• Nearly 60% of commercial payers reported having 1 or more step-therapy (ST) programs in 2010, making it one of the most popular pharmacy benefit management tools. However, adoption of ST is quickly outpacing understanding of its clinical, humanistic, and economic outcomes.• Previous reviews of drug cost management tools have reported drug cost savings from ST, highlighted higher discontinuation rates, and identified gaps in the literature related to inclusion of quality of care metrics. Prior critical reviews have focused primarily on the lack of inclusion of a broad range of relevant outcomes rather than on study quality, particularly internal validity.
What is already known about this subjectPharmaceuticalStep-Therapy Interventions: A Critical Review of the Literature Brenda R. Motheral, RPh, MBA, PhD ABSTRACT BACKGROUND: Adoption of step therapy (ST) is quickly outpacing the market's understanding of its clinical, humanistic, and economic outcomes. The broad scope of previous reviews of drug management programs has prohibited an in-depth discussion of the ST literature specifically.