Contemporary Insights and Strategies for Risk Stratification and Prevention of Sudden Death in Hypertrophic Cardiomyopathy

Maron, Barry J.

doi:10.1161/circulationaha.109.878579

Cited by 270 publications

(238 citation statements)

References 105 publications

(185 reference statements)

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“…However, implantable cardioverter defibrillators, percutaneous alcohol ablation, and myectomy should be considered when patients experience serious outflow gradients (≥50 mm Hg), frequent presyncope/syncope, malignant arrhythmias, and refractory symptoms. 20,21,22 …”

Section: Outcome and Prognosismentioning

confidence: 99%

Two Hundred Eight Patients With Apical Hypertrophic Cardiomyopathy in China: Clinical Feature, Prognosis, and Comparison of Pure and Mixed Forms

Wang

et al. 2011

Clinical Cardiology

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Background: Apical hypertrophic cardiomyopathy (AHCM) is a relatively rare form of hypertrophic cardiomyopathy (HCM), originally described in Japan and later in the West. Limited information is available on this disease in China. Hypothesis: This study was designed to describe clinical features and prognoses of patients with AHCM in China. Methods: A retrospective study of 208 consecutive patients with AHCM examined at FuWai Hospital was performed. Clinical features, mortality, and cardiovascular morbidity were analyzed. Results: The 208 patients with AHCM represented 16.0% of all HCM patients. Among them, 64.4% were pure form and 35.6% were mixed form. Compared with the pure group, the mixed group had a significantly larger left atrial diameter and thicker apical thickness. One hundred ninety-nine patients had a mean follow-up of 8.0 ± 3.5 years, cardiovascular mortality was 1.0%, and annual cardiovascular mortality was 0.1%. The 2 cardiovascular deaths were both mixed form. The probability of survival was 97.0 ± 2% at 10 years. Of the patients, 17.8% had 1 or more cardiovascular events. The probability of survival without morbid events at 10 years was 77 ± 4%. Three independent predictors of cardiovascular morbidity were identified: age at diagnosis ≥60 years, left atrial diameter ≥36 mm, and New York Heart Association class ≥III at baseline. Conclusions:The prevalence of AHCM is relatively high, and it has a benign prognosis in China. However, 17.8% of patients may develop cardiovascular events. It is important to distinguish the 2 phenotypes of AHCM; the mixed form is less common but more serious than the pure form.

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Section: Outcome and Prognosismentioning

confidence: 99%

Two Hundred Eight Patients With Apical Hypertrophic Cardiomyopathy in China: Clinical Feature, Prognosis, and Comparison of Pure and Mixed Forms

Wang

et al. 2011

Clinical Cardiology

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“…Many patients have a normal life expectancy, whereas others may experience disease progression with profound exercise limitation, recurrent arrhythmias, and premature death largely caused by heart failure 5, 6. Sudden cardiac death (SCD) is relatively rare, occurs more commonly in young patients, and is mainly caused by ventricular arrhythmias that can be effectively treated with an implantable cardioverter‐defibrillator 7, 8…”

mentioning

confidence: 99%

Impact of Demographic Features, Lifestyle, and Comorbidities on the Clinical Expression of Hypertrophic Cardiomyopathy

Finocchiaro

Magavern

Sinagra

et al. 2017

JAHA

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“…Hence, it can be challenging to accurately identify risk factors which can improve the patient selection for prophylactic ICD therapy [17]. Contrast-enhanced CMR has emerged as an excellent tool for improving risk stratification of HCM patients.…”

Section: Late Gadolinium Enhancement and Scdmentioning

confidence: 99%

Cardiovascular magnetic resonance imaging in hypertrophic cardiomyopathy: Current state of the art

2016

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Contemporary Insights and Strategies for Risk Stratification and Prevention of Sudden Death in Hypertrophic Cardiomyopathy

Cited by 270 publications

References 105 publications

Two Hundred Eight Patients With Apical Hypertrophic Cardiomyopathy in China: Clinical Feature, Prognosis, and Comparison of Pure and Mixed Forms

Two Hundred Eight Patients With Apical Hypertrophic Cardiomyopathy in China: Clinical Feature, Prognosis, and Comparison of Pure and Mixed Forms

Impact of Demographic Features, Lifestyle, and Comorbidities on the Clinical Expression of Hypertrophic Cardiomyopathy

Cardiovascular magnetic resonance imaging in hypertrophic cardiomyopathy: Current state of the art

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