Contemporary status of genetic rationale for arrhythmias

Bockeriа, L.A.; Pronicheva, I.V.

doi:10.15275/annaritmol.2018.3.2

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…LQTS is characterized by a particular electrocardiographic pattern immediately prior to the ventricular tachycardia, the so-called short-long-short sequence (SLS) or "cascade" phenomenon, which includes alternation of shortening of RR intervals due to supraventricular premature contraction (short), followed by post-premature contraction pause (long) and repeated ventricular premature contraction (short), with subsequent "torsades de pointes" tachycardia ( Fig. 3) [12,18]. In 2011, P. Schwartz presented updated diagnostic criteria for LQTS ( Table 1).…”

Section: Congenital Long Qt Syndrome (Lqts)mentioning

confidence: 99%

Monogenec Arrhythmic Syndromes: From Molecular and Genetic Aspects to Bedside

et al. 2016

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The abrupt cessation of effective cardiac function that is generally due to heart rhythm disorders can cause sudden and unexpected death at any age and is referred to as a syndrome called sudden cardiac death (SCD). Annually, about 400,000 cases of SCD occur in the United States alone. Less than 5% of the resuscitation techniques are effective. The prevalence of SCD in a population rises with age according to the prevalence of coronary artery disease, which is the most common cause of sudden cardiac arrest. However, there is a peak in SCD incidence for the age below 5 years, which is equal to 17 cases per 100,000 of the population. This peak is due to congenital monogenic arrhythmic canalopathies. Despite their relative rarity, these cases are obviously the most tragic. The immediate causes, or mechanisms, of SCD are comprehensive. Generally, it is arrhythmic death due to ventricular tachyarrythmias - sustained ventricular tachycardia (VT) or ventricular fibrillation (VF). Bradyarrhythmias and pulseless electrical activity account for no more than 40% of all registered cardiac arrests, and they are more often the outcome of the abovementioned arrhythmias. Our current understanding of the mechanisms responsible for SCD has emerged from decades of basic science investigation into the normal electrophysiology of the heart, the molecular physiology of cardiac ion channels, the fundamental cellular and tissue events associated with cardiac arrhythmias, and the molecular genetics of monogenic disorders of the heart rhythm (for example, the long QT syndrome). This review presents an overview of the molecular and genetic basis of SCD in the long QT syndrome, Brugada syndrome, short QT syndrome, catecholaminergic polymorphic ventricular tachycardia and idiopathic ventricular fibrillation, and arrhythmogenic right ventricular dysplasia, and sudden cardiac death prevention strategies by modern techniques (including implantable cardioverter-defibrillator).

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Section: Congenital Long Qt Syndrome (Lqts)mentioning

confidence: 99%

Monogenec Arrhythmic Syndromes: From Molecular and Genetic Aspects to Bedside

et al. 2016

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Role of genetic research in the prevention of life-threatening rhythm and cardiac conduction disorders in young people

et al. 2022

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According to epidemiological studies, in Russia there is a tendency towards an increase in sudden cardiac death (SCD), including among young workingage people. The leading mechanism for SCD in young patients, including those with undifferentiated connective tissue disease, is recognized as rhythm and conduction disorders. At the same time, the most tragic cases are the first and only manifestation of SCD in children and young people without structural heart disease. The article presents a brief analysis of the genetic causes of life-threatening rhythm and conduction disorders in young people, as well as a generalization of the modern possibilities of a personalized diagnostic approach from the standpoint of early cardiovascular prevention. Timely genetic diagnosis of SCD risk makes it possible to identify a predisposition to the development of a fatal event long before its occurrence, which contributes to the timely implementation of preventive measures within a high cardiovascular risk strategy and secondary prevention, maintaining working capacity, creative and social activity of young patients, and improving the quality of life.

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Somatometric characteristics of patients with Wolff-Parkinson-White syndrome

Tolstokorova,

Nikulina,

Chernova

2024

Russ J Cardiol

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Aim. To study the distribution of somatometric indicators and indices of patients with Wolff-Parkinson-White (WPW) syndrome.Material and methods. All patients underwent following clinical and paraclinical investigations: electrocardiography (ECG), Holter ECG monitoring, echocardiography. In addition, we performed somatometric study according to the standard method of V.V. Bunak. The main group consisted of 200 patients with WPW syndrome (men, n=97 (32,6±9,4 years); women, n=103 (47,92±11,6 years)).Results. Anthropometry performed according to James Tanner revealed that in the general group of WPW syndrome individuals, mesomorphs prevailed (57%). A similar pattern was observed both in the groups of women (25,5%) and men (31,5%). According to the Rees-Eysenck index, the general group of WPW syndrome individuals, normosthenics (37%) and pyknics (38%) prevailed. However, in the group of women, normosthenics prevailed (24%), and in the group of men, pyknics (23,5%). The relationship analysis using Pearson's chi-squared test revealed the following: in the group of women, the WPW syndrome was moderately correlated with the thigh fat fold (0,52), and in the group of men — with the abdominal fat fold (0,56).Conclusion. Somatometric study, taking into account the indices (J. Tanner, Rees-Eysenck), confirms the relationship between the risk of cardiovascular diseases and overweight. This can be useful for taking preventive measures in relation to groups of people with certain anthropometric features, when assessing the risk of arrhythmias within the concept of personalized medicine.

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Contemporary status of genetic rationale for arrhythmias

Cited by 3 publications

References 47 publications

Monogenec Arrhythmic Syndromes: From Molecular and Genetic Aspects to Bedside

Monogenec Arrhythmic Syndromes: From Molecular and Genetic Aspects to Bedside

Role of genetic research in the prevention of life-threatening rhythm and cardiac conduction disorders in young people

Somatometric characteristics of patients with Wolff-Parkinson-White syndrome

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