Contact urticaria with anaphylactic reactions caused by occupational exposure to iridium salt

Abstract

This paper presents the case of a non-smoking and non-atopic male, exposed to iridium chloride at work, who developed respiratory tract symptoms and contact urticaria. Application of iridium salt to normal skin caused contact urticaria. An iridium chloride prick test showed a positive reaction and a scratch test produced anaphylactoid reactions. Platinum salt allergy was excluded through prick testing with hexachloroplatinate solution. There is no previous report describing a case where an individual has a positive prick test reaction to iridium salts and simultaneously a negative one to platinum salts. The results are interpreted as immediate-type hypersensitivity (Type I allergy?) to iridium salt. The route of sensitization was probably through the airways. Further testing showed that iridium salt allergy could persist for at least 18 months after exposure ceases. 14 employees at the same factory were prick tested with iridium and platinum salts with negative results. Prick testing is recommended as a method of first choice when investigating a person with suspected iridium salt allergy.

Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study

“…Another potentials ource of toxicityt hat arises from the SABRE technique is the iridium catalyst itself. Whilst some data on the adverse effectso fi ridiums alts has been reported [9] , little information is known abouto rgano-iridium complexes. [10] Therefore, we present at horough investigation into the potential toxicity of the metal catalyst in conjunctionw iths olvent and substrate effects.…”

Indium and iridium allergy in patients exposed to dental alloys

“…Cutaneous allergic vasculitis following injection of indium 113m has been reported (19). Subjective symptoms on occupational exposure to iridium chloride have been described (20). A method to establish the qualitative composition of the dental alloys used has been developed (8), which will facilitate further studies of possible side-effects of dental alloys.…”

Spinal stimulator peri-electrode masses: case report

“…9,13 Reactions to platinum and iridium have been reported, largely limited to industrial workers with chronic exposure in recycling centers processing catalytic converters. 1,5,12 Testing should include evaluation for immediate and delayed hypersensitivity through skin prick and patch testing, respectively. 39 In our patient the reaction involved the entire length of the electrode within the spinal canal and was not isolated to the area around the contacts.…”