циклоспорин А, азатіоприн, метотрексат) діють на транскрипцію генів, пригнічуючи проліферацію і активацію Т лім фоцитів, проліферацію В лімфоцитів, і зни ження активності NK клітин [1,2,6]. Цитоста тичні засоби застосовуються в разі хронічних тяжких алергодерматозів, резистентних до тра диційної терапії, інколи при гострих алергодер матозах із торпідним перебігом [3,6,12].…”

Section: он мочульская тм косовскаяunclassified

See 1 more Smart Citation

Systemic therapy of allergic dermatosis in children (literature review)

Mochulska¹,

Kosovska²

2021

MPU

View full text Add to dashboard Cite

Allergic pathology of skin is one of the most pressing problems of modern pediatry. The most common allergic dermatoses: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, toxicodermias, multiforme exudative erythema (Stevens-Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome). Many aspects of systemic treatment of allergic dermatoses in children are complex and controversial. The modern strategy of treatment of allergic dermatoses in children is based on the principles of evidence-based medicine. According to the international program documents EAACI (European Academy of Allergy and Clinical Immunology), AAAAI (American Academy of Allergy, Asthma & Immunology), PRACТALL (Practical Allergology Consensus Report) treatment of allergic dermatoses consists of: environmental control to eliminate allergenic and non-allergenic factors, skin care, systemic and local pharmacotherapy. Systemic pharmacotherapy includes using drugs of the following groups: antihistamines, glucocorticosteroids, membrane's stabilizators (kromons), leukotriene receptor antagonists, anti-IgE, cytostatics, sorbents, hepatoprotectors, probiotics, vitamins and minerals, antioxidants, sedative medications, enzymes, antibacterial, antifungal and antiviral, immunomodulatory and immunosuppressive medications. Purpose — to increase information on modern possibilities of systemic therapy of allergic dermatoses in children. Conclusions. Systemic pharmacotherapy of allergic dermatoses should be etiopathogenetic and influence the systemic mechanisms of allergic inflammation, which will help control the clinical course of the disease, reduce disability, improve the life quality of patients. No conflict of interest was declared by the authors. Key words: children, allergy, allergic dermatoses, systemic therapy, internal therapy.

show abstract

Contact sensitization in children with atopic dermatitis

Abstract: Cutaneous sensitization can develop in children with atopic dermatitis, therefore allergic contact dermatitis should be kept in mind.

Cited by 17 publications

References 24 publications

The Effect of Atopy in the Prevalence of Contact Sensitization: The Experience of a Greek Referral Center

The Effect of Atopy in the Prevalence of Contact Sensitization: The Experience of a Greek Referral Center

Contact Allergy in Children

Systemic therapy of allergic dermatosis in children (literature review)

Contact Info

Product

Resources

About