Background: The disease spectrum of hospitalized crew-members could give good service to the support of health management. However, the disease spectrum of Chinese crew-members is still obscure. Methods: Four different database were searched with keywords. Papers were included and excluded using given rules. Data such as publishing year, investigation period, subject resources, total number of subjects, name of diagnosis, proportion of diseases were extracted for investigation. Then the investigation year(before 2010 or after 2011) was applied for sub-analysis in further research. Results: 24 results of disease spectrum of crew-members from numbers of hospitals were meta-analyzed. The first common disease was cervical and lumbar spine disorder which occupied 10% of diseases for hospitalization. And the other diseases followed it were hyperlipidemia(8%), cervical spine disease(7%), neurasthenia(6%), hypertension(6%), gastritis and duodenitis(6%), headache(6%), vegetative nerve functional disturbance(6%), upper respiratory infection(6%), fatty liver(5%), gastric and duodenal ulcers(4%), arrhythmia(4%), ground syncope(3%), urinary calculus(3%) and poor acceleration tolerance(2%), respectively. The spectrum of diseases was sub-analyzed by investigation year for further exploration. The proportion of cervical and lumbar spine disorder increased dramatically in the group of after 2011. Conclusion: Our work gave evidenced-based support for disease spectrum of crew-members, pointed research directions for treatment and prevention of crew-members’ common diseases, supported health strategy constitution of crew-members and guided well allocation of medical resources.