Contact Urticaria and the Contact Urticaria Syndrome (Immediate Contact Reactions)

Amin, Smita; Lahti, Arto; Maibach, Howard I.

doi:10.1201/9780203426272.ch42

Cited by 4 publications

(6 citation statements)

References 141 publications

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“…[3] Maibach and Johnson defined Contact Urticaria Syndrome (CUS) as a group of inflammatory reactions of the skin, occurring within minutes after contact with the eliciting substance. [7] They further described the four stages of progression in CUS [Table 1]. [6]…”

Section: Introductionmentioning

confidence: 99%

Contact urticaria : Present scenario

2009

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Immunological contact urticaria is a hypersensitivity reaction that appears on the skin following contact with an eliciting substance. Recent advances in our understanding of the molecular mechanism and pathogenesis of this reaction have altered its classification, diagnosis, and treatment. We discuss classification, epidemiology, diagnosis, testing, and treatment options that are available to patients with contact urticaria.

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Section: Introductionmentioning

confidence: 99%

Contact urticaria : Present scenario

2009

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“…Non‐immunologic contact urticaria (NICU) is an immediate contact reaction and occurs without prior sensitization. Numerous compounds, such as foods, preservatives, fragrances, plant and animal products, metals, and miscellaneous, have caused NICU . The symptoms vary according to the site of exposure, concentration, vehicle, mode of exposure, and the substance itself.…”

mentioning

confidence: 99%

“…More than half of the individuals react with local erythema and edema to these substances within 45 min of application if the concentration is sufficiently high. Furthermore, NICU is often accompanied by itching, burning, and stinging sensations, common cause of consumer complaint for face and scalp products .…”

mentioning

confidence: 99%

Reactions of non‐immunologic contact urticaria on scalp, face, and back

Zhai

Zheng

Fautz

et al. 2011

Skin Research and Technology

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“…sulfonated fatty acid salts like sodium lauryl sulfate) [1,2] and chemicals like nicotinic acid esters [3,4] . Nonimmunologic contact urticaria (NICU) is the most common form of immediate contact reaction resulting in a rapid infl ammatory response that does not require previous sensitization [5] . NICU-inducing substances include benzoic acid, sorbic acid and nicotinic acid derivatives, such as methyl nicotinate [5] .…”

Section: Introductionmentioning

confidence: 99%

“…Nonimmunologic contact urticaria (NICU) is the most common form of immediate contact reaction resulting in a rapid infl ammatory response that does not require previous sensitization [5] . NICU-inducing substances include benzoic acid, sorbic acid and nicotinic acid derivatives, such as methyl nicotinate [5] . Methyl nicotinate is a water-soluble derivative of nicotinic acid that has been shown to rapidly induce a transient localized infl ammatory response [6] through vasodilation of dermal capillaries when applied to skin [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Establishing a Minimal Erythema Concentration of Methyl Nicotinate for Optimum Evaluation of Anti-Inflammatories

Jumbelic¹,

Liebel²,

Southall³

2006

Skin Pharmacol Physiol

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Topical administration of chemicals such as methyl nicotinate that induce erythema have been employed to measure the effectiveness of formulations containing anti-inflammatory agents. Prior studies have utilized a single concentration of methyl nicotinate, between 36.5 and 100 mM, for all test subjects in evaluations of topical formulations. However, individuals have different thresholds of response to methyl nicotinate; thus, a single concentration may not be appropriate for all individuals and could result in the apparent lack of anti-inflammatory activity of the formulation being evaluated. In the current study, we evaluated the use of a minimal erythema concentration (MEC) of methyl nicotinate, defined as the lowest concentration that produces a complete and even erythema at the test site, compared with a 36.5-mM concentration of methyl nicotinate. Hydroalcoholic gels containing the nonsteroidal anti-inflammatory drug ibuprofen were compared with placebo. Diffuse reflectance spectroscopy was employed to measure differences in cutaneous inflammatory response between the control (placebo)-treated group and the ibuprofen-treated group. When chemical erythema was induced using an MEC of methyl nicotinate, greater reductions in erythema were seen in ibuprofen-treated sites compared with sites treated with a 36.5-mM concentration of methyl nicotinate. In conclusion, for an accurate assessment method of erythema induced by methyl nicotinate, consideration should be given to determining the extent of response of an erythema-producing agent on an individual basis. An MEC of methyl nicotinate should be determined and employed for each individual to obtain more consistent and reliable efficacy results of anti-inflammatory activity.

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Contact Urticaria and the Contact Urticaria Syndrome (Immediate Contact Reactions)

Cited by 4 publications

References 141 publications

Contact urticaria : Present scenario

Contact urticaria : Present scenario

Reactions of non‐immunologic contact urticaria on scalp, face, and back

Establishing a Minimal Erythema Concentration of Methyl Nicotinate for Optimum Evaluation of Anti-Inflammatories

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