Contemporary therapeutic management of locally advanced hypopharyngeal cancer: oncologic and functional outcomes – a report on 100 cases

Abstract

A total of 100 patients were included in this study. Induction chemotherapy (CT) followed by radiotherapy (RT) ± CT, primary RT + CT, and primary total pharyngolaryngectomy (TPL) comprised the initial therapeutic management for 54, 24, and 20 patients, respectively. Two patients received only supportive care. Overall survival (OS) and cause-specific survival (SS) were 50% and 60% at 3 years, respectively. In the group of patients referred for induction CT, the 3-year OS and SS were 58% and 70%, respectively. In multivariate analysis, T stage (p = 0.05) and ASA score (p = 0.02) were significant predictive factors of OS. T4 tumor stage had a pejorative impact on swallowing function after therapy (p = 0.006). The rate of patients alive, disease-free, and with a functional larynx at 2 years was 23%.

Management of advanced hypopharyngeal carcinoma: systematic review of survival following surgical and non-surgical treatments

“…The systematic review included 2 randomised controlled trials 11 , 33 and 11 observational studies 9 , 26 , 27 , 34 – 41 . A thorough search of PubMed and Medline, Embase, Scopus, the Cochrane Library, and Google Scholar yielded 5639 citations.…”

“…All 11 non-randomised studies were retrospective observational studies that were published in English 9 , 26 , 27 , 34 – 41 . All studies with the exception of two reported data only on advanced stage hypopharyngeal cancer.…”

“…There were 1273 males and 47 females. All participants (Table IV 9 , 26 , 27 , 34 – 43 ) met the inclusion criteria, which required adults with resectable advanced stage hypopharyngeal carcinoma, who received either surgical or non-surgical treatment.…”

“…Data were entered into Microsoft ™ Excel software (2013) to generate tables and graphs. Two authors were contacted via e-mail for missing data for two of the studies selected for inclusion in the review 26 , 27 . Unfortunately, the missing data were not provided before this study was completed.…”

The diagnostic role of diffusion-weighted magnetic resonance imaging in hypopharyngeal carcinoma

“…Hypopharyngeal carcinoma has one of the poorest prognoses of all head and neck carcinomas as it is frequently diagnosed at an advanced stage and exhibits aggressive and distant metastasis ( 1 ). Although there have been significant advancements in surgical techniques and chemoradiotherapy recently, the prognosis of hypopharyngeal carcinoma remains unsatisfactory ( 2 ).…”