Contemporary Concise Review 2018: Bronchiectasis

Chang, Anne B.; Grimwood, Keith

doi:10.1111/resp.13502

Cited by 1 publication

(1 citation statement)

References 87 publications

(113 reference statements)

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“…Asthma with distinct phenotypes has recently drawn increasing attention as a common and heterogeneous disease ( 1 , 3 ). Bronchiectasis is a common chronic respiratory disease in China ( 2 ) and is characterized by airway impairment, recurrent infections, and progressive damage to lung function ( 2 , 24 ). Recent studies have focused on bronchiectasis overlapping with other chronic respiratory diseases, especially asthma ( 13 ), and have demonstrated that the prevalence of asthma comorbid with bronchiectasis was notably high and increased from year to year ( 6 , 25 ).…”

Section: Discussionmentioning

confidence: 99%

Presence and sequence of bronchiectasis onset impact on the clinical characteristics in asthmatic patients

Sheng¹,

Wang²,

Yao³

et al. 2023

J Thorac Dis

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Background Asthmatic patients with comorbid bronchiectasis (ACB) show significantly severe condition with various inflammatory phenotypes; bronchiectasis is a heterogeneous disease caused by asthma and other multiple etiological factors. We aimed to investigate the inflammatory characteristics and their clinical significance in asthmatic patients according to the presence and onset time of bronchiectasis. Methods This prospective cohort study recruited outpatients with stable asthma. All the enrolled patients were divided into the non-bronchiectasis group and the ACB group, and the ACB group was separated into the bronchiectasis-prior group and the asthma-prior group. Demographic and clinical data were collected, and peripheral blood and induced sputum eosinophil counts, sputum pathogens, the fraction of exhaled nitric oxide (FeNO), lung function, and chest high-resolution computed tomography were examined. Results A total of 602 patients (mean age: 55.36±14.58 years) were included, of which 255 (42.4%) were males. Bronchiectasis was present in 268 (44.5%) patients, with 171 (28.41%) in the asthma-prior group and 97 (16.11%) in the bronchiectasis-prior group. For the asthma-prior group, the presence of bronchiectasis was positively correlated with age, presence of nasal polyps, severe asthma, ≥1 pneumonia in the last 12 months, ≥1 severe exacerbation of asthma in the last 12 months (SEA), peripheral blood eosinophil counts, and sputum eosinophil ratio; the extent and severity of bronchiectasis were positively correlated with ≥1 SEA and FeNO levels; and the bronchiectasis severity index (BSI) scores were positively correlated with ≥1 SEA and immunoglobulin E levels. For the bronchiectasis-prior group, bronchiectasis was positively correlated with previous pulmonary tuberculosis or pneumonia in childhood and ≥1 pneumonia in the last 12 months and negatively correlated with forced expiratory volume in one second (FEV 1 ) % and the FeNO level. The extent and severity of bronchiectasis were positively correlated with ≥1 pneumonia in the last 12 months and negatively correlated with FEV 1 %. The BSI scores were positively correlated with the duration of bronchiectasis. Conclusions The sequence of bronchiectasis onset may indicate distinct inflammatory characteristics and may be helpful in targeted therapy for patients with asthma.

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