Contemporary Management of Retroperitoneal Soft Tissue Sarcomas

Olimpiadi, Yuliya; Song, Siyu; Hu, James; Matcuk, George R.; Chopra, Shefali; Eisenberg, Burton L.; Sener, Stephen F.; Tseng, William W.

doi:10.1007/s11912-015-0462-0

Cited by 30 publications

(32 citation statements)

References 85 publications

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“…Aggressive multivisceral resection of involved organs is often necessary in order to achieve complete RPS extirpation with negative margins and the greatest chance for cure . Most frequently this includes retroperitoneal structures such as ipsilateral colon, kidney or psoas muscles/fascia.…”

Section: Introductionmentioning

confidence: 99%

Resection of retroperitoneal sarcoma en‐bloc with inferior vena cava: 20 year outcomes of a single institution

Blair

Reames

Singh

et al. 2018

Journal of Surgical Oncology

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Background: Margin negative resection offers the best chance of long-term survival in retroperitoneal sarcoma (RPS). En-bloc resection of adjacent structures, including the inferior vena cava (IVC), is often required to achieve negative margins. We review our 20-year experience of en-bloc IVC and RPS resection. Methods: Retrospective review of patients with RPS resection involving the IVC were matched 1:3 by age and histology to RPS without IVC resection. Prognostic factors for overall survival (OS) and disease free survival (DFS) were assessed. Results: Thirty-two patients underwent RPS resection en-bloc with IVC. They were matched with 96 cases of RPS without IV Cresection. Median OS of 59 months and DFS 18 months in IVC resection group was comparable to RPS resection without vascular involvement: median OS 65 months, DFS 18 months (P = 0.519, P = 0.604). On multivariate analyses, R2 margin (OS: HR = 6.52 [95%CI: 1.18–36.09], P = 0.032) was associated with inferior OS. R2 margin and increased number of organs resected (DFS: HR = 5.07, [1.15–22.27], P = 0.031, HR = 1.28 [1.01–1.62], P = 0.014) were associated with inferior DFS. Reconstructions included graft (n = 19, 59%), patch (n = 4, 13%), primary repair (n = 6, 19%), and ligation (n = 4, 13%). Conclusions: RPS resection en-bloc with IVC can achieve equivalent rates of DFS and OS to patients without vascular involvement.

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Section: Introductionmentioning

confidence: 99%

Resection of retroperitoneal sarcoma en‐bloc with inferior vena cava: 20 year outcomes of a single institution

Blair

Reames

Singh

et al. 2018

Journal of Surgical Oncology

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“…The optimal treatment for patients with localised, resectable retroperitoneal sarcomas is surgery with negative margins 4. Although negative microscopic margins (R0) are ideal, this is difficult to achieve technically from a surgery standpoint and to truly evaluate from a pathology standpoint for these often large tumours.…”

Section: Discussionmentioning

confidence: 99%

Acute haemorrhage from a retroperitoneal liposarcoma: a rare presentation

Sheikh

Simson²,

Obi-Njoku

et al. 2018

BMJ Case Reports

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A previously healthy 61-year-old Caucasian woman presented to the emergency department after collapsing at home with associated abdominal pain radiating to her back. An urgent CT angiogram was requested to rule out a ruptured aortic aneurysm. This showed a large 21 cm fat-containing lesion arising from the mid-pole of the left kidney, with an adjacent 4 cm perirenal haematoma. An initial diagnosis of a ruptured angiomyolipoma was made. Her haemoglobin was 105 g/L, with a creatinine of 104 mmol/L and an eGFR of 47 mL/min. Her clotting profile was normal. Following resuscitation, she was taken to the operating room and underwent an emergency open left radical nephrectomy via a left flank incision. Her recovery was uneventful and she was discharged home after 6 days. The histopathology confirmed a well-differentiated liposarcoma.

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“…Retroperitoneal liposarcomas are arguably much more challenging to treat from a surgical standpoint than are extremity liposarcomas 23, 24 . Tumors in the retroperitoneum are frequently massive in size (median 30 cm) and can involve adjacent visceral organs and critical structures.…”

Section: Surgical Management Of Liposarcomamentioning

confidence: 99%

Recent advances in the management of liposarcoma

Nassif

Tseng

Borges³

et al. 2016

F1000Res

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Liposarcoma is the most common soft tissue sarcoma. With its various subtypes, the natural history of this disease can vary significantly from a locally recurrent tumor to a highly malignant one carrying a poor prognosis. Progress in the understanding of the specific molecular abnormalities in liposarcoma provides greater opportunity for new treatment modalities. Although surgical resection and radiation therapy remain the keystones for the management of primary liposarcoma, the inclusion of novel agents that target known abnormalities in advanced liposarcoma enhances the potential for improved outcomes.

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Contemporary Management of Retroperitoneal Soft Tissue Sarcomas

Cited by 30 publications

References 85 publications

Resection of retroperitoneal sarcoma en‐bloc with inferior vena cava: 20 year outcomes of a single institution

Resection of retroperitoneal sarcoma en‐bloc with inferior vena cava: 20 year outcomes of a single institution

Acute haemorrhage from a retroperitoneal liposarcoma: a rare presentation

Recent advances in the management of liposarcoma

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