In the midst of an economy experiencing turmoil with uncertainty, it is required to produce a concept for building a solid economic system. This study aims to explain the strategy of the Islamic economic system in realizing the prosperity of the people in industry 4.0. This type of research uses a qualitative type with library research. While the research approach used is descriptive analysis. The data analysis used is using qualitative data analysis. The results of the study indicate that the Islamic economic system in Indonesia has not shown good and significant results in realizing the prosperity of the people. So that it requires steps and strategies in developing sharia economics, namely first, strengthening public awareness regarding sharia economic literacy, increasing and empowering Human Resources (HR) both in quality and quantity, and strengthening research and development (R&D) capacity. Second, Strengthening Fatwas, Regulations (Laws) and governance. Third, strengthening and expanding the halal network until the formation of halal in every region throughout Indonesia from upstream to downstream and the halal value chain. Fourth, strengthening the Islamic financial sector Strengthening the Islamic finance sector. Fifth, strengthening micro, medium and macroeconomic enterprises. Sixth, the strengthening and development of the economy based.