Contaminant exposure and effects in Baltic ringed and grey seals as assessed by biomarkers

Nyman, Madeleine; Bergknut, Magnus; Fant, Marie Louise; Raunio, Hannu; Jestoi, Marika; Bengs, Charlotta; Murk, Albertinka J.; Koistinen, Jaana; Bäckman, Christina; Pelkonen, Olavi; Tysklind, Mats; Hirvi, Timo; Helle, Eero

doi:10.1016/s0141-1136(02)00218-0

Cited by 92 publications

(83 citation statements)

References 71 publications

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“…Increases in the circulating vitamin A after exposure to PCBs have already been reported in rats and were linked to a reduction of hepatic retinoid stores (Bank et al, 1989;Zile , 1992), suggesting an enhanced mobilisation of hepatic vitamin A in PCB exposed animals. A reduction of hepatic retinoid stores following PCB exposure has also been observed in fish (Boyer et al, 2000), birds (Bishop et al, 1999;Murk et al, 1994) and aquatic mammals Nyman et al, 2003). Although several in vivo and in vitro studies showed that the activity of different liver enzymes involved in the retinoid metabolism were modified following PCB exposure (Fig.…”

Section: Relationships Between Pcbs Ho-pcbs and Vitamin Amentioning

confidence: 84%

“…By contrast, Mos et al (2007) found negative associations between PCBs and vitamin A levels in blubber of harbour seal pups exposed to similar PCB concentrations to the present study. Although Nyman et al (2003) observed positive correlations between PCBs in liver and circulating vitamin A, they reported negative relationships between liver and blubber vitamin A contents and hepatic PCBs levels in grey seals. These studies suggested an increased mobilisation of vitamin A stores from the liver, but also from the blubber, leading to the depletion of vitamin A levels in these tissues and an increase of vitamin A in blood.…”

Section: Relationships Between Pcbs Ho-pcbs and Vitamin Amentioning

confidence: 88%

“…The introduction of important factors, such as the period of lactation, in our LMM allowed the exclusion of the effects of time and thus, body mass and adipose lipid stores loss associated with lactation. Although several studies have already examined the relationships between vitamin A and PCBs or OCPs in seals (Nyman et al, 2003;Jenssen et al, 2003;Mos et al, 2007;Vanden Berghe et al, 2010), this is the first study to explore the relationships between vitamin A and PBDEs, HO-PCBs and MeO-PBDEs in lactating seals.…”

Section: Discussionmentioning

confidence: 99%

“…Most of these studies focussed on the impact of PCBs, and to a lesser extent of DDTs, HCB and PBDEs on vitamin A metabolism. Studies on laboratory and wild animals generally report depleted hepatic and adipose tissue retinoid stores as well as increased levels in the kidneys (Zile, 1992;Håkansson et al, 1994;Hallgren et al, 2001;Nyman et al, 2003;Ellis-Hutchings et al, 2006;Mos et al, 2007;Nová k et al, 2008). In plasma, both an increase and a decrease of vitamin A levels have been observed, probably depending on the species, the physiological state and the concentrations at which the animals were exposed (Zile, 1992;Nyman et al, 2003;Nová k et al, 2008;Cesh et al, 2010;Delport et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…While several studies investigated the effects of PCBs and DDTs on vitamin A metabolism in marine mammals (Nyman et al, 2003;Tornero et al, 2006;Mos et al, 2007;Routti et al, 2010b;Vanden Berghe et al, 2010), to our knowledge, none focussed on the relationships between vitamin A levels and PBDE contamination. However, PCBs and PBDEs share similar chemical properties and comparable adverse effects have been reported in several marine mammal species (Hall et al, 2003;Beineke et al, 2005;Peden-Adams et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Effects of polychlorobiphenyls, polybromodiphenylethers, organochlorine pesticides and their metabolites on vitamin A status in lactating grey seals

Berghe

Weijs

Habran

et al. 2013

Environmental Research

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a b s t r a c tPolychlorobiphenyls (PCBs), polybromodiphenylethers (PBDEs) and organochlorine pesticides (OCPs), such as dichlorodiphenyltrichloroethane (DDT) and hexachlorobenzene (HCB), are considered as endocrine disruptors in laboratory and wild animals. This study investigated whether these compounds and their hydroxylated metabolites (HO-PCBs and HO-PBDEs) may affect the homoeostasis of vitamin A, a dietary hormone, in the blubber and serum of twenty lactating grey seals sampled at early and late lactation on the Isle of May, Scotland. The effect of naturally produced compounds such as the methoxylated (MeO)-PBDEs was also examined. Vitamin A levels in inner blubber (37 7 9 mg/g wet weight (ww) and 92 7 32 mg/g ww at early and late lactation, respectively) and serum (408 7 143 and 390 7 98 ng/ml at early and late lactation, respectively) appeared to be positively related to SPCBs, SPBDEs and several individual PCB and PBDE congeners in inner blubber and serum. These findings may suggest enhanced mobilisation of hepatic retinoid stores and redistribution in the blubber, a storage site for vitamin A in marine mammals. We have also reported that serum concentrations of SHO-PCBs and 4-OH-CB107 tended to increase with circulating vitamin A levels. Although the direction of the relationships may sometimes differ from those reported in the literature, our results are in agreement with previous findings highlighting a disruption of vitamin A homoeostasis in the blubber and bloodstream following exposure to environmental pollutants. The fact that vitamin A and PCBs appeared to share common mechanisms of mobilisation and transfer during lactation in grey seals (Debier et al., 2004;Vanden Berghe et al., 2010) may also play a role in the different relationships observed between vitamin A and lipophilic pollutants.

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