Contemporary standpoint and future of 3D bioprinting in tissue/organs printing

Reddy, Vundrala Sumedha; Brindha, R.; Telrandhe, Vedant Mohan; Ramakrishna, Seeram

doi:10.1016/j.cobme.2023.100461

Cited by 11 publications

(7 citation statements)

References 45 publications

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“…The hydrogel design can be composed of either naturally occurring or artificially made biomaterials [3]. The efficacy of natural biomaterials stems from their bioactivity.…”

Section: Bioprinting Materials Requirementsmentioning

confidence: 99%

“…Nonetheless, they do exhibit mechanical fragility in comparison to their synthetic counterparts, which inhibits the stability of the printed construct. Thus, choosing which bioink to use is predicated on many factors [3]. An optimal bioink should possess specific physicochemical attributes, encompassing suitable mechanical, rheological, chemical, and biological properties.…”

Section: Bioprinting Materials Requirementsmentioning

confidence: 99%

“…Many elements have gone through experimentation; the most common of these elements come from non-human species, such as gelatin from pig flesh and alginate from seaweed. These components' alien origins increase the risk of infection, inflammation, and immunogenicity [3]. Based on the role they play, bioinks can be classified into four categories.…”

Section: Challenges Facedmentioning

confidence: 99%

“…Processes including cell motility, post-printing phenotype, carcinogenic potential, and dysregulated differentiation will be impacted by variations in a patient's genotype. In the end, since bioprinting is a vaguely new concept, much research needs to be done before it can be a common implant procedure [3].…”

Section: Challenges Facedmentioning

confidence: 99%

“…Tragically, despite being on the waitlist, approximately 20 individuals lost their lives each day. It has been reported that the number of people waiting for organ transplants has increased by 7% over the last ten years, but that the number of donors and transplants has remained relatively the same [3].…”

Section: Introductionmentioning

confidence: 99%

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Three-Dimensional Bioprinting in Medicine: A Comprehensive Overview of Current Progress and Challenges Faced

Veeravalli,

Vejandla,

Savani

et al. 2023

Cureus

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The shortage of organs for transplantation is a global crisis, with an increasing demand and an inadequate supply of organ donors. The convergence of biology and engineering has led to the emergence of 3D bioprinting, which enables the precise and customizable construction of biological structures. Various 3D bioprinting techniques include inkjet printing, extrusion printing, and laser-assisted bioprinting (LAB).Although it has the potential for many benefits, 3D bioprinting comes with its own set of challenges and requirements, specifically associated with the bioprinting of various tissues. The challenges of bioprinting include issues with cells, bioinks, and bioprinters, as well as ethical concerns, clinical efficacy, and costeffectiveness, making it difficult to integrate 3D bioprinting into widespread clinical practice. Threedimensional bioprinting holds great promise in addressing the organ shortage crisis, and its applications extend beyond organ transplantation to include drug screening, disease modeling, and regenerative medicine. However, further research is needed to overcome the technical, biological, and ethical challenges associated with 3D bioprinting, paving the way for its widespread clinical implementation. This article discusses the processes and challenges of bioprinting as well as the current research direction in the field.

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“…The hydrogel design can be composed of either naturally occurring or artificially made biomaterials [3]. The efficacy of natural biomaterials stems from their bioactivity.…”

Section: Bioprinting Materials Requirementsmentioning

confidence: 99%

Section: Bioprinting Materials Requirementsmentioning

confidence: 99%

Section: Challenges Facedmentioning

confidence: 99%

Section: Challenges Facedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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