Content-specific activity in frontoparietal and default-mode networks during prior-guided visual perception

González-García, Carlos; Flounders, Matthew W.; Chang, Raymond Chuen‐Chung; Baria, Alexis T.; He, Biyu J.

doi:10.7554/elife.36068

Cited by 56 publications

(83 citation statements)

References 63 publications

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“…Similarly, regions of the pCC have also been ascribed an important role in a process that is often described as scene construction [48]. In the context of these observations, the current data provide additional evidence supporting a role for the DMN in broader features of cognition, such as how it is being represented, rather than more local features such as what it is about [19, 49]. The pCC may be particularly important for this process because studies have shown that this region of cortex contains echoes of multiple different regions, including those outside of the DMN [50, 51, 52].…”

Section: Discussionsupporting

confidence: 58%

Hello, is that me you are looking for? A re-examination of the role of the DMN in social and self relevant aspects of off-task thought

Murphy¹,

Poerio²,

Sormaz³

et al. 2019

PLoS ONE

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Neural activity within the default mode network (DMN) is widely assumed to relate to processing during off-task states, however it remains unclear whether this association emerges from a shared role in self or social content that is common in these conditions. In the current study, we examine the possibility that the role of the DMN in ongoing thought emerges from contributions to specific features of off-task experience such as self-relevant or social content. A group of participants described their experiences while performing a laboratory task over a period of days. In a different session, neural activity was measured while participants performed Self/Other judgements (e.g., Does the word ‘Honest’ apply to you (Self condition) or Barack Obama (Other condition)). Despite the prominence of social and personal content in off-task reports, there was no association with neural activity during off-task trait adjective judgements. Instead, during both Self and Other judgements we found recruitment of caudal posterior cingulate cortex—a core DMN hub—was above baseline for individuals whose laboratory experiences were characterised as detailed. These data provide little support for a role of the DMN in self or other content in the off-task state and instead suggest a role in how on-going thought is represented.

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Section: Discussionsupporting

confidence: 58%

Hello, is that me you are looking for? A re-examination of the role of the DMN in social and self relevant aspects of off-task thought

Murphy¹,

Poerio²,

Sormaz³

et al. 2019

PLoS ONE

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“…Various neuroimaging techniques have been used in these experiments: positron-emission tomography (PET) ( Dolan et al., 1997 ), functional magnetic resonance imaging (fMRI) ( Hegdé and Kersten, 2010 ; Ludmer et al., 2011 ; Gorlin et al., 2012 ; Van Loon et al., 2016 ; González-García et al., 2018 ), electroencephalography (EEG) ( Jemel et al., 2003 ; Goffaux et al., 2004 ; Martens et al., 2012 ; Minami et al., 2014 ; Samaha et al., 2016 ), MEG ( Urakawa et al., 2015 ; Flounders et al., 2019 ), repetitive transcranial magnetic stimulation (rTMS) ( Giovannelli et al., 2010 ) and even single neuron recording in a monkeys ( Tovee et al., 1996 ). In these studies, recognition effects were found in low-level visual areas ( Gorlin et al., 2012 ; Van Loon et al., 2016 ), ventral occipito-temporal regions ( Tovee et al., 1996 ; Dolan et al., 1997 ; Gorlin et al., 2012 ; Hegdé and Kersten, 2010 ; Martens et al., 2012 ; Urakawa et al., 2015 ; Van Loon et al., 2016 ), parietal cortex ( Dolan et al., 1997 ; Giovannelli et al., 2010 ; Minami et al., 2014 ; González-García et al., 2018 ), and frontal cortex ( Martens et al., 2012 ; González-García et al., 2018 ). Localization information has been drawn largely from fMRI based studies, whilst time-resolved EEG and MEG has provided temporal information about processing of disambiguated images.…”

