Contemporary Role of Cardiac Magnetic Resonance in the Management of Patients with Suspected or Known Coronary Artery Disease

Bazoukis, George; Papadatos, Stamatis S; Michelongona, Archontoula; Λαμπρόπουλος, Κωνσταντίνος; Farmakis, Dimitrios; Vassiliou, Vassilios

doi:10.3390/medicina57070649

Cited by 4 publications

(3 citation statements)

References 68 publications

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“…CMR, and especially stress CMR, has a significant role for the detection of acute and chronic ischemia, 79 providing an assessment of myocardial viability by LGE imaging, functional perfusion abnormalities using stress first-pass perfusion imaging, alongside the gold standard measurement of ventricular function. 80,81 Importantly, thanks to its unique ability for tissue characterization, it is able to investigate and diagnose coronary mimics, such as myocarditis or takotsubo cardiomyopathy-both relatively common causes of acute cardiotoxic events.…”

Section: Cardiovascular Magnetic Resonancementioning

confidence: 99%

Multimodality Imaging for Cardiotoxicity: State of the Art and Future Perspectives

Artico

Abiodun

Shiwani

et al. 2022

Journal of Cardiovascular Pharmacology

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Modern cancer therapies have significantly improved survival leading to a growing population of cancer survivors. Similarly, both conventional and newer treatments are associated with a spectrum of cardiovascular disorders with potential long-term sequelae. Prompt detection and treatment of these complications is, therefore, pivotal to enable healthy survivorship and reduce cardiovascular morbidity. Advanced multimodality imaging is a valuable tool for stratifying patient risk, identifying cardiovascular toxicity during and after therapy, and predicting recovery. This review summarizes the potential cardiotoxic complications of anticancer therapies and the multimodality approaches available in each case with special focus on newer techniques and the added value of biomarkers ultimately leading to earlier diagnosis and better prognostication.

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Section: Cardiovascular Magnetic Resonancementioning

confidence: 99%

Multimodality Imaging for Cardiotoxicity: State of the Art and Future Perspectives

Artico

Abiodun

Shiwani

et al. 2022

Journal of Cardiovascular Pharmacology

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“…β‐Thalassemia major as a TDT and β‐thalassemia intermedia as a NTDT can cause iron overload due to regular transfusion and increased intestinal absorption, respectively 17 . Both groups of patients may suffer from cardiac complications due to iron overload 18,19 . Therefore, a close cardiovascular surveillance is reasonable, particularly in β‐thalassemia patients with increased baseline risk.…”

Section: Introductionmentioning

confidence: 99%

“… 17 Both groups of patients may suffer from cardiac complications due to iron overload. 18 , 19 Therefore, a close cardiovascular surveillance is reasonable, particularly in β‐thalassemia patients with increased baseline risk. This baseline risk can be previous cardiovascular comorbidities such as myocardial T2* <20 ms (ms), a personal history of previous or current impaired left ventricular function or a serum ferritin level >2000 ng/mL.…”

Section: Introductionmentioning

confidence: 99%

Role of feature tracking cardiac magnetic resonance imaging in early detection of cardiac dysfunction in β‐thalassemia patients recovered from COVID‐19: A cross‐sectional study

Houshmand,

Parsaee,

Najmafshar

et al. 2024

Health Science Reports

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Background and Aimsβ‐Thalassemia patients may have cardiac complications due to iron overload, which puts them at higher risk of cardiac complications induced by coronavirus disease 2019 (COVID‐19) compared with the normal population. The present study aims to evaluate early cardiovascular complications following iron overload in β‐thalassemia patients who had early recovery from COVID‐19 by cardiac magnetic resonance imaging (MRI) and feature‐tracking technique.MethodsThirty‐two confirmed COVID‐19‐recovered β‐thalassemia cases were evaluated within 3 weeks to 3 months after a positive reverse‐transcriptase polymerase chain reaction COVID‐19 test. Both the heart and liver of all patients were examined using cardiac MRI.ResultsWe analyzed 32 patients with mean age of 32.84 ± 6.45 years at baseline. Left ventricular global strain values were significantly associated with myocardial T2*. A cut‐off value of −15.08% for global longitudinal strain (GLS) with sensitivity and specificity of 90% and 61.1% (p = 0.017), 32.33% for global radial strain (GRS) with sensitivity and specificity of 80% and 94.4% (p = 0.001) and −16.21 for global circumferential strain (GCS), with sensitivity and specificity of 80% and 89.9% (p = 0.013) may indicate cardiac iron overload.ConclusionGLS, GRS, and GCS were significantly decreased in patients with myocardial T2* <20 ms (iron overload), while no significant change was observed in the right and left ventricular ejection fraction (RV‐ and LVEF). Cardiac MRI feature‐tracking may be helpful in the early detection of cardiac complications resulting from iron overload in β‐thalassemia patients who had early recovery from COVID‐19.

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Epicardial Adipocytes in Cardiac Pathology and Healing

La,

Nair,

Sunny

et al. 2024

Cardiovasc Drugs Ther

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Implications of epicardial adipose tissue (EAT) on the development of coronary artery disease (CAD) have garnered recent attention. Located between the myocardium and visceral pericardium, EAT possesses unique morphological and physiological contiguity to the heart. The transcriptome and secretome of EAT differ from that of other fat stores in the body. Physiologically, EAT protects the adjacent myocardium through its brown-fat-like thermogenic function and rapid fatty acid oxidation. However, EAT releases pro-inflammatory mediators acting on the myocardium and coronary vessels, thus contributing to the development and progression of cardiovascular diseases (CVD). Furthermore, EAT-derived mesenchymal stromal cells indicate promising regenerative capabilities that offer novel opportunities in cell-based cardiac regeneration. This review aims to provide a comprehensive understanding and unraveling of EAT mechanisms implicated in regulating cardiac function and regeneration under pathological conditions. A holistic understanding of the multifaceted nature of EAT is essential to the future development of pharmacological and therapeutic interventions for the management of CVD.

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Contemporary Role of Cardiac Magnetic Resonance in the Management of Patients with Suspected or Known Coronary Artery Disease

Cited by 4 publications

References 68 publications

Multimodality Imaging for Cardiotoxicity: State of the Art and Future Perspectives

Multimodality Imaging for Cardiotoxicity: State of the Art and Future Perspectives

Role of feature tracking cardiac magnetic resonance imaging in early detection of cardiac dysfunction in β‐thalassemia patients recovered from COVID‐19: A cross‐sectional study

Epicardial Adipocytes in Cardiac Pathology and Healing

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