Human papillomavirus (HPV) infections are sexually transmitted and contribute significantly to the spread of cancers in both men and women, including oropharyngeal and cervical cancers. The shortcomings of the current preventative strategies are becoming increasingly obvious, underscoring the need for new approaches, especially in the area of health education. Information accessibility, cultural appropriateness, proper management of information accuracy, and the spread of misinformation are emerging as critical focal points for improving the situation. This health policy research review evaluates contributing factors, such as HPV policies, health literacy levels, cultural barriers, healthcare provider-to-patient education, school health education programs, and current awareness campaigns. Based on these findings, the study highlights the most effective strategy for providing actionable information to improve public health: a community-based, multifaceted, but integrated approach to HPV education. To achieve this goal, healthcare provider recommendations are absolutely critical in influencing vaccine decisions. Furthermore, physical and online information materials must be designed at the appropriate reading level, with cultural considerations in mind, and screened to aid comprehension and prevent the spread of misconceptions, stigmas, and misinformation.