Contemporary alternatives to plant estrogens for menopause

Geller, Stacie E.; Studee, Laura

doi:10.1016/j.maturitas.2006.06.012

Cited by 53 publications

(42 citation statements)

References 65 publications

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“…Differences in findings across studies of the same product may be due to less than optimal trial design, variation in products and composition of products used, inadequate dosing, the length of treatment and small population size. Furthermore, any therapy claiming to reduce hot flushes should be assessed in blinded trials as placebo effects are high 54 . Furthermore, the placebo effect In our studies were high demonstrating the person's anticipation that an intervention will help them, and these effects should be considered in alternative therapies 55 .…”

Section: Discussionmentioning

confidence: 99%

Maca reduces blood pressure and depression, in a pilot study in postmenopausal women

et al. 2014

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Objective: Lepidium meyenii (Maca), a herbaceous plant, has been used for centuries for its fertility enhancing and aphrodisiac properties. In an Australian study, Maca improved anxiety and depressive scores. The effects of Maca on hormones, lipids, glucose, serum cytokines, blood pressure, menopausal symptoms and general well-being in Chinese postmenopausal women were evaluated Methods: A randomized, double-blind, placebo-controlled crossover study was conducted in 29 postmenopausal Hong Kong Chinese women. They received 3.3 g/day of Maca or placebo for 6 weeks each, in either order, over 12 weeks. At baseline, week 6 and week 12, estradiol, follicle stimulating hormone (FSH), sex hormone binding globulin (SHBG), thyroid stimulating hormone (TSH), full lipid profiles, glucose and serum cytokines, were measured. The Greene Climacteric, SF-36v2, Women's Health Questionnaire and Utian quality of life, scales were used to assess the severity of menopausal symptoms and health related quality of life.Results: There were no differences in estradiol, FSH, TSH, SHBG, glucose, lipid profiles and serum cytokines amongst those who received Maca as compared to placebo group, however, a significant decrease in both systolic and diastolic blood pressure was apparent after Maca treatment. The Greene Climacteric Scale revealed lower scores in the areas of psychological symptoms, including anxiety and depression following Maca. SF-36v2 showed stronger improvement in general and mental health when compared to baseline, whilst the women's health questionnaire showed improvement in depression and anxiety symptoms following Maca consumption. The Utian quality of life scoring did not show any differences in all domains tested.Conclusions: Maca does not exert hormonal or immune biological action in the small cohort of patients studies, however, it appears to reduce symptoms of depression and improve diastolic blood pressure in Chinese postmenopausal women. Although results are comparable to previous similar published studies in postmenopausal women, there might be a cultural difference among the Chinese postmenopausal women in terms of symptom reporting.

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Section: Discussionmentioning

confidence: 99%

Maca reduces blood pressure and depression, in a pilot study in postmenopausal women

et al. 2014

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“…It has been reported that compounds which are able to interact with hormonal function can have great potential to relieve hormonodependent related diseases (Saunier et al, 2011;Rashed et al, 2014). Many results claimed that plant extract with estrogenic activities can be used for management of menopausal symptoms (Geller and Studee, 2006;Xu et al, 2014). Furthermore, treatment with potential to decrease androgen hormone action is a good candidate for prostate disorders management (Grant and Ramasamy, 2012).…”

Section: Labcmentioning

confidence: 99%

Phytochemical composition, acute toxicity and phytohormonal activity of hydroalcoholic extract of Pentadesma butyracea (Clusiaceae Sabine (1824)) seeds

Basile¹,

Bayala²,

Maya³

et al. 2017

J. Med. Plants Res.

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Pentadesma butyracea is a rainforest species of Clusiaceae family with multi-values for human health care according to previous ethnobotanical survey. In spite of this traditional use of P. butyracea, there is a lack of scientific knowledge of its biological activities. Therefore, the aim of this study was to identify the major phytochemical compounds of P. butyracea hydroalcoholic seeds extract and to assess phyto-hormonal activities. Phyto-chemical screening of dichloromethane and hydroalcoholic seeds extracts were achieved. Subsequently, acute toxicity study was performed on mice to assess extracts safety use. Phyto-hormonal activities of hydroalcoholic extract of seeds were evaluated by uterotrophic and Hershberger's bioassays. Phyto-chemical screening of seeds of P. butyracea showed the presence of flavonoids, tannins, phytosterols, polyphenols, leucoanthocyanes and fatty acids. Acute toxicity investigation showed no mortality of mice at the dose of 2000 mg/kg. Hydro-alcoholic extract of seeds significantly increased (p<0.05) the weight of uterus of immature female mice while prostate and seminal vesicles weight of immature male mice were significantly (p<0.05) reduced. In conclusion, the hydroalcoholic extract of seeds of P. butyracea is practically nontoxic and contains chemical groups which induced estrogenic and anti-androgenic activities. The seeds extract of P. butyracea have great potential which could be useful for management of menopausal symptoms disorders and hormone-sensitive diseases.

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“…The World Health Organization estimated that 1.2 billion women would be 50 years or older by the year 2030 (1). Estrogen decline during menopause may cause various problems such as vasomotor instability, lowered psychometric functions, vaginal and urinary infections, and forgetfulness (2).…”

Section: Introductionmentioning

confidence: 99%

Quality of Sleep and Its Related Factors in Postmenopausal Women in West Tehran

Taavoni¹,

Ekbatani²,

Haghani³

2014

Women's Health Bull

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Background: Sleep disturbance is common in menopausal women. Objectives: This study aimed to measure the rate of self-reported sleep disturbance and to identify its associated factors in 50-60 year-old women. Patients and Methods:This cross-sectional study included 700 healthy volunteer women aged 50 to 60 years, who were in postmenopausal period for at least 1 year. The participants were interviewed after obtaining informed consents. The study questionnaire covered two main aspects of personal characteristics and the Pittsburgh Sleep Quality Index (PSQI). Data was analyzed using SPSS 14 software. Results: The frequency of sleep disturbance was 62.5%. A significant association was found between sleep disturbance and characteristics of occupation, education, financial status and husband's profession. There were no significant association between sleep disturbance and other personal characteristics, such as age, partner's age, number of children, family size and consumption of tea, coffee or cola. Conclusion: Sleep disturbance is common in menopausal women. Appropriate interventions based on sleep-related personal characteristics should be performed to improve sleep quality, which is very important for maintaining the quality of life.

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Contemporary alternatives to plant estrogens for menopause

Cited by 53 publications

References 65 publications

Maca reduces blood pressure and depression, in a pilot study in postmenopausal women

Maca reduces blood pressure and depression, in a pilot study in postmenopausal women

Phytochemical composition, acute toxicity and phytohormonal activity of hydroalcoholic extract of Pentadesma butyracea (Clusiaceae Sabine (1824)) seeds

Quality of Sleep and Its Related Factors in Postmenopausal Women in West Tehran

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