Contamination, distribution, and risk assessment of antibiotics in the urban surface water of the Pearl River in Guangzhou, South China

Wang, Chang; Zhao, Yanping; Liu, Shuang; Xiao, Qin; Liang, Wei; Song, Yanfang

doi:10.1007/s10661-021-08887-5

Cited by 20 publications

(4 citation statements)

References 63 publications

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“…This is of significance because high cumulative doses, administration during early pregnancy, and the use of a broad-spectrum antibiotic have been shown to be associated with childhood asthma risk, but information regarding adults is lacking ( 40 ). Third, we did not consider the contribution of antibiotic residues in food, especially meat, and water, which may have been present because subclinical doses of antibiotics are used to promote animal growth ( 41 – 44 ). Fourth, the association between asthma and antibiotic exposure is just one component of a complex network.…”

Section: Discussionmentioning

confidence: 99%

Relationships between antibiotic exposure and asthma in adults in the United States: results of the National Health and Nutrition Examination Survey between 1999 and 2018

Li¹,

Chen²,

Huang³

et al. 2023

Front. Public Health

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ObjectivesTo investigate the relationship between antibiotic exposure and asthma in adults in the United States.MethodsData was obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2018. A total of 51,124 participants were included, excluding those who were aged < 20 years, female participants who were pregnant, and individuals who did not complete the prescription medications questionnaire and the medical conditions questionnaire regarding asthma status. Antibiotic exposure was defined as the utilization of antibiotics within the past 30 days, categorized based on the Multum Lexicon Plus therapeutic classification system. Asthma was defined as having a history of asthma or having an asthma attack or wheezing symptoms in the past year.ResultsThe risk of asthma was found to be 2.557 (95% CI: 1.811, 3.612), 1.547 (95% CI: 1.190, 2.011) and 2.053 (95% CI: 1.344, 3.137) times greater in participants who had used macrolide derivatives, penicillin and quinolones in the past 30 days, respectively, compared with those not using antibiotics. After adjusting for demographic covariates and asthma-related factors, only macrolides derivatives were significantly associated with asthma in the 20–40 and 40–60 age groups. For individuals over 60 years old, quinolones were significantly associated with asthma. The effect of different types of antibiotic with asthma varied in male and female populations. Moreover, higher socioeconomic status, greater BMI, younger age, smoking habits, history of infection, chronic bronchitis, emphysema, and family history of asthma were all identified as risk factors for asthma.ConclusionOur study indicated that three types of antibiotics were significantly associated with asthma in different subgroups of the population. Therefore, the use of antibiotics should be more strictly regulated.

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Section: Discussionmentioning

confidence: 99%

Relationships between antibiotic exposure and asthma in adults in the United States: results of the National Health and Nutrition Examination Survey between 1999 and 2018

Li¹,

Chen²,

Huang³

et al. 2023

Front. Public Health

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“…[6][7][8][9][10][11] These PPCPs are associated with a spectrum of adverse effects on human health, including mutagenicity, endocrine disruption, hepatotoxicity, carcinogenicity, disruptions in lipid homeostasis, reproductive disorders, allergies, and the promotion of antibiotic resistance gene transfer. 4,[12][13][14][15] There are further challenges with respect to the presence of these antimicrobial pollutants in the environment including the fact that traditional water and wastewater treatment methods have demonstrated limited efficacy in completely removing them from aquatic systems owing to their complex composition and widespread utilization. Also, there is dearth of information about the presence and distribution of these chemical substances in the aquatic systems in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

“…6–11 These PPCPs are associated with a spectrum of adverse effects on human health, including mutagenicity, endocrine disruption, hepatotoxicity, carcinogenicity, disruptions in lipid homeostasis, reproductive disorders, allergies, and the promotion of antibiotic resistance gene transfer. 4,12–15…”

Section: Introductionmentioning

confidence: 99%

Occurrence profiling, risk assessment, and correlations of antimicrobials in surface water and groundwater systems in Southwest Nigeria

Bolujoko,

Olorunnisola,

Poudel

et al. 2024

Environ. Sci.: Processes Impacts

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“…The concentrations of antibiotics in river waters range from a few nanograms per liter to a few micrograms per liter. For example, Wang et al (2021) found that the concentrations of MLs and sulfonamides (SAs) in the surface waters of the Pearl River are relatively high, ranging from 0.2 ng L -1 to 740 ng L -1 and accounting for 67% of the total concentration of 10 antibiotics detected in the waters. Zhang et al (2020) found that MLs are the main antibiotic contaminants in the Jiangsu section of the Yangtze River.…”

Section: Introductionmentioning

confidence: 99%

Occurrence and risk levels of antibiotic pollution in the coastal waters of eastern China

Shen

Jiang

et al. 2023

Environ Sci Pollut Res

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In order to preliminarily explore the distribution of antibiotic pollution in the coastal waters of eastern China, the concentrations of 13 antibiotics in 5 representative coastal rivers in Jiangsu and 21 sampling sites in the coastal waters of Jiangsu were analyzed. The total antibiotic concentrations in the 5 rivers ranged from 33.14 ng L -1 to 417.78 ng L -1 , and the total antibiotic concentrations in the 21 sampling sites ranged from 0.90 ng L -1 to 86.33 ng L -1 . The concentrations of antibiotics in a sampling site decreased as the distance of the sampling site from the coastline increased, indicating that river inputs are important sources of antibiotic pollution in the coastal waters of Jiangsu. The detection rates of roxithromycin, lincomycin, azithromycin, and sulfamethoxazole in the rivers and sampling sites were above 70%.Correlation analysis showed that the concentrations of antibiotics were positively correlated with the levels of total phosphorus and chemical oxygen demand. An ecological risk assessment revealed that roxithromycin posed a moderate risk to aquatic organisms in the coastal waters of Jiangsu. The results of this study highlight the signi cance of monitoring and controlling the concentrations of antibiotic contaminants in the coastal waters of Jiangsu.

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Contamination, distribution, and risk assessment of antibiotics in the urban surface water of the Pearl River in Guangzhou, South China

Cited by 20 publications

References 63 publications

Relationships between antibiotic exposure and asthma in adults in the United States: results of the National Health and Nutrition Examination Survey between 1999 and 2018

Relationships between antibiotic exposure and asthma in adults in the United States: results of the National Health and Nutrition Examination Survey between 1999 and 2018

Occurrence profiling, risk assessment, and correlations of antimicrobials in surface water and groundwater systems in Southwest Nigeria

Occurrence and risk levels of antibiotic pollution in the coastal waters of eastern China

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