Contamination of Health Care Personnel During Removal of Personal Protective Equipment

Tomas, Myreen; Kundrapu, Sirisha; Thota, Priyaleela; Sunkesula, Venkata; Cadnum, Jennifer L.; Mana, Thriveen Sankar Chittoor; Jencson, Annette; O’Donnell, Marguerite; Zabarsky, Trina F.; Hecker, Michelle; Ray, Amy J.; Wilson, Brigid; Donskey, Curtis J.

doi:10.1001/jamainternmed.2015.4535

Cited by 260 publications

(298 citation statements)

References 30 publications

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“…[4] and Tomas et al . [5] which suggested ongoing contamination due to incorrect doffing procedures.…”

Section: Discussionmentioning

confidence: 99%

“…Among these, the most frequently reported were deficiencies in administrative, engineering and environmental controls, inappropriate use or lack of personal protective equipment (PPE), defective IPC practice and behaviour, and poor employment conditions and social determinants [3]. Recent studies have also shown that the baseline skill levels of HCWs in PPE removal are poor, and result in contamination and risk to HCWs [4], [5].…”

Section: Introductionmentioning

confidence: 99%

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Personal protective equipment solution for UK military medical personnel working in an Ebola virus disease treatment unit in Sierra Leone

Reidy

Fletcher

Shieber

et al. 2017

Journal of Hospital Infection

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SummaryThe combination of personal protective equipment (PPE) together with donning and doffing protocols was designed to protect British and Canadian military medical personnel in the Kerry Town Ebola Treatment Unit (ETU) in Sierra Leone. The PPE solution was selected to protect medical staff from infectious risks, notably Ebola virus, and chemical (hypochlorite) exposure. PPE maximized dexterity, enabled personnel to work in hot temperatures for periods of up to 2 h, protected mucosal membranes when doffing outer layers, and minimized potential contamination of the doffing area with infectious material by reducing the requirement to spray PPE with hypochlorite.The ETU was equipped to allow medical personnel to provide a higher level of care than witnessed in many existing ETUs. This assured personnel working as part of the international response that they would receive as close to Western treatment standards as possible if they were to contract Ebola virus disease (EVD). PPE also enabled clinical interventions that are not seen routinely in West African EVD treatment regimens, whilst providing a robust protective barrier. Competency in using PPE was developed during a nine-day pre-deployment training programme. This allowed over 60 clinical personnel per deployment to practice skills in PPE in a simulated ETU and in classrooms. Overall, the training provided: (i) an evidence base underpinning the PPE solution chosen; (ii) skills in donning and doffing of PPE; (iii) personnel confidence in the selected PPE; and (iv) quantifiable testing of each individual's capability to don PPE, perform tasks and doff PPE safely.

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“…[4] and Tomas et al . [5] which suggested ongoing contamination due to incorrect doffing procedures.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Personal protective equipment solution for UK military medical personnel working in an Ebola virus disease treatment unit in Sierra Leone

Reidy

Fletcher

Shieber

et al. 2017

Journal of Hospital Infection

View full text Add to dashboard Cite

show abstract

“…These challenges include contamination of hands and wrists during glove removal, exposure and contamination of the neck during doffing, overheating and discomfort, gowns opening while in use, and a restricted field of vision, made worse by fogging inside the goggles 4 , 5 . Additional elements of complexity include the many steps in the protocol to don and doff this ensemble, as well as the multiplicity of sources for the products in the ensemble.…”

Section: The Designmentioning

confidence: 99%

Design Improvements for Personal Protective Equipment Used in Ebola and Other Epidemic Outbreaks

Glancey

Osei

Patterson

et al. 2017

Glob Health Sci Pract

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“…The RNA phages MS2, GA, Qβ, FI, SP, and PP7 are still efficiently used as surrogate models for the control of viral contamination in food production and storage, in industrial and clinical applications, and on health care personnel [for two recent examples, see [43,44]], in addition to serving as viral and microbial source tracking materials in wastewater [for references and discussion, see [45]]. It is broadly accepted that RNA phages are fully adequate surrogates for human enteroviruses in studies of virus contamination [46,47].…”

Section: Family Of Rna Phagesmentioning

confidence: 99%

The True Story and Advantages of RNA Phage Capsids as Nanotools

et al. 2016

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RNA phages are often used as prototypes for modern recombinant virus-like particle (VLP) technologies. Icosahedral RNA phage VLPs can be formed from coat proteins (CPs) and are efficiently produced in bacteria and yeast. Both genetic fusion and chemical coupling have been successfully used for the production of numerous chimeras based on RNA phage VLPs. In this review, we describe advances in RNA phage VLP technology along with the history of the Leviviridae family, including its taxonomical organization, genomic structure, and important role in the development of molecular biology. Comparative 3D structures of different RNA phage VLPs are used to explain the level of VLP tolerance to foreign elements displayed on VLP surfaces. We also summarize data that demonstrate the ability of CPs to tolerate different organic (peptides, oligonucleotides, and carbohydrates) and inorganic (metal ions) compounds either chemically coupled or noncovalently added to the outer and/or inner surfaces of VLPs. Finally, we present lists of nanotechnological RNA phage VLP applications, such as experimental vaccines constructed by genetic fusion and chemical coupling methodologies, nanocontainers for targeted drug delivery, and bioimaging tools.

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Contamination of Health Care Personnel During Removal of Personal Protective Equipment

Cited by 260 publications

References 30 publications

Personal protective equipment solution for UK military medical personnel working in an Ebola virus disease treatment unit in Sierra Leone

Personal protective equipment solution for UK military medical personnel working in an Ebola virus disease treatment unit in Sierra Leone

Design Improvements for Personal Protective Equipment Used in Ebola and Other Epidemic Outbreaks

The True Story and Advantages of RNA Phage Capsids as Nanotools

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