Contamination of Pharmaceutical and Personal Care Products in Sewage Treatment Plants and Surface Waters in South Korea and their Removal during Activated Sludge Treatment

Kim, Joon‐Woo; Ishibashi, Hiroshi; Hirano, Masashi; Jang, Hyo-Sang; Kim, Jong-Gu; Takao, Yuji; Ichikawa, Nobuhiro; Shinohara, Ryota; Arizono, Koji

doi:10.5985/jec.20.127

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…The third is the introduction of ozone and powder-activated carbon treatment in sewage treatment. This treatment has been reported to remove carbamazepine more efficiently (Azuma et al, 2019;Westerhoff et al, 2005) than other methods, including chlorine and activated sludge treatment (Stackelberg et al, 2007;Kubota et al, 2008;Kim et al, 2010). Monitoring the changes in pollution levels is an important and essential activity under environmental conservation.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Pharmaceutical concentrations and antimicrobial activity using hypersusceptible <i>Escherichia coli</i> lacking TolC component of multidrug efflux system in the Ayase River in Japan

Murahashi

Yamagishi

Nishino

et al. 2022

Fundam. Toxicol. Sci.

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The pharmaceutical concentrations and antimicrobial activity in the Ayase River were investigated. The water sources of the Ayase River are agricultural wastewater and effluent from septic tanks during the irrigation season and effluent from a sewage treatment plant and septic tanks during the non-irrigation season. Acetaminophen, bezafibrate, carbamazepine, clarithromycin, and diphenhydramine levels were in the range of 1.9-495 ng/L. During the irrigation season, pharmaceutical concentrations were higher downstream than upstream due to the inflow of agricultural wastewater in upstream areas. However, during the non-irrigation season, since most of the water sources were effluent from a sewage treatment plant and septic tanks, pharmaceutical concentrations were extremely high from upstream to downstream. The pharmaceutical concentrations during the non-irrigation season were at the same levels as those downstream of the Arakawa River, which was polluted by the effluent from Japan's largest sewage treatment plant. This extremely high pharmaceutical concentration in the non-irrigated season was found only in the Ayase River but not in the nearby Nakagawa and Furutone rivers, which are both urban water sources. The maximum concentration of clarithromycin in the Ayase River was higher than the predicted no-effect concentration for green algae, indicating that the water from the Ayase River may affect aquatic organisms. Antimicrobial activity analysis in the Ayase River using hypersusceptible Escherichia coli lacking the TolC component of the multidrug efflux system revealed that the river water had antimicrobial activity, suggesting potential risks, such as bactericidal action and development of antibiotic resistance in river water.

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Section: Antibacterial Activitymentioning

confidence: 99%

Pharmaceutical concentrations and antimicrobial activity using hypersusceptible <i>Escherichia coli</i> lacking TolC component of multidrug efflux system in the Ayase River in Japan

Murahashi

Yamagishi

Nishino

et al. 2022

Fundam. Toxicol. Sci.

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“…Triclosan concentrations in wastewater influents in Korea, United States, Europe, China, and Japan range from 148 to 785, 245 to 86,200, 142 to 2,301 and 55 to 1,000 ng/L, respectively [64,69,70]. Triclosan in wastewater effluents in Korea, United States, Europe, China, and Japan are detected at the concentrations between 0-127, 50-5,037, 10-2,210, 10.9-1,023, and 30-360 ng/L, respectively [1,2,10,64,69,[71][72][73][74]. In surface river water, triclosan was detected in Korea, United States, Europe, China, and Japan with reported values varying from 0 to 149, 3.5 to 34.9, < 0.2 to 285, 2.5 to 478 and 11 to 31, respectively [64,69,70,75].…”

Section: Source Occurrence Fate and Transport In The Environmentmentioning

confidence: 99%

“…Triclosan in wastewater effluents in Korea, United States, Europe, China, and Japan are detected at the concentrations between 0-127, 50-5,037, 10-2,210, 10.9-1,023, and 30-360 ng/L, respectively [1,2,10,64,69,[71][72][73][74]. In surface river water, triclosan was detected in Korea, United States, Europe, China, and Japan with reported values varying from 0 to 149, 3.5 to 34.9, < 0.2 to 285, 2.5 to 478 and 11 to 31, respectively [64,69,70,75]. A recent USGS study also reported that approximately 58% of 139 U.S. streams were contaminated with triclosan at the concentrations ranging from 0.14 to 2.3 μg/L [3].…”

Section: Source Occurrence Fate and Transport In The Environmentmentioning

confidence: 99%

Removal of a synthetic broad-spectrum antimicrobial agent, triclosan, in wastewater treatment systems: A short review

