Contemporary radiotherapy: present and future

Chandra, Ravi A.; Keane, Florence K.; Voncken, Francine E.M.; Thomas, Charles R.

doi:10.1016/s0140-6736(21)00233-6

Cited by 172 publications

(107 citation statements)

References 127 publications

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“…These therapy modalities are characterized by steep dose falloff with a minimal exit dose beyond a specified target. This allows for a more accurate and precise treatment, reducing healthy tissue exposure and, therefore, the toxicity [132]. Nevertheless, it is important to have in mind that such techniques have a high cost.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

“…In addition, the combination of nanocarrier drug delivery and RT has only been evaluated with single RT courses. Fractionated and hypofractionated RT should be evaluated in future in vivo studies [132].…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

“…Response prediction by means of liquid biopsy and circulating biomarkers allows for a refined treatment with patient stratification by biological parameters. Molecularly designed systems to target specific cancer will lead to future personalized cancer care [132,135].…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

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Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy

Gomes

Franco²

2022

Pharmaceutics

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Cancer is responsible for a significant proportion of death all over the world. Therefore, strategies to improve its treatment are highly desired. The use of nanocarriers to deliver anticancer treatments has been extensively investigated and improved since the approval of the first liposomal formulation for cancer treatment in 1995. Radiotherapy (RT) is present in the disease management strategy of around 50% of cancer patients. In the present review, we bring the state-of-the-art information on the combination of nanocarrier-assisted delivery of molecules and RT. We start with formulations designed to encapsulate single or multiple molecules that, once delivered to the tumor site, act directly on the cells to improve the effects of RT. Then, we describe formulations designed to modulate the tumor microenvironment by delivering oxygen or to boost the abscopal effect. Finally, we present how RT can be employed to trigger molecule delivery from nanocarriers or to modulate the EPR effect.

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Section: Limitations and Future Directionsmentioning

confidence: 99%

Section: Limitations and Future Directionsmentioning

confidence: 99%

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Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy

Gomes

Franco²

2022

Pharmaceutics

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“…Radiation therapy is a highly targeted treatment accurately suppressing the tumor with wide ranging application, and contributed to approximately 40% of all cancer cures across the world ( 1 ). This treatment modality is also very effective for other cancer related problems including pain, tumor bleeding, and acute superior vena cava syndrome ( 2 – 4 ).…”

Section: Introductionmentioning

confidence: 99%

Application of Proteomics in the Discovery of Radiosensitive Cancer Biomarkers

Luo

2022

Front. Oncol.

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Radiation therapy remains an important component of cancer treatment. Gene-encoded proteins were the actual executors of cellular functions. Proteomic was a novel technology that can systematically analysis protein composition and measure their levels of change, this was a high throughput method, and were the import tools in the post genomic era. In recent years, rapid progress of proteomic have been made in the study of cancer mechanism, diagnosis, and treatment. This article elaborates current advances and future directions of proteomics in the discovery of radiosensitive cancer biomarkers.

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“… [1] Every second patient diagnosed with cancer will receive radiotherapy (RT) during their treatment history. [2] Recent studies have shown that improved overall survival of many cancer patients is associated with an increasing number of patients treated with multiple repeat RT (MRRT), in curative or palliative intent. [3] This ongoing transformation of cancer into a chronic disease requires an increased consideration of quality-of-life (QoL), long-term and cumulative toxicity of multiple anti-center interventions, patient-reported experiences and satisfaction (PRES), and psychological distress to provide optimal cancer care.…”

Section: Introductionmentioning

confidence: 99%