Contemporary approaches for imaging skeletal metastasis

Ulmert, David; Solnes, Lilja B.; Thorek, Daniel L.J.

doi:10.1038/boneres.2015.24

Cited by 39 publications

(29 citation statements)

References 88 publications

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“…Both PCa and BCa commonly metastasize to the skeleton, often manifesting a mixed bone-forming/resorbing phenotype that complicates detection because current clinical imaging methods rely on the uptake at sites with increased osteoblastic activity (21, 22). We evaluated the ability of 89 Zr-11B6 to detect both phenotypes using intraosseous LNCaP-AR (osteolytic) and VCaP (osteoblastic) bone metastases models with control PC3 (AR/hK2-negative osteolytic) bone lesions (Fig.…”

Section: Resultsmentioning

confidence: 99%

Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

et al. 2016

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Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. AR-regulated human kallikrein-related peptidase 2 (free hK2) is a prostate tissue-specific antigen produced in prostate cancer and androgen-stimulated breast cancer cells. Fluorescent and radio conjugates of 11B6, an antibody targeting free hK2, are internalized and noninvasively report AR pathway activity in metastatic and genetically engineered models of cancer development and treatment. Uptake is mediated by a mechanism involving the neonatal Fc receptor. Humanized 11B6, which has undergone toxicological tests in nonhuman primates, has the potential to improve patient management in these cancers. Furthermore, cell-specific SATA uptake may have a broader use for molecularly guided diagnosis and therapy in other cancers.

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Section: Resultsmentioning

confidence: 99%

Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

et al. 2016

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“…However, by monitoring bone activity, a pleotropic drug which affects bone remodeling rather than cancer cells may lead to misinterpretation of results. [10] Scan duration, resolution and artifactual uptake are challenges which can be overcome by more disease-specific targeted imaging techniques. [10]…”

Section: 2 Diagnostic Approach To Bone Metastasesmentioning

confidence: 99%

“…[10] Scan duration, resolution and artifactual uptake are challenges which can be overcome by more disease-specific targeted imaging techniques. [10]…”

Section: 2 Diagnostic Approach To Bone Metastasesmentioning

confidence: 99%

Bone Pain and Muscle Weakness in Cancer Patients

Milgrom

Lad

Koniaris

et al. 2017

Curr Osteoporos Rep

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Purpose of review In this article we will discuss the current understanding of bone pain and muscle weakness in cancer patients. We will describe the underlying physiology and mechanisms of cancer-induced bone pain (CIBP) and cancier-induced muscle wasting (CIMW), as well as current methods of diagnosis and treatment. We will discuss future therapies and research directions to help patients with these problems. Recent Findings There are several pharmacologic therapies that are currenly in pre-clinical and clinical testing that appear to be promising adjuncts to current CIBP and CIMW therapies. Such therapies include resiniferitoxin, which is a targeted inhibitor of nociptive nerve fibers, and selective androgen receptor modulators, which show promise in increasing lean mass. Summary CIBP and CIMW are a significant causes of morbidity in affected patients. Current management is mostly palliative; however, targeted therapies are poised to revolutionize how these problems are treated.

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“…22 PET techniques do offer, however, superior spatial resolution compared with bone scintigraphy and allow determination of standardized uptake values for quantitative longitudinal tumor tracking. 51 There are a number of tumor-specific tracers that have demonstrated effectiveness in the early detection of spinal cancer. MIBG ( 123 I-metaiodobenzylguanidine) is one such example and has become standard of care in the evaluation of skeletal involvement in neuroblastoma.…”

Section: Nuclear Imaging and Petmentioning

confidence: 99%

“…By targeting markers specific to the tumor type in question, there is less concern of imaging normal, inflammatory, or bone remodeling reactions. 51 For example, in an orthotopic bone metastasis mouse model of prostate cancer, 89Zr-5A10, which targets prostate specific antigen (PSA), targeted prostate cells without imaging bone remodeling. 50 In another experimental study, a novel PET tracer targeting the avb3 and avb5 integrins, which are overexpressed in bone metastases, showed rapid and specific uptake into bony metastases in a mouse model.…”

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confidence: 99%

Anatomic and functional imaging in the diagnosis of spine metastases and response assessment after spine radiosurgery

Soliman¹,

Taunk²,

Simons³

et al. 2017

FOC

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Spine stereotactic radiosurgery (SSRS) has recently emerged as an increasingly effective treatment for spinal metastases. Studies performed over the past decade have examined the role of imaging in the diagnosis of metastases, as well as treatment response following SSRS. In this paper, the authors describe and review the utility of several imaging modalities in the diagnosis of spinal metastases and monitoring of their response to SSRS. Specifically, we review the role of CT, MRI, and positron emission tomography (PET) in their ability to differentiate between osteoblastic and osteolytic lesions, delineation of initial bony pathology, detection of treatment-related changes in bone density and vertebral compression fracture after SSRS, and tumor response to therapy. Validated consensus guidelines defining the imaging approach to SSRS are needed to standardize the diagnosis and treatment response assessment after SSRS. Future directions of spinal imaging, including advances in targeted tumor-specific molecular imaging markers demonstrate early promise for advancing the role of imaging in SSRS.

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Contemporary approaches for imaging skeletal metastasis

Cited by 39 publications

References 88 publications

Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

Bone Pain and Muscle Weakness in Cancer Patients

Anatomic and functional imaging in the diagnosis of spine metastases and response assessment after spine radiosurgery

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