Lee

2015

Environmental Engineering Research

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Contaminants of emerging concern (CECs) including endocrine disrupting compounds (EDCs) and pharmaceuticals and personal care product chemicals (PPCPs) have recently received more attention because of their occurrence in water bodies and harmful impacts on human health and aquatic organisms. Triclosan is widely used as a synthetic broad-spectrum antimicrobial agent due to its antimicrobial efficacy. However, triclosan detected in aquatic environment has been recently considered as one of CECs, because of the potential for endocrine disruption, the formation of toxic by-products and the development of cross-resistance to antibiotics in aquatic environment. This comprehensive review focuses on the regulations, toxicology, fate and transport, occurrence and removal efficiency of triclosan. Overall, this review aims to provide better understanding of triclosan and insight into application of biological treatment process as an efficient method for triclosan removal.

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“…Pressurized liquid extraction, sonication and microwave-assisted extraction (Peysson and Vulliet 2013;Karageorgou et al 2014), matrix solid-phase dispersion (MSPD; Li et al 2016), and liquid-liquid extraction (US Environmental Protection Agency 2007) have been applied to extract CECs from solid samples. In general, these techniques are followed by a solid-phase extraction (SPE) clean-up step (US Environmental Protection Agency 2007; Economou et al 2009;Kim et al 2010;Peysson and Vulliet 2013) that may lead to complications and time consumption in sample processing. More recently, some microextraction techniques with simultaneous cleanup involving dispersive liquid-liquid microextraction, hollow-fiber liquid phase microextraction, and single-drop microextraction (Sharifi et al 2016) have been used for CECs.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Analysis of Multiclass Contaminants of Emerging Concern in Sediments by Liquid Chromatography with Tandem Quadrupole Mass Spectrometry

Rashid

Wang

et al. 2019

Enviro Toxic and Chemistry

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A quick, easy, cheap, effective, rugged, and safe (QuEChERS)‐based extraction and simultaneous dispersive solid‐phase extraction (dSPE) clean‐up method was developed for contaminants of emerging concern (CECs) in sediment samples. Hydration with a phosphate buffer (pH 2.0) and salting out with NaCl and MgSO4 facilitated the extraction and liquid–liquid portioning of the aqueous and organic phases. Cleanup of the extracts was achieved by florisil and C18 (1:1) sorbents in dSPE with minimal compromise of the analytes. The extracts were clean enough for determination by liquid chromatography–tandem mass spectrometry (LC‐MS/MS). The procedure was validated for preservatives, blood lipid regulators, analgesics and anti‐inflammatory drugs, plasticizers, and other classes of CECs in sediment matrix spiked at 6 levels between 1‐ and 40‐fold concentrations for CECs of varying analytical sensitivities. The recovery values were generally between approximately 27 and 120% and the relative standard deviation (%RSD) values were below 20% at 10‐ , 20‐ , and 40‐fold spiking levels, albeit the recoveries for some analytes dropped at low spike concentrations. The method showed high sensitivity where the method detection limits (MDLs) were at low ppb levels for the majority of the analytes that ranged between 0.002 and 1.93 µg/kg. The method performance was also compared with well‐established US Environmental Protection Agency (USEPA) Method 1694 by analyzing sediment samples collected from Yundang Lagoon (Xiamen, China) with field‐incurred CEC residues. The sediment samples were detected with residues of parabens, gemfibrozil, ketoprofen, naproxen, fenoprofen, diclofenac, miconazole, carbamazepine, benzophenon‐3, glibenclamide, sildinafil citrate, and some bisphenol analogues. Environ Toxicol Chem 2019;38:1409–1422. © 2019 SETAC

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Contamination of Pharmaceutical and Personal Care Products in Sewage Treatment Plants and Surface Waters in South Korea and their Removal during Activated Sludge Treatment

Cited by 7 publications

References 40 publications

Pharmaceutical concentrations and antimicrobial activity using hypersusceptible <i>Escherichia coli</i> lacking TolC component of multidrug efflux system in the Ayase River in Japan

Pharmaceutical concentrations and antimicrobial activity using hypersusceptible <i>Escherichia coli</i> lacking TolC component of multidrug efflux system in the Ayase River in Japan

Removal of a synthetic broad-spectrum antimicrobial agent, triclosan, in wastewater treatment systems: A short review

Simultaneous Analysis of Multiclass Contaminants of Emerging Concern in Sediments by Liquid Chromatography with Tandem Quadrupole Mass Spectrometry

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