The study reported here represents the first effort to apply the emerging science of Mind Genomics to the citizens of an entire state, with the goal of improving communication about the pandemic, doing so during the crisis, rather than as an academic exercise AFTER the virus.During the past decade, the increasing sophistication of marketers has moved from selling ideas to selling better lives through public messages, hopefully effective ones. The basic notion is quite simple; the more one knows about the customer with respect to the specific topic to be 'messaged, ' the more effective the message will be. Despite the simplicity of the idea, the actual implementation is fraught with problems from beginning to end.Marketers attempt to 'know' their customers, but for most topics the effort to know customers is expensive relative to the opportunity. For example, for most small items, such as shoes or dresses, or even houses, it costs much more to discover the proper messaging than the marketer is willing to pay. There emerges a culture of fast, qualitative research, if any research at all. The marketer hires a competent focus group or individual moderator, moves on with the test, and determines next steps, such as the proper words. This paper presents the first part of an attempt to understand the mind of the Arizona citizen with respect to COVID-19, in preparation for the upcoming vaccine, promised in 2021. The objective is to understand the motivating messages which 'reach citizens, ' not only in terms of actual messages, but themes which could be used later on to drive vaccination. The anti-vaxxer movement has gained strength over the years for various reasons, ranging from religious to conspiracy theory, as well as disbelief, and indifference [4][5][6][7].