To mitigate the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 , US states enacted a suite of nonpharmaceutical interventions. School closures were among the most consistently applied of these interventions. Over a 10-day period in March, all 50 US states closed kindergarten-grade 12 schools and childcare centers; nearly all colleges and universities followed suit. These closures were unprecedented in scope, affecting 21 million children in childcare, 57 million students in kindergarten-grade 12, and 20 million college and university students.School closures were not limited to the US. By mid-April, 192 countries had closed schools, affecting more than 90% (nearly 1.6 billion) of the world's students. 1 With limited information regarding COVID-19 in children, state and local officials were guided by evidence from other respiratory viruses, such as influenza, in which children have a substantial role in transmission. Although the evidence on effectiveness is mixed, school closures have been promoted as effective mitigation strategies during pandemics. 2,3 Understanding the effect school closures had on COVID-19 outcomes in the spring of 2020 is crucial for informing preparations for the fall.In this issue of JAMA, Auger et al 4 estimate the association of school closures with COVID-19 incidence and mortality. In this complex study, the authors used interrupted time series analyses of data from all 50 states on the timing of school closures (and other nonpharmaceutical interventions), and daily COVID-19 incidence and death counts. The analyses compared the change in outcomes before and after school closure, adjusting for state-level measures of testing capacity, population density, health status, and social vulnerability. To estimate the absolute differences associated with school closure, the authors compared projected incidence and mortality had schools remained open vs the modeled outcomes for school closure.Auger et al 4 found that school closure was associated with a −62% (95% CI, −71% to −49%) relative change in COVID-19 incidence per week, corresponding to an estimated absolute difference of 423.9 (95% CI, 375.0 to 463.7) cases per 100 000. The authors also reported that school closure was associated with a −58% (95% CI, −68% to −46%) relative change in mortality per week, corresponding to an estimated absolute difference in mortality of 12.6 (95% CI, 11.8 to 13.6) deaths per 100 000. Extrapolating these results to the US population, the authors es-