Contactless microfluidic pumping using microchannel-integrated carbon black composite membranes

Fu, Xiaotong; Gagnon, Zachary

doi:10.1063/1.4933349

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…The electrode channels are fabricated directly against patterned regions of PDMS/CB membranes. To locally pattern each membrane, we used a multistage soft lithographic process we have reported previously . Briefly, we fabricated a soft lithographic microchannel mold using a negative photoresist, SU‐8 3050 (Microchem Corp).…”

Section: Methodsmentioning

confidence: 99%

Microfluidic free‐flow zone electrophoresis and isotachophoresis using carbon black nano‐composite PDMS sidewall membranes

Mavrogiannis

Ibo

et al. 2016

Electrophoresis

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We present a new type of free-flow electrophoresis (FFE) device for performing on-chip microfluidic isotachophoresis and zone electrophoresis. FFE is performed using metal gallium electrodes, which are isolated from a main microfluidic flow channel using thin micron-scale polydimethylsiloxane/carbon black (PDMS/CB) composite membranes integrated directly into the sidewalls of the microfluidic channel. The thin membrane allows for field penetration and effective electrophoresis, but serves to prevent bubble generation at the electrodes from electrolysis. We experimentally demonstrate the ability to use this platform to perform on-chip free-flow electrophoretic separation and isotachophoretic concentration. Due to the small size and simple fabrication procedure, this PDMS/CB platform could be used as a part of an on-chip upstream sample preparation toolkit for portable microfluidic diagnostic applications.

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Section: Methodsmentioning

confidence: 99%

Microfluidic free‐flow zone electrophoresis and isotachophoresis using carbon black nano‐composite PDMS sidewall membranes

Mavrogiannis

Ibo

et al. 2016

Electrophoresis

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“…Each sensing unit is fabricated into the channel sidewalls and contains two metal electrodes separated from the flow channel by a PDMS/CB membrane (Figure 1a). To locally pattern each sidewall membrane, a previously reported multistage soft lithographic process was used [13]. Briefly, the soft lithographic microchannel mold was fabricated using a negative photoresist, SU-8 3050 (Microchem Corp., Newton, MA, USA).…”

Section: Sensor Microfabricationmentioning

confidence: 99%

Piezoresistive Conductive Microfluidic Membranes for Low-Cost On-Chip Pressure and Flow Sensing

Islam

Doria

et al. 2022

Sensors

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Over the last two decades, the field of microfluidics has received significant attention from both academia and industry. Each year, researchers report thousands of new prototype devices for use in a broad range of environmental, pharmaceutical, and biomedical engineering applications. While lab-on-a-chip fabrication costs have continued to decrease, the hardware required for monitoring fluid flows within the microfluidic devices themselves remains expensive and often cost-prohibitive for researchers interested in starting a microfluidics project. As microfluidic devices become capable of handling complex fluidic systems, low-cost, precise, and real-time pressure and flow rate measurement capabilities have become increasingly important. While many labs use commercial platforms and sensors, these solutions can often cost thousands of dollars and can be too bulky for on-chip use. Here we present a new inexpensive and easy-to-use piezoresistive pressure and flow sensor that can be easily integrated into existing on-chip microfluidic channels. The sensor consists of PDMS–carbon black conductive membranes and uses an impedance analyzer to measure impedance changes due to fluid pressure. The sensor costs several orders of magnitude less than existing commercial platforms and can monitor local fluid pressures and calculate flow rates based on the pressure gradient.

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“…Each sensing unit is fabricated into the channel sidewalls and contains two metal electrodes separated from the flow channel with a PDMS/CB membrane (Fig 1a). To locally pattern each sidewall membrane, a previously reported multistage soft lithographic process was used [13]. Briefly, the soft lithographic microchannel mold was fabricated using a negative photoresist, SU-8 3050 (Microchem Corp).…”

Section: Sensor Microfabricationmentioning

confidence: 99%

“…Therefore, a change in impedance at a given excitation frequency is largely not influenced by EIS itself, but rather by the physical deformation of the resistive element. The resistivity of PDMS/CB has been reported to be several orders of magnitude higher than both Gallium and 1X PBS [13,21,22]. Therefore, any change in sensor resistance will be due to the deformation induced change in PDMS/CB membrane resistance.…”

Section: Impedance Response To Membrane Deformationmentioning

confidence: 99%

Piezoresistive Conductive Microfluidic Membranes for Low-Cost On-Chip Pressure and Flow Sensing

Islam¹,

Doria²,

Gagnon³

2021

Preprint

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Over the last two decades, microfluidics has received significant attention from both academia and industry, and researchers report thousands of new prototype devices each year for use in a broad range of environmental, pharmaceutical, and biomedical engineering applications. While lab-on-a-chip fabrication costs have continued to decrease, the hardware required for monitoring fluid flows within microfluidic devices themselves remains expensive and often cost prohibitive for researchers interested in starting a microfluidics project. As microfluidic devices become capable of handling complex fluidic systems, low-cost, precise and real time pressure and flow rate measurement capabilities has become increasingly important. While many labs use commercial platforms and sensor, these solutions can often cost thousands of dollars and can be too bulky for on-chip use. Here we present a new inexpensive and easy -to-use piezoresistive pressure and flow sensor that can be easily integrated into existing on-chip microfluidic channels. The sensor consists of PDMS-Carbon black conductive membranes and uses an impedance analyzer to measure impedance change due fluid pressure. The sensor costs several orders of magnitude less than existing commercial platforms and can monitor local fluid pressures and calculate flow rates based on pressure gradient.

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Contactless microfluidic pumping using microchannel-integrated carbon black composite membranes

Cited by 10 publications

References 29 publications

Microfluidic free‐flow zone electrophoresis and isotachophoresis using carbon black nano‐composite PDMS sidewall membranes

Microfluidic free‐flow zone electrophoresis and isotachophoresis using carbon black nano‐composite PDMS sidewall membranes

Piezoresistive Conductive Microfluidic Membranes for Low-Cost On-Chip Pressure and Flow Sensing

Piezoresistive Conductive Microfluidic Membranes for Low-Cost On-Chip Pressure and Flow Sensing

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