Contemporary radiation doses to murine rodents inhabiting the most contaminated part of the EURT

Malinovsky, Georgy; Yarmoshenko, Ilia V.; Zhukovsky, Michael; Starichenko, V.I.; Chibiryak, M. V.

doi:10.1016/j.jenvrad.2013.11.008

Cited by 11 publications

(3 citation statements)

References 24 publications

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“…A total of 1042 animals were used for the study. Of the animals studied, 12 were trapped at the area with initial 90 [29]. In the present study the data on 90 Sr activity was measured using two methods with the assumption that average 90 Sr activity in skeleton is equal to that in long bones and is 1.8 times higher than in skull.…”

Section: Methodsmentioning

confidence: 99%

“…To estimate the internal dose to organs and tissues, the coefficients linking the skeleton 90 Sr activity and absorbed doses were used [29]. These coefficients were calculated using published values of absorbed fractions of beta-radiation energy for different combinations of source and target organs [23] and spectra of 90 Sr and 90 Y radiation [30].…”

Section: Methodsmentioning

confidence: 99%

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Assessment of radiation exposure of murine rodents at the EURT territories

et al. 2014

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The study provides data on contemporary levels of radiation exposure of organs and tissues of murine rodents (several species of mice and voles) inhabiting the East-Ural Radioactive Trace. The estimation procedure involves the most advanced approach based on application of appropriate voxel phantom and biokinetic model. Input data for dose assessment are the results of measurements of skeletal 90Sr activity concentration. Maximal internal dose to skeleton, accumulated during 45 days, is 303 mGy. Median internal dose rates on the last day before trapping were 0.83, 0.092 and 0.023 mGy/day for animals trapped at the sites with initial (1957) 90Sr surface contamination >37 MBq/m2, 18.5–37 MBq/m2 and 0.074–18.5 MBq/m2 respectively. Taking to account internal and external exposures, upper boundary of the ICRP Derived Consideration Reference Level (DCRL) is exceeded on the territory with maximal level of the initial 90Sr surface contamination. On the territory with 18.5–37 MBq/m2, whole body mean dose rates to murine rodents exceed the lower boundary of DCRL. On the areas with lower level of surface contamination, even the 90-th percentile of dose rate is below the DCRL.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Assessment of radiation exposure of murine rodents at the EURT territories

et al. 2014

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“…And on the contrary, the use of the approach of homogenous spongiosa (RODES VI) for dose prediction provides the values comparable with the screening value in the most contaminated area (3.7-37 MBq m -2 ): mean dose rate is ~240 μGy day -1 (up to 400 μGy day -1 ). The homogenous spongiosa approach has been used for murine-specific internal dosimetry in a number of EURT studies (Malinovsky et al 2014;Modorov 2014) using dose factors estimated by Chesser et al (2000) and calculations based on Stabin et all (2006) which are quite similar to the RODES VI value. No changes in murine population size, reproductive activity and morpho-physiological characteristics which may affect the population as a structural unit of the local community and ecosystem were found in the studies (Tarasov 2000;Lyubashevsky et al 2002 a, b;Olenev and Pasechnik 2003;Orekhova and Modorov 2017).…”

Section: Dosimetry Of Rodents Exposed At the East Urals Radioactive T...mentioning

confidence: 99%

Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

Shishkina

Shuiskaya

Sharagin

2022

Radiat Environ Biophys

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Studies of radiobiological effects in murine rodents exposed to internal radiation in the wild or in laboratory experiments require a dosimetric support. The main problem of bone marrow (BM) dosimetry for boneseeking β-emitters is dosimetric modeling due to the fact that the bone is a heterogeneous structure with complex microarchitecture. To date, there are several approaches to calculating the absorbed dose in BM, which mostly use rough geometric approximations. Recently, in the framework of studies of people exposed to 90 Sr in the Urals, a new approach (SPSD) has been developed. The aim of current study was to pilot test the possibility of extension of the SPSD-approach elaborated for humans to mice. The computational phantoms of femur bones of laboratory animals (C57BL/6, C57BL/6J, BALB/c, BALB/cJ) aged 5-8 weeks (growing) and >8 weeks (adults) were created. The dose factors to convert the 89,90 Sr activity concentrations in a bone tissue into units of the dose rate absorbed in the bone marrow were estimated as follows: DFSr-90(BMTBV+CBV) is equal to 1.75±0.42 and 2.57±0.93 (μGy day -1 ) per (Bq g -1 ) for growing and adults, respectively; DFSr-89(BMTBV+CBV) is equal to 1.08±0.27 and 1.66±0.67 (μGy day -1 ) per (Bq g -1 ) for growing and adults, respectively. These results are about 2.5 times lower than skeleton-average DF, calculated assuming the homogenous bone, where source and target coincide. The study demonstrates the possibility of application of the SPSD-approach elaborated for humans to non-human mammals.

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Hematological indicators in pygmy wood mouse Apodemus uralensis (Muridae, Rodentia) populations as markers of the environmental radiation exposure: East Urals radioactive trace (Russia)

Orekhova

2018

Environ Sci Pollut Res

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The hematological effects of chronic radiation exposure in males of the pygmy wood mouse (Apodemus uralensis Pall., 1811) from the East Urals radioactive trace (EURT) area were assessed, taking into account population abundance and reproductive status (immature, ripening, and mature yearlings). For this purpose, we analyzed the morpho-functional characteristics of erythrocytes (red cell indices [MCV, MCH, MCHC], red cell count, activity of antioxidant enzymes [GSH-Px, CAT], lipid peroxidation, glycolysis, osmotic resistance, methaemoglobin content) and blood plasma components (free hemoglobin, total lipids, total cholesterol, and glucose) in the background territory and the EURT area; these areas have a density of soil contamination with Sr of 12,851 and 198 kBq × m, respectively (four and two order of magnitude higher than the background value). The data indicate the "hyperfunctional" state of the erythrocyte, aimed at activation of the gas transport function of blood in the radioactive environment. This, as a consequence, determines the insufficiency of energy supply of the cell defense system necessary to maintain the structural integrity of the membrane. Intensification of membrane lipid peroxidation, reduction of osmotic resistance and GSH-Px activity in red cells, an increase in the degree of intravascular hemolysis, and tendency towards erythropenia indicate the processes of accelerated aging of erythrocytes and their more pronounced destruction in the circulatory bed. The level of the hematological response increased with increasing radiation burden and was more pronounced with a large population size. The interaction effect of "overpopulation" and "radioactive pollution" was observed to a lesser degree for ripening males, and was very small for sexually mature animals. Immature males from the EURT head part with internal whole-body radiation doses of 0.0045-0.35 mGy/day can be considered as the most sensitive group to the factors synergy, including radiation damage and overabundance population.

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Contemporary radiation doses to murine rodents inhabiting the most contaminated part of the EURT

Cited by 11 publications

References 24 publications

Assessment of radiation exposure of murine rodents at the EURT territories

Assessment of radiation exposure of murine rodents at the EURT territories

Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

Hematological indicators in pygmy wood mouse Apodemus uralensis (Muridae, Rodentia) populations as markers of the environmental radiation exposure: East Urals radioactive trace (Russia)

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