Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: Report from the SENTRY Antimicrobial Surveillance Program (1998–2004)

Moet, Gary J.; Jones, Ronald N.; Biedenbach, Douglas J.; Stilwell, Matthew G.; Fritsche, Thomas R.

doi:10.1016/j.diagmicrobio.2006.05.009

Cited by 328 publications

(159 citation statements)

References 25 publications

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“…Although A. baumannii is infrequently involved in skin and soft tissue infections (13), numerous studies have failed to assign A. baumannii a clear role in this condition because of the difficulty of discerning infection from skin and wound colonization (14). In our cases, A. baumannii was considered as a pathogenic bacterium because it was isolated from the skin samples after puncture, of which all were purulent.…”

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confidence: 99%

Outbreak of Multiresistant OXA-24- and OXA-51-Producing <i>Acinetobacter baumannii</i> in an Internal Medicine Ward

Tena

Martínez

Oteo³

et al. 2013

Jpn J Infect Dis

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SUMMARY:Here we describe the clinical, microbiological, epidemiological, and molecular characterization of an outbreak of multidrug-resistant Acinetobacter baumannii (MRAB) involving 5 patients admitted to the internal medicine ward of our hospital. Over a 6-week period, 5 MRAB isolates were recovered from 5 patients, including 1 with fatal meningitis, 3 with skin and soft tissue infections, and 1 with respiratory colonization. One sample obtained during environmental monitoring in the ward was A. baumannii-positive. According to the pulsed-field gel electrophoresis typing results, the strains isolated from all patients and the environmental sample belonged to a single clone, identified as ST79 by multilocus sequence typing. The bla OXA-24 and bla OXA-51 carbapenemases were detected in all isolates. Four patients died, but only the death of the meningitis patient was probably related to the A. baumannii infection. The infection source was probably the hands of the healthcare workers because the outbreak strain was isolated from the surface of a serum container. The results of the present study revealed the importance of strict adherence to control measures by all healthcare workers because the consequences of noncompliance can be very serious.

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mentioning

confidence: 99%

Outbreak of Multiresistant OXA-24- and OXA-51-Producing <i>Acinetobacter baumannii</i> in an Internal Medicine Ward

Tena

Martínez

Oteo³

et al. 2013

Jpn J Infect Dis

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“…As the causative agent of~90 % of all UTIs among ambulatory female patients (Johnson & Stamm, 1989), it is not surprising that the UTI subgroup of ExPEC has been studied the most extensively. Among SSTIs, E. coli is the third most prevalent species isolated (Moet et al, 2007). Nevertheless, strains from these infections have not been characterized extensively.…”

Section: Introductionmentioning

confidence: 99%

Colicin insensitivity correlates with a higher prevalence of extraintestinal virulence factors among Escherichia coli isolates from skin and soft-tissue infections

