Contemporary Concise Review 2019: Asthma

Wark, Peter

doi:10.1111/resp.13794

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Asthma is a common chronic inflammatory and heterogeneous pulmonary disease [1][2][3], characterized by reversible airway obstruction, chronic inflammation, hyper-responsiveness, and airway remodeling [4][5][6]. It affects 334 million people worldwide, with the highest prevalence in developed countries [1,7,8]. Based on the "inflammation theory", steroids could greatly relieve the symptoms in the early phase [5,9].…”

Section: Introductionmentioning

confidence: 99%

YKL-40 mediates airway remodeling in asthma via activating FAK and MAPK signaling pathway

Sun

Shi

Liu³

et al. 2020

Cell Cycle

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YKL-40 is a chitinase-like protein which was significantly elevated in asthma patients and related closely to asthma severity and airway remodeling. Airway remodeling in asthma involves complicated physical and pathological processes, including increased airway smooth muscle mass due to proliferation, migration of airway smooth muscle cells, epithelial-mesenchymal transition (EMT) and sub-epithelial fibrosis. However, the precise effect and underlying mechanism of YKL-40 in this pathological alteration remained unelucidated. In this study, we demonstrated that YKL-40 could promote asthma airway remodeling by increasing airway smooth muscle mass, inducing EMT and sub-epithelial fibrosis. Furthermore, we identified that FAK and MAPK signaling pathways are activated in the process. Inhibiting FAK or MAPK pathway could significantly ameliorate airway remodeling induced by excessive secretion of YKL-40 in vitro. and in vivo. In conclusion, this study shed light upon the effects of YKL-40 in asthma airway remodeling and provided potential novel targets in asthma patients with high YKL-40 level.

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Section: Introductionmentioning

confidence: 99%

YKL-40 mediates airway remodeling in asthma via activating FAK and MAPK signaling pathway

Sun

Shi

Liu³

et al. 2020

Cell Cycle

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Psychological correlates of bronchial asthma in young adults: The cognitive orientation approach

Roth¹,

Kreitler²

2020

Open J Asthma

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Asthma is a chronic infl ammatory disease with recurrent episodes of airfl ow obstruction, which is widespread but variable and usually reversible. It is characterized by a tendency of the bronchial tree to respond by bronchoconstriction, excessive secretion to different stimuli and edema [1]. The major symptoms are wheezing, diffi cult breathing, chest tightness and coughing that sometimes can be severe or even fatal [2]. It is a prevalent disease, which occurs in about 6% of the population, and affects people of all age groups, particularly those under 30. According to Global Burden of Disease Study [3] 324 million people worldwide live with asthma. Despite improved treatment modalities there has been a steady increase in the morbidity and mortality associated with asthma over the past decade [4]. The precise etiology of asthma is unknown. Infectious organisms, immunologic abnormalities, genetic, environmental as well as psychological factors were mentioned as likely to play a role in its etiology [5]. Asthma is one of the fi rst diseases whose psychological background was explored. The early studies were psychoanalytically oriented, and suggested a triple basis for asthma: an emotional component (mainly anxiety and latent aggressiveness), a personality component (i.e., insecurity, lack of self-confi dence, egocentricity, and a dependency confl ict between fear of closeness and fear of separation), and a psychopathological component (neuroticism, a compulsive personality disorder, and susceptibility to stress), all fostered and activated by overprotective but ambivalent parents [6-8]. Later research focused on many of these early insights

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Contemporary Concise Review 2019: Asthma

Cited by 2 publications

References 31 publications

YKL-40 mediates airway remodeling in asthma via activating FAK and MAPK signaling pathway

YKL-40 mediates airway remodeling in asthma via activating FAK and MAPK signaling pathway

Psychological correlates of bronchial asthma in young adults: The cognitive orientation approach

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