Section: Discussionmentioning

confidence: 99%

Object recognition is enabled by an experience-dependent appraisal of visual features in the brain’s value system

et al. 2020

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This paper addresses perceptual synthesis by comparing responses evoked by visual stimuli before and after they are recognized, depending on prior exposure. Using magnetoencephalography, we analyzed distributed patterns of neuronal activity – evoked by Mooney figures – before and after they were recognized as meaningful objects. Recognition induced changes were first seen at 100–120 ms, for both faces and tools. These early effects – in right inferior and middle occipital regions – were characterized by an increase in power in the absence of any changes in spatial patterns of activity. Within a later 210–230 ms window, a quite different type of recognition effect appeared. Regions of the brain’s value system (insula, entorhinal cortex and cingulate of the right hemisphere for faces and right orbitofrontal cortex for tools) evinced a reorganization of their neuronal activity without an overall power increase in the region. Finally, we found that during the perception of disambiguated face stimuli, a face-specific response in the right fusiform gyrus emerged at 240–290 ms, with a much greater latency than the well-known N170m component, and, crucially, followed the recognition effect in the value system regions. These results can clarify one of the most intriguing issues of perceptual synthesis, namely, how a limited set of high-level predictions, which is required to reduce the uncertainty when resolving the ill-posed inverse problem of perception, can be available before category-specific processing in visual cortex. We suggest that a subset of local spatial features serves as partial cues for a fast re-activation of object-specific appraisal by the value system. The ensuing top-down feedback from value system to visual cortex, in particular, the fusiform gyrus enables high levels of processing to form category-specific predictions. This descending influence of the value system was more prominent for faces than for tools, the fact that reflects different dependence of these categories on value-related information.

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“…The correlations between the inter-network FC with neuropsychological performances supported our assumption, that the dysconnectivity of DMN might be associated with the cognitive or emotional states in SNHL. DMN also participates in the perceptual processing through retrieving the information memory, which is elucidated by recent functional imaging studies (González-García et al, 2018). Based on these notions, this dissociation pattern of FC with aDMN and pDMN observed in this study indicated the involvement of higher-order cognitive networks in the functional reorganization of SNHL and the modified coordination between DMN with both higher-order control networks (i.e., DAN, FPN) and sensory processing networks (i.e., LVN, MVN, SMN, and pTMN) following hearing deprivation.…”

Section: Discussionmentioning

confidence: 99%

Dysconnectivity of Multiple Resting-State Networks Associated With Higher-Order Functions in Sensorineural Hearing Loss

et al. 2019

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Objects: Sensorineural hearing loss (SNHL) involves wide-ranging functional reorganization, and is associated with accumulating risk of cognitive and emotional dysfunction. The coordination of multiple functional networks supports normal brain functions. Here, we aimed to evaluate the functional connectivity (FC) patterns involving multiple resting-state networks (RSNs), and the correlations between the functional remodeling of RSNs and the potential cognitive or emotional impairments in SNHL.Methods: Thirty long-term bilateral SNHL patients and 39 well-matched healthy controls were recruited for assessment of resting-state functional magnetic resonance imaging and neuropsychological tests.Results: Using independent component analysis, 11 RSNs were identified. Relative to the healthy controls, patients with SNHL presented apparent abnormalities of intra-network FC involving right frontoparietal network, posterior temporal network, and sensory motor network. Disrupted between-network FC was also revealed in the SNHL patients across both higher-order cognitive control networks and multiple sensory networks. Eight of the eleven RSNs showed altered functional synchronization using a seed network to whole brain FC method, particularly in the ventromedial prefrontal cortex. In addition, these functional abnormalities were correlated with cognition- and emotion-related performances.Interpretations: These findings supported our hypotheses that long-term SNHL involves notable dysconnectivity of multiple RSNs. Our study provides important insights into the pathophysiological mechanisms of SNHL, and sheds lights on the neural substrates underlying the possible cognitive and emotional dysfunctions following SNHL.

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Content-specific activity in frontoparietal and default-mode networks during prior-guided visual perception

Cited by 56 publications

References 63 publications

Hello, is that me you are looking for? A re-examination of the role of the DMN in social and self relevant aspects of off-task thought

Hello, is that me you are looking for? A re-examination of the role of the DMN in social and self relevant aspects of off-task thought

Object recognition is enabled by an experience-dependent appraisal of visual features in the brain’s value system

Dysconnectivity of Multiple Resting-State Networks Associated With Higher-Order Functions in Sensorineural Hearing Loss

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