Contemporary Management of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Magistro, Giuseppe; Wagenlehner, Florian M. E.; Grabe, Magnus; Weidner, W.; Stief, Christian G.; Nickel, J. Curtis

doi:10.1016/j.eururo.2015.08.061

Cited by 236 publications

(231 citation statements)

References 57 publications

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“…While some previous reports highlight the differences between CP/CPPS and male BPS/IC, there is substantial overlap in the clinical presentation and pathogenesis [1,6]. Moreover, the complex, heterogeneous pathophysiology of CP/CPPS and BPS/IC is poorly understood [8,9]. Therefore, it is difficult to compare and contrast CP/CPPS and male BPS/IC.…”

Section: Introductionmentioning

confidence: 85%

“…A detailed definition of CP/CPPS is urologic pain or discomfort in the pelvic region, associated with urinary symptoms or sexual dysfunction with a duration of at least 3 of the last 6 months [9]. The differential diagnoses of pelvic pain, such as urinary tract infection, malignancy, anatomic abnormalities, or neurologic disorders, need to be excluded.…”

Section: Cp/cppsmentioning

confidence: 99%

“…The differential diagnoses of pelvic pain, such as urinary tract infection, malignancy, anatomic abnormalities, or neurologic disorders, need to be excluded. CP/CPPS is subclassified into either the inflammatory (NIH category IIIA) type or the noninflammatory (NIH category IIIB) type, based on the presence of leukocytes in the prostate samples [9,12]. The pain of CP/CPPS is most commonly localized to the perineum, suprapubic area, and penis; however, it can also be present in the testes, groin, or lower back [13].…”

Section: Cp/cppsmentioning

confidence: 99%

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Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Male Bladder Pain Syndrome/Interstitial Cystitis: How Are They Related?

Lee

2017

Urogenit Tract Infect

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To date, the heterogeneous pathophysiology of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and bladder pain syndrome/interstitial cystitis (BPS/IC) has not been fully elucidated. Thus, it is difficult to make a full comparison between CP/CPPS and male BPS/IC. Controversy and confusion surrounding the terminologies and classifications of CP/CPPS and BPS/IC complicates the issue. CP/CPPS and male BPS/IC are not mutually exclusive conditions, in that they have similarities in their pathogenesis and clinical presentation. Based on the working definitions of these terms, it would be correct to say that male BPS/IC is subsumed by CP/CPPS, and that male BPS/IC can be regarded as CP/CPPS with clear bladder-specific features. Although the term CP/CPPS may be inappropriate, especially since "CP" may be misleading, the perspective that CP/CPPS and male BPS/IC are male urological chronic pain syndromes could enhance the understanding of the relationship between the two. The European Association of Urology classification for chronic pelvic pain is systematic and corresponds well with our knowledge of chronic pain. Therefore, this classification might be the solution to the problems associated with the existing terminologies and taxonomy of CP/CPPS and BPS/IC. In the management of urological chronic pelvic pain in men, clinical phenotyping systems (the UPOINT or UPOINTs system) profile patients and indicate how tailored treatment could be achieved as individualized, multimodal therapeutic regimens. It would be prudent to include bladder-specific features, such as painful filling or painful urgency, in the criteria for the organ-specific domain of the UPOINT(s) system.

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Section: Introductionmentioning

confidence: 85%

Section: Cp/cppsmentioning

confidence: 99%

Section: Cp/cppsmentioning

confidence: 99%

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Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Male Bladder Pain Syndrome/Interstitial Cystitis: How Are They Related?

Lee

2017

Urogenit Tract Infect

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“…Magistro ve ark. 'ları, 28 randomize kontrollü çalışmayı değerlendirdikleri çalışmalarında monoterapinin etkili olduğu bir seçenek bulunmadığını bildirmişlerdir (11). Kısaca özetlemek gerekirse, antibiyotiklerin ya da α-blokerlerin bu grup hastada primer tedavi seçe-neği olması RKÇ tarafından desteklenmemektedir.…”

Section: Nonenfeksiyöz Prostatit Formlarıunclassified

“…Yine antienflamatuar ya da immün modüler ilaçların monoterapide etkili olmadığı; hormonal ilaçların da bu grup hastalara primer tedavi seçeneği olarak önerileme-yeceği bildirilmiştir. Öte yandan pregabalin, nörolojik yan etkileri nedeniyle tek başına ilk tedavi olarak önerilmezken; quercetin, cernilton gibi bazı fitoterapötik ajanların tekli ya da çoklu tedavilerde yararlı olabileceği gösterilmiştir (11). Bunun yanında, Pentozan polisülfat'ın tek başına ilk tedavi ajanı olamayacağı ve bu gruptaki bazı hastaların fizyoterapiden yararlanabileceği rapor edilmiştir (perineal ESWL, akupunktur, aerobik egzersiz) (11).…”

Section: Nonenfeksiyöz Prostatit Formlarıunclassified