Contact sensitization in patients with chronic venous leg ulcers in Singapore

Lim, Kar-Seng; Tang, Mark Boon Yang; Goon, Anthony Teik‐Jin; Leow, Yung Hian

doi:10.1111/j.1600-0536.2007.00987.x

Cited by 32 publications

(39 citation statements)

References 23 publications

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“…However, the use of antibiotic ointments in the treatment of colonized wounds is not recommended by International (8)(9) and Brazilian (11) clinical protocols. The use of topical medications for the treatment of wounds and the surrounding skin frequently causes allergic reaction in individuals with chronic ulcers of the LE, and these reactions are mentioned as being significant obstacles to healing (23,24) . Various studies have pointed out high rates of sensitization to contact with neomicine and other topical products used in patients with venous ulcers (23)(24)(25) .…”

Section: Discussionmentioning

confidence: 99%

Manejo clínico de úlceras venosas na atenção primária à saúde

et al. 2012

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Objective: To discuss the clinical management of venous ulcers in primary health care, based on the vision of users who live with this affliction. Methods: This was a qualitative, exploratory, descriptive study, conducted with 25 adult users in treatment in the Family Health Units. Data were collected in the second semester of 2008, using a structured instrument with questions of sociodemographic characteristics, type of cleaning, coverings, use of compression therapy, medication and prescribed guidelines. Results: Cleaning products are used that aggravate the granulation tissue, such as coverings with various substances, including sunflower oil and antibiotic ointments; the majority of users do not use measures to control edema. Conclusion: It is necessary to elaborate and adopt clinical protocols for the care of venous ulcers, as well as to provide ongoing education for health professionals. Keywords: Varicose ulcer; Wound healing; Primary health care; Bandages RESUMOObjetivo: Discutir o manejo clínico de úlceras venosas realizado na atenção primária à saúde, com base na visão dos usuários que convivem com esta afecção. Métodos: Estudo de natureza qualitativa exploratório, descritivo, realizado com 25 usuários adultos em tratamento nas Unidades de Saúde da Família. Os dados foram coletados no segundo semestre de 2008, utilizando-se um formulário estruturado com questões de caracterização sociodemográfica, tipo de limpeza, coberturas, uso de terapia compressiva, medicamentos e orientações prescritas. Resultados: São usados para a limpeza produtos que agridem o tecido de granulação, como coberturas com várias substâncias, dentre elas o óleo de girassol e pomadas antibióticas; a maioria dos usuários não utiliza medidas para controle do edema. Conclusão: fazem-se necessárias a elaboração e a adoção de protocolos clínicos para o cuidado com úlceras venosas, bem como a capacitação permanente dos profissionais de saúde. Descritores: Úlcera varicosa; Cicatrização; Atenção primária à saúde; Bandagens RESUMENObjetivo: Discutir el manejo clínico de úlceras venosas realizado en la atención primaria a la salud, con base en la visión de los usuarios que conviven con esta afección. Métodos: Estudio de naturaleza cualitativa exploratorio, descriptivo, realizado con 25 usuarios adultos en tratamiento en las Unidades de Salud de la Familia. Los datos fueron recolectados en el segundo semestre del 2008, utilizándose un formulario estructurado con preguntas de caracterización sociodemográfica, tipo de limpieza, coberturas, uso de terapia compresiva, medicamentos y orientaciones prescriptas. Resultados: Son usados para la limpieza productos que agreden el tejido de granulación, como coberturas con varias sustancias, entre ellas el aceite de girasol y pomadas antibióticas; la mayoría de los usuarios no utiliza medidas para control del edema. Conclusión: Se hace necesaria la elaboración y la adopción de protocolos clínicos para el cuidado con úlceras venosas, así como la capacitación permanente de los profesionales de salud....

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Section: Discussionmentioning

confidence: 99%

Manejo clínico de úlceras venosas na atenção primária à saúde

et al. 2012

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“…Contact sensitisation in leg ulcer patients is very frequently reported in published studies . The spectrum of allergens causing contact dermatitis in chronic leg ulcer patients depends on the wound care practices in a given area.…”

Section: Introductionmentioning

confidence: 99%

Contact sensitivity in patients with venous leg ulcer: A multi‐centric Indian study

Rai

Shenoy

Viswanath

et al. 2018

International Wound Journal

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Venous leg ulcers are the most common form of non-healing leg ulcers. They are subjected to treatments such as topical medications, dressings, and compression therapies. This can lead to exposure to a number of allergens with subsequent sensitisation and contact dermatitis of the regional skin. This may contribute to the poor ulcer healing. To detect the various contact sensitisers in patients with venous leg ulcers through patch testing, patients from 6 centres across India with venous leg ulcers of longer than 6 weeks duration were enrolled for the study. They were patch tested using a special parch test kit with 27 antigens. A total of 172 patients were included in the study; 82 (48.2%) tested positive for at least 1 antigen. Among them, polyvalent sensitisation was noted in 71% of patients. Wood tar mix (10.4%) and the framycetin (8.7%) were the most common allergens. There is a high frequency of allergic sensitisation to various ingredients of topical therapies used in the venous ulcer management, which may interfere with wound healing. Avoiding them can help obtain a better therapeutic outcome.

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“…Chronic leg ulcers (CLUs) are common, affecting 1–7% of the population aged > 65 years and 0.12–1.1% of the population worldwide . Long duration of illness, a local inflammatory milieu, damage to the skin barrier, and the use of many topical medicaments and molecules that are strong sensitizers, together with occlusive bandages promoting skin penetration by allergens, frequently lead to contact sensitization (contact allergy), and consequently to allergic contact dermatitis . Previous studies have shown high frequencies of contact allergies to topical drugs and ointments.…”

mentioning

confidence: 99%