There has been little change in the mortality from infective endocarditis, despite the diagnostic and therapeutic advances made in the last 25 years. The current in-hospital mortality rate for patients with IE is 15% -20%, with 1-year mortality approaching 40%. The morbidity associated with infective endocarditis includes: valvular incompetence, embolisation, cerebrovascular accidents and congestive heart failure which have influenced the surgical approaches to a great extent. Infective endocarditis is a significant problem in sub-Saharan Africa and is related to a high prevalence of rheumatic heart disease among the young indigent population. Africa has the highest burden of rheumatic heart disease contributing 17% -43% of all heart disease.