Petkovšek

Žgur-Bertok

Erjavec

2012

Journal of Medical Microbiology

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Colicins are toxic proteins with a narrow killing spectrum that are produced by colicinogenic Escherichia coli strains. The aim of this study was to analyse systematically whether extraintestinal virulence potential is linked to colicin (in)sensitivity. In total, 102 well-characterized E. coli isolates from skin and soft-tissue infections (SSTIs) were exposed to 17 single-colicinproducing strains, and the correlation between insensitivity to colicin and phylogenetic group as well as the extra-intestinal virulence potential of the SSTI strains was examined. The results showed that SSTI strains belonging to the B2 phylogenetic group were statistically significantly associated with insensitivity to at least ten colicins, and several colicin insensitivities were correlated with virulence factors. As far as is known, this is the first study to report such correlations. INTRODUCTIONEscherichia coli is a diverse bacterial species found naturally in the intestinal tract of humans and many other animal species. However, some strains are pathogenic and cause a wide variety of different intestinal as well as extra-intestinal diseases (Marrs et al., 2005). Extra-intestinal pathogenic E. coli (ExPEC) isolates are a medically significant group of pathogens responsible for significant morbidity, mortality and cost to the healthcare system as a result of urinary tract infections (UTIs), diverse intra-abdominal infections, pneumonia, surgical-site infections, meningitis, osteomyelitis, skin and soft-tissue infections (SSTIs) and bacteraemia (Russo & Johnson, 2006). As the causative agent of~90 % of all UTIs among ambulatory female patients (Johnson & Stamm, 1989), it is not surprising that the UTI subgroup of ExPEC has been studied the most extensively. Among SSTIs, E. coli is the third most prevalent species isolated (Moet et al., 2007). Nevertheless, strains from these infections have not been characterized extensively. All ExPEC strains have a common phylogenetic background deriving typically from phylogenetic groups B2 and D, and share the same spectrum of virulence determinants (Russo & Johnson, 2000).Colicins are narrow-killing-spectrum bacteriocins produced by E. coli. Each colicin is unique in its characteristics (see Table 1 for some examples) and they do not share the same killing efficiencies (Feldgarden & Riley, 1998). Whilst it has been shown that colicins prevent the growth of intestinal and uropathogenic E. coli isolates Schamberger et al., 2004; Stahl et al., 2004), a high prevalence of insensitivities to colicins among microbial populations isolated from animals, humans and patients with UTIs has also been reported (Feldgarden & Riley, 1998;Rijavec, 2010;Riley & Gordon, 1992). To our knowledge, the correlation between colicin insensitivity and virulence potential has not yet been investigated. Therefore, the prevalence of colicin insensitivity among E. coli SSTI isolates with known virulence potential was determined systematically by exposing 102 strains to 17 different colicins. Furthermore, for the first time,...

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“…Also, a study monitoring skin and soft tissue infections during a 7-year period and encompassing three continents (Europe, Latin America, and North America) showed E. coli to be an important causative agent. It was the third most prevalent isolated species, preceded solely by Staphylococcus aureus and Pseudomonas aeruginosa [13]. Consequently, we suggest that E. coli could have come from the patient's incompletely sterilized body, especially the thighs, which are near the anal region.…”

Section: Discussionmentioning

confidence: 99%

Sepsis With Multiple Abscesses After Massive Autologous Fat Grafting for Augmentation Mammoplasty: A Case Report

et al. 2010

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Background Autologous fat grafting to the breast for breast reconstruction and cosmetic breast augmentation has gained much attention recently. However, its efficacy and the severities of its associated complications are of concern. The authors experienced one case of multiple breast abscesses after augmentation mammoplasty by autologous fat grafting. Methods A 42-year-old woman presented to the authors' emergency department reporting tenderness, swelling, and a sensation of heat in both breasts. The patient had undergone augmentation mammoplasty by autologous fat grafting 7 days previously. Abscess formation was suspected based on the patient's history, physical examination, laboratory findings, and image study. Results Incision and drainage were performed immediately with the patient under general anesthesia, and 500 ml of a foul, brown, turbid, purulent fluid containing necrotic fat debris was drained from each breast. Empiric antibiotics were started on the first hospital day, and betadine and saline-irrigation were administered daily for 2 weeks. Incisions were closed on hospital day 19 when laboratory data and local infection signs had improved. At the patient's 9-month follow-up assessment, breast contours were found to be well preserved, and scarring was minimal. Conclusion Immediate complications such as edema, hematoma, and infection require serious consideration after autologous fat grafting in the breast. In particular, infection probably is the most serious complication because the volume of the fat injected is large and can induce systemic infections such as sepsis and distort the contours of the breast. To avoid such infections, systemic and multicenter studies are required to determine how fat grafting should be performed to minimize the risks of fat necrosis and infection.

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Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: Report from the SENTRY Antimicrobial Surveillance Program (1998–2004)

Cited by 328 publications

References 25 publications

Outbreak of Multiresistant OXA-24- and OXA-51-Producing <i>Acinetobacter baumannii</i> in an Internal Medicine Ward

Outbreak of Multiresistant OXA-24- and OXA-51-Producing <i>Acinetobacter baumannii</i> in an Internal Medicine Ward

Colicin insensitivity correlates with a higher prevalence of extraintestinal virulence factors among Escherichia coli isolates from skin and soft-tissue infections

Sepsis With Multiple Abscesses After Massive Autologous Fat Grafting for Augmentation Mammoplasty: A Case Report

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