Contemporary Understandings of Cardiovascular Disease After Cancer Radiotherapy: a Focus on Ischemic Heart Disease

Kim, Lisa; Loccoh, Eméfah; Sanchez, Reynaldo; Ruz, Patrick; Anaba, Uzoma; Williams, Terence M.; Slivnick, Jeremy; Vallakati, Ajay; Baliga, Ragavendra R.; Ayan, A.S.; Miller, Eric D.

doi:10.1007/s11886-020-01380-4

Cited by 8 publications

(3 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acute pericarditis may have been reduced in recent years due to advancements in radiation therapy techniques, but chronic pericardial effusions and pericardiac constriction have increased. The chronic pericardial inflammatory process can cause thickening, increased rigidity, calcification of the pericardial sac, and loss of pericardial compliance [ 22 ]. Pericardial thickening, neutrophil infiltrations, and calcifications can cause constriction pathophysiology [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review

Siaravas

Katsouras

Sioka

2023

IJMS

View full text Add to dashboard Cite

Radiotherapy may be used alone or in combination with chemotherapy for cancer treatment. There are many mechanisms of radiation treatment exposure to toxicities. Our aim was to summarize the literature about known mechanisms of radiation-induced cardiac toxicities. We performed a systematic review of the literature on the PubMed database until October 2022 about cardiovascular toxicities and radiation therapy exposure. Only systematic reviews, meta-analyses, and reviews were selected. Out of 1429 publications screened, 43 papers met inclusion criteria and were selected for the umbrella review process. Microvascular and macrovascular complications could lead to adverse cardiac effects. Many radiotherapy-associated risk factors were responsible, such as the site of radiation treatment, beam proximity to heart tissues, total dosage, the number of radiotherapy sessions, adjuvant chemotherapeutic agents used, and patient traditional cardiovascular risk factors, patient age, and gender. Moreover, important dosage cutoff values could increase the incidence of cardiac toxicities. Finally, the time from radiation exposure to cardiac side effects was assessed. Our report highlighted mechanisms, radiation dosage values, and the timeline of cardiovascular toxicities after radiation therapy. All of the above may be used for the assessment of cardiovascular risk factors and the development of screening programs for cancer patients.

show abstract

Section: Resultsmentioning

confidence: 99%

Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review

Siaravas

Katsouras

Sioka

2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Several studies have demonstrated that cancer survivors have a higher incidence and risk of IHD than the general population [8][9][10]. Although IHD and cancer have distinct pathophysiological mechanisms and affect different organ systems, these often occur in the same patient owing to the common biological pathways and risk factors such as obesity, diabetes, and smoking [11,12], as well as inflammatory and hypercoagulable conditions often associated with many cancer types [13,14].…”

Section: Introductionmentioning

confidence: 99%

Association between Head and Neck Cancer and Increased Risk of Ischemic Heart Disease: A Retrospective Cohort Study Using National Population Data

Kim,

Yu,

Kim

2024

Cancers

View full text Add to dashboard Cite

Although cancer and ischemic heart disease (IHD) frequently manifest in the same individual, the risk of IHD events in cancer, especially head and neck cancer (HNC), remains unclear. We aimed to examine the incidence and risk of IHD events in patients with HNC using a population-based cohort dataset in South Korea (2002–2013). Through rigorous propensity score matching, we compared data from 2816 individuals without HNC and 704 individuals with HNC. Key independent variables were matched between groups, and the Charlson Comorbidity Index was used to match comorbidities. The Kaplan–Meier method depicted the cumulative probability of IHD throughout the follow-up period for both the study and control groups. The overall IHD incidence was significantly higher (19.93) in patients with HNC than in those without HNC (14.81), signifying an augmented IHD risk in the HNC cohort. Subsequent temporal analysis revealed a significant surge in IHD risk commencing 4 years after HNC diagnosis and persisting throughout the follow-up period. Subgroup analysis revealed an increased IHD risk in men with HNC and patients with cancers affecting the oral and sinonasal regions. This retrospective cohort study provides valuable scientific insights into the nuanced relationship between HNC and IHD, underscoring the need for tailored monitoring protocols and specialized care for susceptible individuals.

show abstract

“…The serious adverse effects also limit the efficacy of radiotherapy. 3 With a deep understanding of the biomolecular behavior of tumor cells, tumor-targeted drugs with fewer side effects have been widely used in cancer chemotherapy. [4][5][6] Various nanocarriers have been used for smart drug delivery systems, and the properties of the nanocarriers can impart imaging performance to the system, enabling the construction of theranostic nanoplatforms.…”

Section: Introductionmentioning

confidence: 99%