2012
DOI: 10.1074/jbc.m111.322909
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Contactin-associated Protein 1 (Caspr1) Regulates the Traffic and Synaptic Content of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)-type Glutamate Receptors

Abstract: Background:The strength of excitatory synapses is determined by the synaptic content of AMPA receptors. Results: We found that Contactin associated protein 1 (Caspr1) binds to AMPA receptors and regulates their neuronal cell surface and synaptic expression. Conclusion: Caspr1 is a binding partner for AMPA receptors, which regulates their traffic and synaptic targeting. Significance: Caspr1 is a new player in plasticity mechanisms in excitatory synapses.

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Cited by 30 publications
(32 citation statements)
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“…Measurements were performed in two to six independent preparations, and at least five cells per condition were analyzed for each preparation. Quantitative imaging quantification was performed as previously described (60).…”
Section: Methodsmentioning
confidence: 99%
“…Measurements were performed in two to six independent preparations, and at least five cells per condition were analyzed for each preparation. Quantitative imaging quantification was performed as previously described (60).…”
Section: Methodsmentioning
confidence: 99%
“…Cultures were prepared from hippocampal neurons using previously described methods (Goslin et al, 1998), with adaptations (Santos et al, 2012).…”
Section: Hippocampal Culturesmentioning
confidence: 99%
“…The procedure for purification of postsynaptic density fractions (PSDs) was adapted from (Peça et al, 2011), as previously described (Santos et al, 2012).…”
Section: Subcellular Fractionationmentioning
confidence: 99%
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