Content variations of triterpenic acid, nucleoside, nucleobase, and sugar in jujube (Ziziphus jujuba) fruit during ripening

Guo, Sheng; Duan, Jin‐Ao; Qian, Dawei; Tang, Yuping; Wu, Dawei; Su, Shulan; Wang, Hanqing; Zhao, Yunan

doi:10.1016/j.foodchem.2014.07.013

Cited by 122 publications

(88 citation statements)

References 30 publications

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“…High amounts of oleanolic acid are also present in edible parts of jujube ( Ziziphus jujube Mill. ), a commonly consumed fruit in Southern Asia and China [30]. …”

Section: Sources and Bioavailabilitymentioning

confidence: 99%

Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy

Žiberna

Šamec

Mocan

et al. 2017

IJMS

116

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Nowadays, much attention has been paid to diet and dietary supplements as a cost-effective therapeutic strategy for prevention and treatment of a myriad of chronic and degenerative diseases. Rapidly accumulating scientific evidence achieved through high-throughput technologies has greatly expanded the understanding about the multifaceted nature of cancer. Increasingly, it is being realized that deregulation of spatio-temporally controlled intracellular signaling cascades plays a contributory role in the onset and progression of cancer. Therefore, targeting regulators of oncogenic signaling cascades is essential to prevent and treat cancer. A plethora of preclinical and epidemiological evidences showed promising role of phytochemicals against several types of cancer. Oleanolic acid, a common pentacyclic triterpenoid, is mainly found in olive oil, as well as several plant species. It is a potent inhibitor of cellular inflammatory process and a well-known inducer of phase 2 xenobiotic biotransformation enzymes. Main molecular mechanisms underlying anticancer effects of oleanolic acid are mediated by caspases, 5 adenosine monophosphate-activated protein kinase, extracellular signal-regulated kinase 1/2, matrix metalloproteinases, pro-apoptotic Bax and bid, phosphatidylinositide 3-kinase/Akt1/mechanistic target of rapamycin, reactive oxygen species/apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase, nuclear factor-κB, cluster of differentiation 1, CKD4, s6k, signal transducer and activator of transcription 3, as well as aforementioned signaling pathways . In this work, we critically review the scientific literature on the molecular targets of oleanolic acid implicated in the prevention and treatment of several types of cancer. We also discuss chemical aspects, natural sources, bioavailability, and safety of this bioactive phytochemical.

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“…High amounts of oleanolic acid are also present in edible parts of jujube ( Ziziphus jujube Mill. ), a commonly consumed fruit in Southern Asia and China [30]. …”

Section: Sources and Bioavailabilitymentioning

confidence: 99%

Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy

Žiberna

Šamec

Mocan

et al. 2017

IJMS

116

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“…Fruit ripening is a highly complex and essential process that determines fruit quality and flavor desirability. Previous studies revealed the following physicochemical variations in jujube fruit in different growth stages: changes in respiration rate, ethylene production, contents of free amino acids, proteins, sugars, organic acids, ascorbic acid, carotenoids, phenolic acids, proanthocyanidins, flavonoids, triterpenic acids, nucleosides and nucleobases, antioxidant capacity, cancer cell inhibition and anti‐glycation activity . The modification of chemical characteristics of pectin is also influenced by the ripening process and thus alters its functional properties.…”

Section: Introductionmentioning

confidence: 99%

Changes in pectin characteristics during the ripening of jujube fruit

et al. 2017

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The content, neutral sugar composition, DM and M distribution of pectins changed markedly as jujube fruit ripened. Jujube fruit could be a promising alternative source of pectins in terms of maturation degree. WSP from S6 and CSP from S1 or S2 could be used as gelling agents in low-sugar-containing products because of their low methoxyl pectin contents. WSP from S1 could also be applied as a thickener or emulsifier owing to its high M distribution. © 2017 Society of Chemical Industry.

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“…is a native fruit of China and widely distributed throughout the warmer parts of Asia, Australia, Russia, northern Africa, southern Europe, the Middle East, and south‐western USA . Its fruits are widely consumed in Asian countries as a food and food additive due to their high nutritional value . Jujube fruit is important in traditional Chinese medicine and is recommended for the treatment of some diseases such as tumours and cardiovascular disease related to the production of radical species resulting from oxidative stress .…”

Section: Introductionmentioning

confidence: 99%

Physico-chemical and physiological changes during fruit development and on-tree ripening of two Spanish jujube cultivars (Ziziphus jujuba Mill.)

Almansa

Hernández

Legua

et al. 2016

J. Sci. Food Agric.

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Content variations of triterpenic acid, nucleoside, nucleobase, and sugar in jujube (Ziziphus jujuba) fruit during ripening

Cited by 122 publications

References 30 publications

Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy

Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy

Changes in pectin characteristics during the ripening of jujube fruit

Physico-chemical and physiological changes during fruit development and on-tree ripening of two Spanish jujube cultivars (Ziziphus jujuba Mill.)

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